2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Apoptosis
  4. STAT3-IN-12

STAT3-IN-12 是一种有效的 STAT3 信号抑制剂，可以抑制 IL-6 诱导的 JAK/STAT3 信号通路的激活。STAT3-IN-12 可抑制癌细胞生长、迁移，并诱导细胞凋亡 (apoptosis) 以及周期阻滞。STAT3-IN-12 可用于癌症相关研究，如肝细胞癌 (HCC) 和食管癌。

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STAT3-IN-12 Chemical Structure

STAT3-IN-12 Chemical Structure

CAS No. : 2980758-31-2

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规格 价格 是否有货 数量
1 mg ￥681
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5 mg ￥1500
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10 mg ￥2500
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25 mg ￥5500
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Customer Review

STAT3-IN-12 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STAT3-IN-12 is a potent STAT3 signal inhibitor that can inhibit IL-6 induced JAK/STAT3 signalling pathway activation. STAT3-IN-12 inhibits cancer cell growth, migration, and induce cell apoptosis as well as cycle arrest. STAT3-IN-12 can be used in cancer-related research, such as hepatocellular carcinoma (HCC) and oesophageal carcinoma[1].

IC50 & Target[1]

STAT3

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
ECa-109 cell line IC50
3.63 μM
Compound: 24
Antitumor activity against human EC109 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antitumor activity against human EC109 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 35504209]
HepG2 IC50
4.3 μM
Compound: 24
Antitumor activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antitumor activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 35504209]
体外研究
(In Vitro)

STAT3-IN-12 (compound 24, 0-10 μM approximately, 72 h) inhibits cancer cell growth and migration in HepG2 and EC109 cells[1].
STAT3-IN-12 (0-20 μM, 16 h) binds to the STAT3 protein and inhibits IL-6-mediated STAT3 phosphorylation, also inhibts STAT3 nuclear localization and dimerization in EC109 and HepG2 cells[1].
STAT3-IN-12 (0-20 μM, 48 h) induces cell apoptosis as well as cycle arrest in HepG2 and EC109 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

STAT3-IN-12 相关抗体:

Cell Viability Assay[1]

Cell Line: HepG2 and EC109 cells
Concentration: 0, 1.25, 2.5, 5 and 10 μM.
Incubation Time: 72 h
Result: Inhibited cancer cell growth with IC50 values of 4.32 and 3.63 μM.

Cell Migration Assay [1]

Cell Line: HepG2 and EC109 cells
Concentration: 0-10 μM
Incubation Time: 24 h
Result: Inhibited cancer cell migration.

Western Blot Analysis[1]

Cell Line: HepG2 and EC109 cells
Concentration: 0, 2.5, 5, 10 and 20 μM
Incubation Time: 16 h
Result: Inhibited phosphorylation of STAT3 tyrosine 705 with high selectivity.
体内研究
(In Vivo)

STAT3-IN-12 (compound 24, intraperitoneal injection, 20, 40 mg/kg, daily for 24 days) displays obvious antitumor activity in a mouse HepG2 cell xenograft tumor model without no obvious toxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HepG2 cell xenograft tumor model[1]
Dosage: 20, 40 mg/kg, daily for 24 days
Administration: Intraperitoneal injection
Result: Inhibited tumor growth without affecting the body weight.
分子量

454.56

Formula

C28H30N4O2
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (219.99 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1999 mL 10.9996 mL 21.9993 mL
5 mM 0.4400 mL 2.1999 mL 4.3999 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

STAT3-IN-12 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1999 mL 10.9996 mL 21.9993 mL 54.9982 mL
5 mM 0.4400 mL 2.1999 mL 4.3999 mL 10.9996 mL
10 mM 0.2200 mL 1.1000 mL 2.1999 mL 5.4998 mL
15 mM 0.1467 mL 0.7333 mL 1.4666 mL 3.6665 mL
20 mM 0.1100 mL 0.5500 mL 1.1000 mL 2.7499 mL
25 mM 0.0880 mL 0.4400 mL 0.8800 mL 2.1999 mL
30 mM 0.0733 mL 0.3667 mL 0.7333 mL 1.8333 mL
40 mM 0.0550 mL 0.2750 mL 0.5500 mL 1.3750 mL
50 mM 0.0440 mL 0.2200 mL 0.4400 mL 1.1000 mL
60 mM 0.0367 mL 0.1833 mL 0.3667 mL 0.9166 mL
80 mM 0.0275 mL 0.1375 mL 0.2750 mL 0.6875 mL
100 mM 0.0220 mL 0.1100 mL 0.2200 mL 0.5500 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT3-IN-122980758-31-2STATApoptosisBenzobis derivativesapoptosis HepG2EC109xenograft tumor modelanticancerInhibitorinhibitorinhibit

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