Rp-8-Br-cAMPS sodium 

Rp-8-Br-cAMPS sodium is an analog of cAMP and an inhibitor of PKA. Rp-8-Br-cAMPS sodium occupies cAMP binding sites on PKA type I regulatory subunits, thereby preventing PKA dissociation and activation. Rp-8-Br-cAMPS sodium can be used in the study of tumors and retrovirus-induced immune deficiency. Rp-8-Br-cAMPS sodium also inhibits insulin secretion^[1][2][3].

Rp-8-Br-cAMPS (1 mM；4-6 小时) 可以完全阻断 2-chloroadenosine (HY-W008344) 抑制 LAK 细胞毒性的能力，以及显著减轻 2-chloroadenosine (HY-W008344) 对细胞因子产生的抑制作用^[1]。
Rp-8-Br-cAMPS (50-100 μM；2 分钟 ) 在 832/13 细胞 (来源于 INS-1 细胞) 中抑制胰岛素的分泌^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Rp-8-Br-cAMPS (1 mg；腹腔注射；10 天) 在小鼠逆转录病毒感染模型中可以改善小鼠的免疫功能^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

446.15

C₁₀H₁₀BrN₅NaO₅PS

925456-59-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Raskovalova T, et al. Adenosine-mediated inhibition of cytotoxic activity and cytokine production by IL-2/NKp46-activated NK cells: involvement of protein kinase A isozyme I (PKA I). Immunol Res. 2006;36(1-3):91-9.  [Content Brief]

  [2]. Yang S, et al. Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin-producing beta-cell line (INS-1 832/13). Mol Endocrinol. 2004 Sep;18(9):2312-20.  [Content Brief]

  [3]. Nayjib B, et al. In vivo administration of a PKA type I inhibitor (Rp-8-Br-cAMPS) restores T-cell responses in retrovirus-infected mice[J]. The Open Immunology Journal, 2008, 1(1).