2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Apoptosis
  4. 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea 

目录号: HY-136658 纯度: 98.02%
COA 产品使用指南

摩尔计算器

STAT3-IN-7 是一种 Sorafenib 的衍生物，可有效抑制 STAT3 的磷酸化。STAT3-IN-7 通过依赖 SHP-1 的 STAT3 失活诱导细胞凋亡 (apoptosis)，不抑制激酶活性，并具有抗癌作用。

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1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea Chemical Structure

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea Chemical Structure

CAS No. : 1313019-65-6

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规格 价格 是否有货 数量
1 mg ￥1530
In-stock
5 mg ￥2970
In-stock
10 mg ￥4680
In-stock
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100 mg   询价  

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Customer Review

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STAT3-IN-7 is a Sorafenib analogue and potently inhibits the phosphorylation of STAT3. STAT3-IN-7 induces cell apoptosis through SHP-1 dependent STAT3 inactivation. STAT3-IN-7 does not inhibit kinase activity and has anticancer effects[1].

IC50 & Target[1]

p-STAT3

 

体外研究
(In Vitro)

STAT3-IN-7 (SC-1; 1-10 μM; 48 hours; breast cancer cells) treatment demonstrates dose-dependent suppression of cell viability in all tested breast cancer cells[1].
STAT3-IN-7 (SC-1; 1-10 μM; 36 hours; breast cancer cells) treatment induces potent apoptotic activity[1].
STAT3-IN-7 (SC-1; 1-10 μM; 36 hours; breast cancer cells) treatment shows downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea 相关抗体:

Cell Viability Assay[1]

Cell Line: HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells
Concentration: 1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM
Incubation Time: 48 hours
Result: Demonstrated dose-dependent suppression of cell viability in all tested breast cancer cells.

Apoptosis Analysis[1]

Cell Line: HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells
Concentration: 1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM
Incubation Time: 36 hours
Result: Induced potent apoptotic activity.

Western Blot Analysis[1]

Cell Line: HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells
Concentration: 1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM
Incubation Time: 36 hours
Result: Showed downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines.
体内研究
(In Vivo)

STAT3-IN-7 (10 mg/kg; oral gavage; daily; for 28 days; female NCr athymic nude mice) treatment shows efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NCr athymic nude mice (4-6 weeks of age) injected with breast cancer cells [1]
Dosage: 10 mg/kg
Administration: Oral gavage; daily; for 28 days
Result: Showed efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors.
分子量

431.80

Formula

C21H13ClF3N3O2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 250 mg/mL (578.97 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3159 mL 11.5794 mL 23.1589 mL
5 mM 0.4632 mL 2.3159 mL 4.6318 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3159 mL 11.5794 mL 23.1589 mL 57.8972 mL
5 mM 0.4632 mL 2.3159 mL 4.6318 mL 11.5794 mL
10 mM 0.2316 mL 1.1579 mL 2.3159 mL 5.7897 mL
15 mM 0.1544 mL 0.7720 mL 1.5439 mL 3.8598 mL
20 mM 0.1158 mL 0.5790 mL 1.1579 mL 2.8949 mL
25 mM 0.0926 mL 0.4632 mL 0.9264 mL 2.3159 mL
30 mM 0.0772 mL 0.3860 mL 0.7720 mL 1.9299 mL
40 mM 0.0579 mL 0.2895 mL 0.5790 mL 1.4474 mL
50 mM 0.0463 mL 0.2316 mL 0.4632 mL 1.1579 mL
60 mM 0.0386 mL 0.1930 mL 0.3860 mL 0.9650 mL
80 mM 0.0289 mL 0.1447 mL 0.2895 mL 0.7237 mL
100 mM 0.0232 mL 0.1158 mL 0.2316 mL 0.5790 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea1313019-65-6STATApoptosisSHP-1p-STAT3anticancercyclin-D1survivinorallykinaseInhibitorinhibitorinhibit

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