2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Apoptosis
  4. STAT3-IN-3

STAT3-IN-3 是一种有效和选择性的 STAT3 抑制剂，有抗增殖活性。STAT3-IN-3 可以引起乳腺癌细胞凋亡 (apoptosis)。STAT3-IN-3 是有前途的靶向线粒体的 STAT3 抑制剂，能用于癌症的研究。

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STAT3-IN-3 Chemical Structure

STAT3-IN-3 Chemical Structure

CAS No. : 2361304-26-7

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规格 价格 是否有货 数量
1 mg ￥1590
In-stock
5 mg ￥3500
In-stock
10 mg ￥5500
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Customer Review

STAT3-IN-3 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3), with anti-proliferative activity. STAT3-IN-3 induces apoptosis in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research[1].

IC50 & Target[1]

STAT3

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
1.89 μM
Compound: 7a
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 31048139]
HepG2 IC50
2.88 μM
Compound: 7a
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 31048139]
L02 IC50
35.6 μM
Compound: 7a
Cytotoxicity against human LO2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human LO2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 31048139]
MCF-10A IC50
14.62 μM
Compound: 7a
Cytotoxicity against human MCF10A cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human MCF10A cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 31048139]
MCF7 IC50
3.33 μM
Compound: 7a
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 31048139]
MDA-MB-231 IC50
1.43 μM
Compound: 7a
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 31048139]
体外研究
(In Vitro)

STAT3-IN-3 对STAT1、JAK2、Src和Erk1/2的磷酸化水平没有影响[1]。
STAT3-IN-3 抑制 MDA-MB-231、HCT-116、HepG2 和 MCF-7 细胞的生长，IC50 分别为 1.43 μM、1.89 μM、2.88 μM 和 3.33 μM[1]。
STAT3-IN-3 下调 STAT3 靶基因 Bcl-2 和 Cyclin D1的表达[1]。
STAT3-IN-3 抑制 STAT3 酪氨酸磷酸化和丝氨酸磷酸化磷酸化[1]。
STAT3-IN-3 抑制 STAT3 DNA 结合活性[1]。
STAT3-IN-3 (1- 4 μM；24 小时) 增加 ROS 产生并显著降低线粒体膜电位，从而诱导线粒体凋亡途径[1]。
STAT3-IN-3 (1-4 μM；24 小时) 可诱导 caspase-9、caspase-3 和 PARP 的裂解[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

STAT3-IN-3 相关抗体:

Cell Viability Assay[1]

Cell Line: MDA-MB-231 cells, HCT-116 cells, HepG2 cells, MCF-7cells
Concentration: MTT assay
Incubation Time: 48 hours
Result: Exhibited anti-proliferative activity.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0 μM, 1 μM, 2 μM, 4 μM
Incubation Time: 24 hours
Result: Induced the apoptosis of MDA-MB-231 cells dose-dependently and the apoptosis rates.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0 μM, 1 μM, 2 μM, 4 μM
Incubation Time: 24 hours
Result: Induced the cleavage of caspase-9, caspase-3 and PARP.
体内研究
(In Vivo)

STAT3-IN-3 (10mg/kg -20mg/kg；腹腔注射；每日一次；持续 14 天) 对植入的 4T1 乳腺肿瘤生长具有有效的抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult female BALB/c mice (6 weeks of age)[1]
Dosage: 10 mg/kg, 20 mg/kg
Administration: Intraperitoneal injection, daily, for 14 days
Result: Significantly inhibited tumor volume.
分子量

600.48

Formula

C27H26BrN3O6S
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 5 mg/mL (8.33 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6653 mL 8.3267 mL 16.6533 mL
5 mM 0.3331 mL 1.6653 mL 3.3307 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

STAT3-IN-3 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6653 mL 8.3267 mL 16.6533 mL 41.6334 mL
5 mM 0.3331 mL 1.6653 mL 3.3307 mL 8.3267 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT3-IN-32361304-26-7STATApoptosisSTAT3mitochondria-targetingantitumormitochondrialapoptosispathwayInhibitorinhibitorinhibit

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目录号：
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