2. Stem Cell/Wnt TGF-beta/Smad
  3. PKA
  4. Rp-8-Br-cAMPS

Rp-8-Br-cAMPS 是 cAMP 的类似物和 PKA 的抑制剂。Rp-8-Br-cAMPS 可占据 PKA I 型调节亚基上的 cAMP 结合位点，从而阻止 PKA 的解离和激活。Rp-8-Br-cAMPS 可用于肿瘤和逆转录病毒诱导的免疫缺陷的研究。Rp-8-Br-cAMPS 还可以抑制胰岛素的分泌。

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Rp-8-Br-cAMPS Chemical Structure

Rp-8-Br-cAMPS Chemical Structure

CAS No. : 129735-00-8

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Other Forms of Rp-8-Br-cAMPS:

Rp-8-Br-cAMPS 相关抗体

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PKA PKAR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rp-8-Br-cAMPS is an analog of cAMP and an inhibitor of PKA. Rp-8-Br-cAMPS occupies cAMP binding sites on PKA type I regulatory subunits, thereby preventing PKA dissociation and activation. Rp-8-Br-cAMPS can be used in the study of tumors and retrovirus-induced immune deficiency. Rp-8-Br-cAMPS also inhibits insulin secretion[1][2][3].

体外研究
(In Vitro)

Rp-8-Br-cAMPS (1 mM；4-6 小时) 可以完全阻断 2-chloroadenosine (HY-W008344) 抑制 LAK 细胞毒性的能力，以及显著减轻 2-chloroadenosine (HY-W008344) 对细胞因子产生的抑制作用[1]。
Rp-8-Br-cAMPS (50-100 μM；2 分钟 ) 在 832/13 细胞 (来源于 INS-1 细胞) 中抑制胰岛素的分泌[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Rp-8-Br-cAMPS 相关抗体:
体内研究
(In Vivo)

Rp-8-Br-cAMPS (1 mg；腹腔注射；10 天) 在小鼠逆转录病毒感染模型中可以改善小鼠的免疫功能[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine leukemia retrovirus RadLV-Rs treated male C57BL/6 mice[3]
Dosage: 1 mg
Administration: Intraperitoneal injection (i.p.); 10 days
Result: Had no significant effect on the extent of lymphadenopathy and splenomegaly which is typical of RadLV-Rs retroviral infection.
Strongly increased responses to the anti-CD3 mAb.
Improved T cell responses.
分子量

424.17

Formula

C10H11BrN5O5PS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Rp-8-Br-cAMPS 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rp-8-Br-cAMPS129735-00-8PKAProtein kinase Amurine AIDSMAIDSanergyRadLV-RsINS-1 cellsLAK cellsInhibitorinhibitorinhibit

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