2. Antibody-drug Conjugate/ADC Related Anti-infection
  3. ADC Cytotoxin Bacterial Antibiotic
  4. Sandramycin

Sandramycin  (Synonyms: 山卓霉素)

目录号: HY-19829
产品使用指南

摩尔计算器

Sandramycin 是一种从 Nocardioides sp 的培养液中分离出来的一种环状十肽抗菌素。Sandramycin 也可以有效地结合 DNA，并且是一种 ADC 的毒素分子。Sandramycin 对革兰氏阳性细菌 (Gram-positive bacteria) 具有活性，并具有有效的抗肿瘤活性。

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Sandramycin Chemical Structure

Sandramycin Chemical Structure

CAS No. : 100940-65-6

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规格 价格 是否有货 数量
5 mg 询价
1 mg 现货 3 - 4 周

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Sandramycin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity[1][2][3].

IC50 & Target[1]

Traditional Cytotoxic Agents

 

体外研究
(In Vitro)

Sandramycin has antimicrobial activity wtih MIC values of 0.024 μg/mL, 0.012 μg/mL, 0.012 μg/mL, 0.098 μg/mL, 0.024 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Bacillus subtilis (Rec+) A22508-2, B. subtilis (Rec-) A22509-2-2, Staphylocccus aureus 209P-A9497, S. aureus (echinomycin-resistant) A9628, Streptococcus faecalis A96 1 1, Escherichia coli A151 19 and E. coli (actinomycin-sensitive) A21780 (AS-19), respectively[1].
Sandramycin inhibits cancer cells growth of L1210, B16, HCT118, RPMI8226, A431, RKO, SU-DHL6 and SU-DHL10 cells with IC50 values of 0.02 nM, 0.07 nM, 0.8 nM, 3.8 nM, 3.1 nM, 1.3 nM, 5.9 nM and 3.3 nM, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sandramycin 相关抗体:
体内研究
(In Vivo)

Sandramycin (0.0125-1.6 mg/kg; intraperitoneal injection; daily; for 5 days; CDF1 female mice) treatment shows moderately active in vivo against leukemia P388 in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CDF1 female mice injected with leukemia P388 cells[1]
Dosage: 0.0125 mg/kg, 0.025 mg/kg, 0.05 mg/kg, 0.1 mg/kg, 0.2 mg/kg, 0.4 mg/kg, 0.8 mg/kg, 1.6 mg/kg
Administration: Intraperitoneal injection; daily; for 5 days
Result: Was moderately active in vivo against leukemia P388 in mice.
分子量

1221.32

Formula

C60H76N12O16
CAS 号
中文名称

山卓霉素
结构分类
初始来源

Nocardioides sp.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sandramycin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sandramycin100940-65-6山卓霉素ADC CytotoxinBacterialAntibioticADC PayloadDNAintercalatordepsipeptideantibioticantitumorGram-positivebis-intercalationCytotoxinADCInhibitorinhibitorinhibit

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