2. Immunology/Inflammation TGF-beta/Smad
  3. PD-1/PD-L1 TGF-β Receptor
  4. SHR-1701

SHR-1701  (Synonyms: Retlirafusp alfa)

目录号: HY-P99944 纯度: 99.77%
COA

摩尔计算器

SHR-1701 (Retlirafusp alfa) 是一种靶向 PD-L1 和 TGF β 的双功能融合蛋白，可用于癌症研究。

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CAS No. : 2891860-17-4

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规格 价格 是否有货 数量
1 mg ￥3600
In-stock
5 mg ￥9400
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

SHR-1701 相关抗体

Top Publications Citing Use of Products

查看 TGF-β Receptor 亚型特异性产品:

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ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SHR-1701 (Retlirafusp alfa) is a bifunctional fusion protein targeting PD-L1 and TGF-β for cancer research[1].

体外研究
(In Vitro)

SHR-1701 (10 μg/mL)可以抑制 TGF-β 信号通路，激活 PI3K/Akt/Erk 信号通路，挽救淋巴细胞恢复受损的肺癌患者外周血CD8+ T 细胞的抗肿瘤功能[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SHR-1701 相关抗体:
分子量

33.07

Formula

HS
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Immobilized Human PD-L1/B7-H1 Protein (ECD, His Tag) can bind SHR-1701. The EC50 for this effect is 0.42 ng/mL.
纯度 & 产品资料
参考文献

SHR-1701 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SHR-17012891860-17-4Retlirafusp alfaSHR1701SHR 1701PD-1/PD-L1TGF-β ReceptorPD-1/Programmed death-ligand 1Transforming growth factor beta receptorsPD-L1TGF-βcancerInhibitorinhibitorinhibit

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