2. Apoptosis
  3. Apoptosis
  4. Sophoraflavanone G

Sophoraflavanone G  (Synonyms: Kushenol F)

目录号: HY-N1231 纯度: 99.52%
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摩尔计算器

Sophoraflavanone G (Kushenol F) 是从苦参中提取得到的，具有抗肿瘤和抗炎特性。Sophoraflavanone G (Kushenol F) 通过抑制 MAPK 相关途径诱导 MDA-MB-231 和 HL-60 细胞凋亡 (apoptosis)。

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Sophoraflavanone G Chemical Structure

Sophoraflavanone G Chemical Structure

CAS No. : 97938-30-2

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1 mg ￥394
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5 mg ￥900
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10 mg ￥1400
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25 mg ￥2475
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50 mg ￥3713
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Other Forms of Sophoraflavanone G:

Sophoraflavanone G 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties.? Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways[1][2].

IC50 & Target

IC50: 29.7 μM (MDA-MB-231 cell)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
202.07 nM
Compound: SFG
Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 552.97 +/-106.74 nM)
Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 552.97 +/-106.74 nM)
[PMID: 34496204]
A549 IC50
21.28 μM
Compound: SFG
Cytotoxicity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
[PMID: 34496204]
A549 IC50
212.41 nM
Compound: SFG
Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 1625.4 +/-413.42 nM)
Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 1625.4 +/-413.42 nM)
[PMID: 34496204]
A549 IC50
26.19 μM
Compound: SFG
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
[PMID: 34496204]
A549 IC50
318.48 nM
Compound: SFG
Chemo-sensitizing activity against human A549 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 376.13 +/-60.17 nM)
Chemo-sensitizing activity against human A549 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 376.13 +/-60.17 nM)
[PMID: 34496204]
A549 IC50
329.75 nM
Compound: SFG
Chemo-sensitizing activity against human A549 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 376.13 +/-60.17 nM)
Chemo-sensitizing activity against human A549 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 376.13 +/-60.17 nM)
[PMID: 34496204]
A549 IC50
382.31 nM
Compound: SFG
Chemo-sensitizing activity against human A549 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 376.13 +/-60.17 nM)
Chemo-sensitizing activity against human A549 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 376.13 +/-60.17 nM)
[PMID: 34496204]
A549 IC50
397.71 nM
Compound: SFG
Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 1162.92 +/-250.73 nM)
Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 1162.92 +/-250.73 nM)
[PMID: 34496204]
A549 IC50
403.35 nM
Compound: SFG
Chemo-sensitizing activity against human A549 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb =555.44 +/-125.7 nM)
Chemo-sensitizing activity against human A549 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb =555.44 +/-125.7 nM)
[PMID: 34496204]
A549 IC50
46.29 nM
Compound: SFG
Chemo-sensitizing activity against human A549 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 82.47 +/-24.25 nM)
Chemo-sensitizing activity against human A549 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 82.47 +/-24.25 nM)
[PMID: 34496204]
A549 IC50
471.59 nM
Compound: SFG
Chemo-sensitizing activity against human A549 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb =555.44 +/-125.7 nM)
Chemo-sensitizing activity against human A549 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb =555.44 +/-125.7 nM)
[PMID: 34496204]
A549 IC50
509.94 nM
Compound: SFG
Chemo-sensitizing activity against human A549 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb =555.44 +/-125.7 nM)
Chemo-sensitizing activity against human A549 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb =555.44 +/-125.7 nM)
[PMID: 34496204]
A549 IC50
52.61 nM
Compound: SFG
Chemo-sensitizing activity against human A549 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 82.47 +/-24.25 nM)
Chemo-sensitizing activity against human A549 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 82.47 +/-24.25 nM)
[PMID: 34496204]
A549 IC50
60.52 nM
Compound: SFG
Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 552.97 +/-106.74 nM)
Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 552.97 +/-106.74 nM)
[PMID: 34496204]
A549 IC50
603.57 nM
Compound: SFG
Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 1625.4 +/-413.42 nM)
Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 1625.4 +/-413.42 nM)
[PMID: 34496204]
A549 IC50
629.51 nM
Compound: SFG
Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 1162.92 +/-250.73 nM)
Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 1162.92 +/-250.73 nM)
[PMID: 34496204]
A549 IC50
67.97 nM
Compound: SFG
Chemo-sensitizing activity against human A549 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 82.47 +/-24.25 nM)
Chemo-sensitizing activity against human A549 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 82.47 +/-24.25 nM)
[PMID: 34496204]
A549 IC50
692.66 nM
Compound: SFG
Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 1162.92 +/-250.73 nM)
Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 1162.92 +/-250.73 nM)
[PMID: 34496204]
A549 IC50
93.7 nM
Compound: SFG
Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 552.97 +/-106.74 nM)
Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 552.97 +/-106.74 nM)
[PMID: 34496204]
A549 IC50
980.34 nM
Compound: SFG
Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 1625.4 +/-413.42 nM)
Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 1625.4 +/-413.42 nM)
[PMID: 34496204]
HEK293 IC50
1.04 μM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 1.31 +/-0.2 microM)
Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 1.31 +/-0.2 microM)
[PMID: 34496204]
HEK293 IC50
1.05 μM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 1.31 +/-0.2 microM)
Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 1.31 +/-0.2 microM)
[PMID: 34496204]
HEK293 IC50
1.56 μM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 1.31 +/-0.2 microM)
Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 1.31 +/-0.2 microM)
[PMID: 34496204]
HEK293 IC50
1062.4 nM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 787.11 +/-227.51 nM)
Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 787.11 +/-227.51 nM)
[PMID: 34496204]
HEK293 IC50
112.05 nM
Compound: SFG
Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 239.91 +/-25 nM)
Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 239.91 +/-25 nM)
[PMID: 34496204]
HEK293 IC50
112.37 nM
Compound: SFG
Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 558.68 +/-81.31 nM)
Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 558.68 +/-81.31 nM)
[PMID: 34496204]
HEK293 IC50
15.23 nM
Compound: SFG
Chemo-sensitizing activity against human HEK293 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 15.36 +/-6.18 nM)
Chemo-sensitizing activity against human HEK293 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 15.36 +/-6.18 nM)
[PMID: 34496204]
HEK293 IC50
15.38 nM
Compound: SFG
Chemo-sensitizing activity against human HEK293 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 15.36 +/-6.18 nM)
Chemo-sensitizing activity against human HEK293 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 15.36 +/-6.18 nM)
[PMID: 34496204]
HEK293 IC50
17.01 nM
Compound: SFG
Chemo-sensitizing activity against human HEK293 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 15.36 +/-6.18 nM)
Chemo-sensitizing activity against human HEK293 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 15.36 +/-6.18 nM)
[PMID: 34496204]
HEK293 IC50
17.86 nM
Compound: SFG
Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 99.55 +/-7.35 nM)
Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 99.55 +/-7.35 nM)
[PMID: 34496204]
HEK293 IC50
2.28 nM
Compound: SFG
Chemo-sensitizing activity against human HEK293 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 2.29 +/-0.35 nM)
Chemo-sensitizing activity against human HEK293 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 2.29 +/-0.35 nM)
[PMID: 34496204]
HEK293 IC50
2.4 nM
Compound: SFG
Chemo-sensitizing activity against human HEK293 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 2.74 +/-0.69 nM)
Chemo-sensitizing activity against human HEK293 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 2.74 +/-0.69 nM)
[PMID: 34496204]
HEK293 IC50
2.48 nM
Compound: SFG
Chemo-sensitizing activity against human HEK293 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.67 +/-0.39 nM)
Chemo-sensitizing activity against human HEK293 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.67 +/-0.39 nM)
[PMID: 34496204]
HEK293 IC50
2.61 nM
Compound: SFG
Chemo-sensitizing activity against human HEK293 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.67 +/-0.39 nM)
Chemo-sensitizing activity against human HEK293 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.67 +/-0.39 nM)
[PMID: 34496204]
HEK293 IC50
2.65 nM
Compound: SFG
Chemo-sensitizing activity against human HEK293 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 2.29 +/-0.35 nM)
Chemo-sensitizing activity against human HEK293 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 2.29 +/-0.35 nM)
[PMID: 34496204]
HEK293 IC50
2.7 nM
Compound: SFG
Chemo-sensitizing activity against human HEK293 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.67 +/-0.39 nM)
Chemo-sensitizing activity against human HEK293 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.67 +/-0.39 nM)
[PMID: 34496204]
HEK293 IC50
2.76 nM
Compound: SFG
Chemo-sensitizing activity against human HEK293 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 2.78 +/-0.58 nM)
Chemo-sensitizing activity against human HEK293 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 2.78 +/-0.58 nM)
[PMID: 34496204]
HEK293 IC50
2.83 nM
Compound: SFG
Chemo-sensitizing activity against human HEK293 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 2.78 +/-0.58 nM)
Chemo-sensitizing activity against human HEK293 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 2.78 +/-0.58 nM)
[PMID: 34496204]
HEK293 IC50
2.86 nM
Compound: SFG
Chemo-sensitizing activity against human HEK293 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 2.74 +/-0.69 nM)
Chemo-sensitizing activity against human HEK293 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 2.74 +/-0.69 nM)
[PMID: 34496204]
HEK293 IC50
2.95 nM
Compound: SFG
Chemo-sensitizing activity against human HEK293 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 2.74 +/-0.69 nM)
Chemo-sensitizing activity against human HEK293 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 2.74 +/-0.69 nM)
[PMID: 34496204]
HEK293 IC50
2.99 nM
Compound: SFG
Chemo-sensitizing activity against human HEK293 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 2.78 +/-0.58 nM)
Chemo-sensitizing activity against human HEK293 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 2.78 +/-0.58 nM)
[PMID: 34496204]
HEK293 IC50
238.94 nM
Compound: SFG
Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 558.68 +/-81.31 nM)
Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 558.68 +/-81.31 nM)
[PMID: 34496204]
HEK293 IC50
3.59 nM
Compound: SFG
Chemo-sensitizing activity against human HEK293 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 2.29 +/-0.35 nM)
Chemo-sensitizing activity against human HEK293 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 2.29 +/-0.35 nM)
[PMID: 34496204]
HEK293 IC50
31.5 nM
Compound: SFG
Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 99.55 +/-7.35 nM)
Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 99.55 +/-7.35 nM)
[PMID: 34496204]
HEK293 IC50
314.87 nM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 260 +/-74.23 nM)
Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 260 +/-74.23 nM)
[PMID: 34496204]
HEK293 IC50
323.75 nM
Compound: SFG
Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 558.68 +/-81.31 nM)
Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 558.68 +/-81.31 nM)
[PMID: 34496204]
HEK293 IC50
329.16 nM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 260 +/-74.23 nM)
Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 260 +/-74.23 nM)
[PMID: 34496204]
HEK293 IC50
35.13 μM
Compound: SFG
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
[PMID: 34496204]
HEK293 IC50
358.29 nM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 787.11 +/-227.51 nM)
Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 787.11 +/-227.51 nM)
[PMID: 34496204]
HEK293 IC50
37.55 nM
Compound: SFG
Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 239.91 +/-25 nM)
Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 239.91 +/-25 nM)
[PMID: 34496204]
HEK293 IC50
38.19 nM
Compound: SFG
Chemo-sensitizing activity against human HEK293 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 35.17 +/-8.65 nM)
Chemo-sensitizing activity against human HEK293 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 35.17 +/-8.65 nM)
[PMID: 34496204]
HEK293 IC50
38.88 nM
Compound: SFG
Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 99.55 +/-7.35 nM)
Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 99.55 +/-7.35 nM)
[PMID: 34496204]
HEK293 IC50
40.08 nM
Compound: SFG
Chemo-sensitizing activity against human HEK293 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 35.17 +/-8.65 nM)
Chemo-sensitizing activity against human HEK293 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 35.17 +/-8.65 nM)
[PMID: 34496204]
HEK293 IC50
41.99 nM
Compound: SFG
Chemo-sensitizing activity against human HEK293 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 35.17 +/-8.65 nM)
Chemo-sensitizing activity against human HEK293 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 35.17 +/-8.65 nM)
[PMID: 34496204]
HEK293 IC50
416.09 nM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 260 +/-74.23 nM)
Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 260 +/-74.23 nM)
[PMID: 34496204]
HEK293 IC50
49.7 μM
Compound: SFG
Cytotoxicity against ABCG2-overexpressing human HEK293/482R cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against ABCG2-overexpressing human HEK293/482R cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
[PMID: 34496204]
HEK293 IC50
847.09 nM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 787.11 +/-227.51 nM)
Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 787.11 +/-227.51 nM)
[PMID: 34496204]
HEK293 IC50
99.94 nM
Compound: SFG
Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 239.91 +/-25 nM)
Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 239.91 +/-25 nM)
[PMID: 34496204]
HL-60 IC50
12.5 μM
Compound: 3
Cytotoxicity against human HL60 cells after 96 hrs by MTT assay
Cytotoxicity against human HL60 cells after 96 hrs by MTT assay
[PMID: 10843587]
KB 3-1 IC50
0.72 nM
Compound: SFG
Chemo-sensitizing activity against human KB 3-1 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1.19 +/-0.39 nM)
Chemo-sensitizing activity against human KB 3-1 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1.19 +/-0.39 nM)
[PMID: 34496204]
KB 3-1 IC50
0.97 nM
Compound: SFG
Chemo-sensitizing activity against human KB 3-1 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1.19 +/-0.39 nM)
Chemo-sensitizing activity against human KB 3-1 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1.19 +/-0.39 nM)
[PMID: 34496204]
KB 3-1 IC50
1.08 nM
Compound: SFG
Chemo-sensitizing activity against human KB 3-1 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1.19 +/-0.39 nM)
Chemo-sensitizing activity against human KB 3-1 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1.19 +/-0.39 nM)
[PMID: 34496204]
KB 3-1 IC50
12.44 nM
Compound: SFG
Chemo-sensitizing activity against human KB 3-1 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 13.78 +/-7.63 nM)
Chemo-sensitizing activity against human KB 3-1 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 13.78 +/-7.63 nM)
[PMID: 34496204]
KB 3-1 IC50
13.02 nM
Compound: SFG
Chemo-sensitizing activity against human KB 3-1 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 13.78 +/-7.63 nM)
Chemo-sensitizing activity against human KB 3-1 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 13.78 +/-7.63 nM)
[PMID: 34496204]
KB 3-1 IC50
13.2 nM
Compound: SFG
Chemo-sensitizing activity against human KB 3-1 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 13.78 +/-7.63 nM)
Chemo-sensitizing activity against human KB 3-1 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 13.78 +/-7.63 nM)
[PMID: 34496204]
KB 3-1 IC50
2.1 nM
Compound: SFG
Chemo-sensitizing activity against human KB 3-1 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.29 +/-0.75 nM)
Chemo-sensitizing activity against human KB 3-1 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.29 +/-0.75 nM)
[PMID: 34496204]
KB 3-1 IC50
2.14 nM
Compound: SFG
Chemo-sensitizing activity against human KB 3-1 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.29 +/-0.75 nM)
Chemo-sensitizing activity against human KB 3-1 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.29 +/-0.75 nM)
[PMID: 34496204]
KB 3-1 IC50
2.6 nM
Compound: SFG
Chemo-sensitizing activity against human KB 3-1 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.29 +/-0.75 nM)
Chemo-sensitizing activity against human KB 3-1 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.29 +/-0.75 nM)
[PMID: 34496204]
KB-V1 IC50
1.7 μM
Compound: SFG
Chemo-sensitizing activity against ABCB1-expressing human KB-V1 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.73 +/-0.42 microM)
Chemo-sensitizing activity against ABCB1-expressing human KB-V1 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.73 +/-0.42 microM)
[PMID: 34496204]
KB-V1 IC50
1367.2 nM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1745 +/-293.01 nM)
Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1745 +/-293.01 nM)
[PMID: 34496204]
KB-V1 IC50
1524.22 nM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1745 +/-293.01 nM)
Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1745 +/-293.01 nM)
[PMID: 34496204]
KB-V1 IC50
1724.3 nM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1745 +/-293.01 nM)
Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1745 +/-293.01 nM)
[PMID: 34496204]
KB-V1 IC50
2.32 μM
Compound: SFG
Chemo-sensitizing activity against ABCB1-expressing human KB-V1 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.73 +/-0.42 microM)
Chemo-sensitizing activity against ABCB1-expressing human KB-V1 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.73 +/-0.42 microM)
[PMID: 34496204]
KB-V1 IC50
3.08 μM
Compound: SFG
Chemo-sensitizing activity against ABCB1-expressing human KB-V1 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.73 +/-0.42 microM)
Chemo-sensitizing activity against ABCB1-expressing human KB-V1 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.73 +/-0.42 microM)
[PMID: 34496204]
KB-V1 IC50
822.27 nM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 758.22 +/-156.56 nM)
Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 758.22 +/-156.56 nM)
[PMID: 34496204]
KB-V1 IC50
865.61 nM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 758.22 +/-156.56 nM)
Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 758.22 +/-156.56 nM)
[PMID: 34496204]
KB-V1 IC50
978.02 nM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 758.22 +/-156.56 nM)
Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 758.22 +/-156.56 nM)
[PMID: 34496204]
NCI/ADR-RES IC50
3.04 μM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 2.63 +/-0.62 microM)
Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 2.63 +/-0.62 microM)
[PMID: 34496204]
NCI/ADR-RES IC50
3.37 μM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 2.63 +/-0.62 microM)
Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 2.63 +/-0.62 microM)
[PMID: 34496204]
NCI/ADR-RES IC50
3.51 μM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 2.63 +/-0.62 microM)
Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 2.63 +/-0.62 microM)
[PMID: 34496204]
NCI/ADR-RES IC50
4.92 μM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 7.09 +/-0.89 microM)
Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 7.09 +/-0.89 microM)
[PMID: 34496204]
NCI/ADR-RES IC50
4.95 μM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 5.57 +/-0.96 microM)
Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 5.57 +/-0.96 microM)
[PMID: 34496204]
NCI/ADR-RES IC50
5.43 μM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 5.57 +/-0.96 microM)
Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 5.57 +/-0.96 microM)
[PMID: 34496204]
NCI/ADR-RES IC50
5.58 μM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 5.57 +/-0.96 microM)
Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 5.57 +/-0.96 microM)
[PMID: 34496204]
NCI/ADR-RES IC50
6.18 μM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 7.09 +/-0.89 microM)
Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 7.09 +/-0.89 microM)
[PMID: 34496204]
NCI/ADR-RES IC50
7.04 μM
Compound: SFG
Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 7.09 +/-0.89 microM)
Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 7.09 +/-0.89 microM)
[PMID: 34496204]
NCI-H460 IC50
0.43 μM
Compound: SFG
Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 4.33 +/-1.18 microM)
Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 4.33 +/-1.18 microM)
[PMID: 34496204]
NCI-H460 IC50
1.16 μM
Compound: SFG
Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 4.33 +/-1.18 microM)
Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 4.33 +/-1.18 microM)
[PMID: 34496204]
NCI-H460 IC50
1.64 μM
Compound: SFG
Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 4.33 +/-1.18 microM)
Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 4.33 +/-1.18 microM)
[PMID: 34496204]
NCI-H460 IC50
100.27 nM
Compound: SFG
Chemo-sensitizing activity against human NCI-H460 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 128.27 +/-22.6 nM)
Chemo-sensitizing activity against human NCI-H460 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 128.27 +/-22.6 nM)
[PMID: 34496204]
NCI-H460 IC50
127.03 nM
Compound: SFG
Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 963.32 +/-120.89 nM)
Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 963.32 +/-120.89 nM)
[PMID: 34496204]
NCI-H460 IC50
130.53 nM
Compound: SFG
Chemo-sensitizing activity against human NCI-H460 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 279.69 +/-31.94 nM)
Chemo-sensitizing activity against human NCI-H460 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 279.69 +/-31.94 nM)
[PMID: 34496204]
NCI-H460 IC50
172.9 nM
Compound: SFG
Chemo-sensitizing activity against human NCI-H460 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 279.69 +/-31.94 nM)
Chemo-sensitizing activity against human NCI-H460 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 279.69 +/-31.94 nM)
[PMID: 34496204]
NCI-H460 IC50
22.12 μM
Compound: SFG
Cytotoxicity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
[PMID: 34496204]
NCI-H460 IC50
29.32 μM
Compound: SFG
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
[PMID: 34496204]
NCI-H460 IC50
358.5 nM
Compound: SFG
Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 963.32 +/-120.89 nM)
Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 963.32 +/-120.89 nM)
[PMID: 34496204]
NCI-H460 IC50
419.28 nM
Compound: SFG
Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460MX20 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 3262.6 +/-811.81 nM)
Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460MX20 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 3262.6 +/-811.81 nM)
[PMID: 34496204]
NCI-H460 IC50
45.02 nM
Compound: SFG
Chemo-sensitizing activity against human NCI-H460 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 128.27 +/-22.6 nM)
Chemo-sensitizing activity against human NCI-H460 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 128.27 +/-22.6 nM)
[PMID: 34496204]
NCI-H460 IC50
451.72 nM
Compound: SFG
Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 3262.6 +/-811.81 nM)
Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 3262.6 +/-811.81 nM)
[PMID: 34496204]
NCI-H460 IC50
506.03 nM
Compound: SFG
Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 963.32 +/-120.89 nM)
Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 963.32 +/-120.89 nM)
[PMID: 34496204]
NCI-H460 IC50
76.5 nM
Compound: SFG
Chemo-sensitizing activity against human NCI-H460 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 128.27 +/-22.6 nM)
Chemo-sensitizing activity against human NCI-H460 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 128.27 +/-22.6 nM)
[PMID: 34496204]
NCI-H460 IC50
8.8 nM
Compound: SFG
Chemo-sensitizing activity against human NCI-H460 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 20.7 +/-6.32 nM)
Chemo-sensitizing activity against human NCI-H460 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 20.7 +/-6.32 nM)
[PMID: 34496204]
NCI-H460 IC50
801.14 nM
Compound: SFG
Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 3262.6 +/-811.81 nM)
Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 3262.6 +/-811.81 nM)
[PMID: 34496204]
NCI-H460 IC50
9.02 nM
Compound: SFG
Chemo-sensitizing activity against human NCI-H460 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 20.7 +/-6.32 nM)
Chemo-sensitizing activity against human NCI-H460 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 20.7 +/-6.32 nM)
[PMID: 34496204]
NCI-H460 IC50
9.4 nM
Compound: SFG
Chemo-sensitizing activity against human NCI-H460 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 20.7 +/-6.32 nM)
Chemo-sensitizing activity against human NCI-H460 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 20.7 +/-6.32 nM)
[PMID: 34496204]
NCI-H460 IC50
93.49 nM
Compound: SFG
Chemo-sensitizing activity against human NCI-H460 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 279.69 +/-31.94 nM)
Chemo-sensitizing activity against human NCI-H460 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 279.69 +/-31.94 nM)
[PMID: 34496204]
OVCAR-8 IC50
2.4 nM
Compound: SFG
Chemo-sensitizing activity against human OVCAR-8 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.62 +/-0.31 nM)
Chemo-sensitizing activity against human OVCAR-8 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.62 +/-0.31 nM)
[PMID: 34496204]
OVCAR-8 IC50
2.51 nM
Compound: SFG
Chemo-sensitizing activity against human OVCAR-8 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.62 +/-0.31 nM)
Chemo-sensitizing activity against human OVCAR-8 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.62 +/-0.31 nM)
[PMID: 34496204]
OVCAR-8 IC50
25.93 nM
Compound: SFG
Chemo-sensitizing activity against human OVCAR-8 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 28.73 +/-10.04 nM)
Chemo-sensitizing activity against human OVCAR-8 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 28.73 +/-10.04 nM)
[PMID: 34496204]
OVCAR-8 IC50
28.25 nM
Compound: SFG
Chemo-sensitizing activity against human OVCAR-8 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 28.73 +/-10.04 nM)
Chemo-sensitizing activity against human OVCAR-8 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 28.73 +/-10.04 nM)
[PMID: 34496204]
OVCAR-8 IC50
3.09 nM
Compound: SFG
Chemo-sensitizing activity against human OVCAR-8 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.62 +/-0.31 nM)
Chemo-sensitizing activity against human OVCAR-8 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.62 +/-0.31 nM)
[PMID: 34496204]
OVCAR-8 IC50
3.45 nM
Compound: SFG
Chemo-sensitizing activity against human OVCAR-8 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 6.01 +/-0.77 nM)
Chemo-sensitizing activity against human OVCAR-8 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 6.01 +/-0.77 nM)
[PMID: 34496204]
OVCAR-8 IC50
30.24 nM
Compound: SFG
Chemo-sensitizing activity against human OVCAR-8 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 28.73 +/-10.04 nM)
Chemo-sensitizing activity against human OVCAR-8 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 28.73 +/-10.04 nM)
[PMID: 34496204]
OVCAR-8 IC50
5.73 nM
Compound: SFG
Chemo-sensitizing activity against human OVCAR-8 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 6.01 +/-0.77 nM)
Chemo-sensitizing activity against human OVCAR-8 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 6.01 +/-0.77 nM)
[PMID: 34496204]
OVCAR-8 IC50
6 nM
Compound: SFG
Chemo-sensitizing activity against human OVCAR-8 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 6.01 +/-0.77 nM)
Chemo-sensitizing activity against human OVCAR-8 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 6.01 +/-0.77 nM)
[PMID: 34496204]
RAW264.7 IC50
10.9 μM
Compound: 9
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess method
[PMID: 26073007]
体外研究
(In Vitro)

Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cells?in a dose-dependent manner[1].
Sophoraflavanone G (0 -100 μM; 24 hours) induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochrome?c from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated "intrinsic" pathway[1]
Sophoraflavanone G (0 -40 μM; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner, with an IC50 value of 29.7 ± 5.2 μM[2]<.br>

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sophoraflavanone G 相关抗体:
分子量

424.49

Formula

C25H28O6
CAS 号
性状

固体

颜色

Off-white to light yellow

中文名称

苦参总黄酮； 苦参酚 F
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 250 mg/mL (588.94 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3558 mL 11.7788 mL 23.5577 mL
5 mM 0.4712 mL 2.3558 mL 4.7115 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

请根据您的 实验动物和给药方式 选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 方案 一

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (4.90 mM); 澄清溶液

    此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液 中，混合均匀。

    2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
  • 方案 二

    请依序添加每种溶剂： 10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (4.90 mM); 澄清溶液

    此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
请输入您的动物体内配方组成：
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。
方案所需 助溶剂 包括：DMSO， ，均可在 MCE 网站选购。 ，Tween 80，均可在 MCE 网站选购。
计算结果
工作液所需浓度 : mg/mL
储备液配制方法 : mg 药物溶于 μL  DMSO（母液浓度为 mg/mL）。
您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。
动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。
连续给药周期超过半月以上，请谨慎选择该方案。
请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热 （超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。
纯度 & 产品资料

纯度: 99.52%

COA (288 KB) LCMS (265 KB)

产品使用指南 (1538 KB)
参考文献

Sophoraflavanone G 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3558 mL 11.7788 mL 23.5577 mL 58.8942 mL
5 mM 0.4712 mL 2.3558 mL 4.7115 mL 11.7788 mL
10 mM 0.2356 mL 1.1779 mL 2.3558 mL 5.8894 mL
15 mM 0.1571 mL 0.7853 mL 1.5705 mL 3.9263 mL
20 mM 0.1178 mL 0.5889 mL 1.1779 mL 2.9447 mL
25 mM 0.0942 mL 0.4712 mL 0.9423 mL 2.3558 mL
30 mM 0.0785 mL 0.3926 mL 0.7853 mL 1.9631 mL
40 mM 0.0589 mL 0.2945 mL 0.5889 mL 1.4724 mL
50 mM 0.0471 mL 0.2356 mL 0.4712 mL 1.1779 mL
60 mM 0.0393 mL 0.1963 mL 0.3926 mL 0.9816 mL
80 mM 0.0294 mL 0.1472 mL 0.2945 mL 0.7362 mL
100 mM 0.0236 mL 0.1178 mL 0.2356 mL 0.5889 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sophoraflavanone G97938-30-2Kushenol F苦参总黄酮 苦参酚 FApoptosisMDA-MB-231HL60apoptosisanti-infammatoryInhibitorinhibitorinhibit

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