Polzastobart  (Synonyms: JTX 8064)

Polzastobart (JTX-8064) is a humanized IgG4 monoclonal antagonist antibody that selectively binds LILRB2 and prevents it from binding its ligands, classical and non-classical MHC I molecules. Polzastobart enhances pro-inflammatory cytokine production in macrophages by blocking the ability of LILRB2 to bind HLA-A/B and/or HLA-G, a marker of immunotolerance on cancer cells. Polzastobart is a macrophage immune checkpoint inhibitor^[1].

Human IgG4 kappa

Human IgG4 (S228P) kappa, Isotype Control

Humanized

LILRB2

2640981-19-5

液体

Colorless to light yellow

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

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  Human IgG4 kappa

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  Immobilized LILRB2/CD85d/ILT-4 Protein, Human can bind Polzastobart. The EC₅₀ for this effect is 8.336 ng/mL.

• [1]. Kyriakos P. Papadopoulos, et al. Phase 1, first-in-human trial of JTX-8064, an anti-LILRB2/ILT4 monoclonal antibody, as monotherapy and in combination with anti-PD-1 in adult patients with advanced solid tumors (INNATE).