2. Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK PROTAC Apoptosis
  3. CDK FLT3 PROTACs Apoptosis
  4. PROTAC FLT3/CDK9 degrader-1

PROTAC FLT3/CDK9 degrader-1 是一种有效的 FLT3 和 CDK9 双 PROTAC 降解剂。PROTAC FLT3/CDK9 degrader-1 诱导细胞凋亡 (Apoptosis) 并有效降解靶蛋白 FLT3 和 CDK9。PROTAC FLT3/CDK9 degrader-1具有研究 FLT3-ITD 突变型 AML 的潜力。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PROTAC FLT3/CDK9 degrader-1 Chemical Structure

PROTAC FLT3/CDK9 degrader-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

PROTAC FLT3/CDK9 degrader-1 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC FLT3/CDK9 degrader-1 is a potent FLT3 and CDK9 dual PROTAC degrader. PROTAC FLT3/CDK9 degrader-1 induces apoptosis and effective degradation of target proteins FLT3 and CDK9. PROTAC FLT3/CDK9 degrader-1 has the potential for the research of FLT3-ITD mutated AML[1].

体外研究
(In Vitro)

PROTAC FLT3/CDK9 degrader-1 (compound PROTAC 13) (0.004, 0.02, 0.1, 0.5, 2.5 µM; 16 h) 降低 p-FLT3 Y589/591、p-STAT5 Y694、p-ERK1/2 T202/Y204 的表达,并以剂量依赖性方式诱导 MV4-11 细胞凋亡[1]。
在 MV4-11 细胞中用 MG132 (HY-13259) (0.2 µM) 预处理 90 分钟后，PROTAC FLT3/CDK9 degrader-1 (0, 0.1, 0.5 µM; 16 h) 的蛋白降解能力减弱[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC FLT3/CDK9 degrader-1 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MV4-11, MV4-11 CRBN-def., MOLM-13, RS4-11, HL60, U937, THP-1, Kasumi-1, CEM, K562 cells
Concentration: 0-10 µM
Incubation Time: 72 h
Result: Showed antiproliferative activity with IC50s of 0.047, 0.119, 0.042, 1.014, 6.122, 9.507, 9.993, >10, >10, >10 µM for MV4-11, MV4-11 CRBN-def., MOLM-13, RS4-11, HL60, U937, THP-1, Kasumi-1, CEM, K562 cells, respectively.

Western Blot Analysis[1]

Cell Line: MV4-11 cells
Concentration: 0.004, 0.02, 0.1, 0.5, 2.5 µM
Incubation Time: 16 h
Result: Decreased the expression of p-FLT3 Y589/591, p-STAT5 Y694, p-ERK1/2 T202/Y204 in a dose-depent manner.

Apoptosis Analysis[1]

Cell Line: MV4-11, CRBN-deficient MV4-11 cells
Concentration: 0.004, 0.02, 0.1, 0.5, 2.5 µM
Incubation Time: 16 h
Result: Induced apoptosis with the activities of caspases 3 and 7 increased in a concentration-dependent manner in MV4-11 cells.
分子量

920.07

Formula

C47H61N13O7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC FLT3/CDK9 degrader-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC FLT3/CDK9 degrader-1CDKFLT3PROTACsApoptosisCyclin dependent kinaseCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3apoptosisCDK9MV4-11caspases 3/7AMLInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
PROTAC FLT3/CDK9 degrader-1
目录号：
HY-148521
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z