2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. PROTAC SMARCA2/4-degrader-6

PROTAC SMARCA2/4-degrader-6 (compound I-438) 是一种 SMARCA2/4 降解剂。PROTAC SMARCA2/4-degrader-6 具有用于癌症研究的潜力 (蓝色: SMARCA2/4 配体, (HY-159545); 黑色: 连接子, (HY-W006635); 粉色: VHL 配体,( HY-112078))。

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PROTAC SMARCA2/4-degrader-6 Chemical Structure

PROTAC SMARCA2/4-degrader-6 Chemical Structure

CAS No. : 2568277-87-0

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PROTAC SMARCA2/4-degrader-6 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC SMARCA2/4-degrader-6 (compound I-438) is a SMARCA2/4 degrader. PROTAC SMARCA2/4-degrader-6 has the potential for the research of cancer. (Blue:SMARCA2/4 ligand, (HY-159545); Black: linker (HY-W006635); Pink:VHL ligand (HY-112078))[1].

体外研究
(In Vitro)

PROTAC SMARCA2/4-degrader-6 (compound I-438) (0-1000 nM; 24 h) 诱导 MV4-11 细胞中的 SMARCA2、SMARCA4 蛋白质降解，对 SMARCA2 和 SMARCA4 的 DC50 值分别为 <100、<100 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC SMARCA2/4-degrader-6 相关抗体:
分子量

928.16

Formula

C50H61N11O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC SMARCA2/4-degrader-6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SMARCA2/4-degrader-62568277-87-0PROTACsEpigenetic Reader DomainMV4-11 cellscancerInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-159457
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