2. Others GPCR/G Protein Neuronal Signaling JAK/STAT Signaling Stem Cell/Wnt
  3. Isotope-Labeled Compounds Dopamine Receptor Adrenergic Receptor STAT
  4. Pimozide-d5 N-Oxide

Pimozide-d5 N-Oxide  (Synonyms: 匹莫齐特 d5（N 氧化物）)

目录号: HY-12987S1
产品使用指南

摩尔计算器

Pimozide-d5 N-Oxide 是 Pimozide 的氘代物。Pimozide 是 dopamine receptor 的拮抗剂，对 dopamine D2，D3 和 D1 受体的 Ki 值分别为 1.4 nM，2.5 nM 和 588 nM，同时对 α1-adrenoceptor 也有较高亲和性，Ki 值为 39 nM；Pimozide 也是 STAT3 和 STAT5 的抑制剂。

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Pimozide-d<sub>5</sub> N-Oxide Chemical Structure

Pimozide-d5 N-Oxide Chemical Structure

CAS No. : 1794795-40-6

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Other Forms of Pimozide-d5 N-Oxide:

Pimozide-d5 N-Oxide 相关抗体

Top Publications Citing Use of Products

查看 Dopamine Receptor 亚型特异性产品:

查看所有亚型
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

查看 Adrenergic Receptor 亚型特异性产品:

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α adrenergic receptor β adrenergic receptor

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pimozide-d5 N-Oxide is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5[1][2].

IC50 & Target

D1 Receptor

 

D3 Receptor

 

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pimozide-d5 N-Oxide 相关抗体:
分子量

482.58

Formula

C28H24D5F2N3O2
CAS 号
非标记 CAS

2062-78-4
中文名称

匹莫齐特 d5（N 氧化物）
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pimozide-d5 N-Oxide 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pimozide-d5 N-Oxide1794795-40-6匹莫齐特 d5（N 氧化物）Isotope-Labeled CompoundsDopamine ReceptorAdrenergic ReceptorSTATBeta ReceptorInhibitorinhibitorinhibit

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