2. Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related Anti-infection
  3. Topoisomerase ADC Cytotoxin Antibiotic
  4. Rebeccamycin

Rebeccamycin，一种抗肿瘤抗生素，抑制 DNA 拓扑异构酶 I (DNA topoisomerase I)。Rebeccamycin 通过毒害拓扑异构酶 I 发挥其主要的抗肿瘤作用，对蛋白激酶 C 和拓扑异构酶 Ⅱ 的作用较小。

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Rebeccamycin Chemical Structure

Rebeccamycin Chemical Structure

CAS No. : 93908-02-2

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规格 价格 是否有货 数量
1 mg 询价
2.5 mg 询价
250 μg 询价
500 μg ￥3758
3 - 4 周
500 μg 询价
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Rebeccamycin 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

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Topoisomerase Topo I Topo II

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II[1][2].

IC50 & Target[1]

Topoisomerase I

 

Traditional Cytotoxic Agents

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CEM-SS IC50
0.52 μM
Compound: 1 (Rebeccamycin)
Anti-HIV-1 activity in CEM-SS cells was measured by the quantification of the reverse transcriptase activity, associated with the virus particles released from HIV-1 infected cells in the culture medium.
Anti-HIV-1 activity in CEM-SS cells was measured by the quantification of the reverse transcriptase activity, associated with the virus particles released from HIV-1 infected cells in the culture medium.
[PMID: 10052965]
L1210 IC50
0.14 μM
Compound: Rebeccamycin
Cytotoxicity activity against mouse L1210 cells by MTT assay
Cytotoxicity activity against mouse L1210 cells by MTT assay
[PMID: 20566289]
体外研究
(In Vitro)

Rebeccamycin is an antitumor antibiotic produced by the actinomycete Saccharotrix aerocolonigenes with activity against several human tumor cell lines, including A549 (lung adenocarcinoma), HCT-116 (colon carcinoma), and KB (nasopharyngeal carcinoma) [1].
Rebeccamycin shows antibacterial activity against several Gram-positive bacteria, including Staphylococcus aureus and Streptococcus faecalis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Rebeccamycin 相关抗体:
体内研究
(In Vivo)

Rebeccamycin (2-256 mg/kg; i.p.; daily for 9 days) prolongs survival in B16 melanoma, L1210 leukemia[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CDF1 mice (B16 melanoma, L1210 leukemia)[2]
Dosage: 2, 4, 8, 16, 32, 64, 128, 256 mg/kg
Administration: I.p.; daily for 9 days
Result: Prolongation of survival of the mice at dose levels ranging from 8 to 256 mg/kg.
分子量

570.38

Formula

C27H21Cl2N3O7
CAS 号
结构分类
初始来源

the mycelium
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Rebeccamycin 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rebeccamycin93908-02-2TopoisomeraseADC CytotoxinAntibioticADC PayloadantineoplasticantitumorA549HCT-116cellsB16melanomaL1210leukemiaInhibitorinhibitorinhibit

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