1. PROTAC Epigenetics
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  3. PROTAC SMARCA2/4-degrader-30

PROTAC SMARCA2/4-degrader-30 (Compound I-291) 是 SWI/SNF 复合体的催化亚基 SMARCA2SMARCA4 的降解剂。PROTAC SMARCA2/4-degrader-30 在 MV411 和 A549 中降解 SMARCA2DC50 <100 nM;在 MV411 中降解 SMARCA4DC50 <100 nM。(粉色:靶蛋白配体 (HY-163926);黑色:连接子 (HY-159684);蓝色:E3 连接酶配体 (HY-W382038))

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PROTAC SMARCA2/4-degrader-30 Chemical Structure

PROTAC SMARCA2/4-degrader-30 Chemical Structure

CAS No. : 2568276-44-6

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  • 生物活性

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生物活性

PROTAC SMARCA2/4-degrader-30 (Compound I-291) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-30 degrades SMARCA2 in A549 and in MV411 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 <100 nM. (Pink: ligand for target protein (HY-163926); Black: linker (HY-159684); Blue: ligand for E3 ligase (HY-W382038))[1].

分子量

797.95

Formula

C44H51N11O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
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产品名称:
PROTAC SMARCA2/4-degrader-30
目录号:
HY-162748
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