2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation Anti-infection
  3. Dopamine Receptor Histamine Receptor Bacterial Amyloid-β
  4. Thiethylperazine dimaleate

Thiethylperazine dimaleate  (Synonyms: 二马来酸硫乙基哌嗪)

目录号: HY-B1794A 纯度: 99.72%
COA 产品使用指南

摩尔计算器

Thiethylperazine dimaleate 是一种吩噻嗪衍生物，是一种口服有效的多巴胺 D2 受体和组胺 H1 受体拮抗剂。Thiethylperazine dimaleate 也是一种选择性的 ABCC1 激活剂，可减少小鼠中的淀粉样 β (Aβ) 负荷。Thiethylperazine dimaleate 具有止吐，抗精神病和抗菌作用。

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Thiethylperazine dimaleate Chemical Structure

Thiethylperazine dimaleate Chemical Structure

CAS No. : 1179-69-7

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10 mg ￥1500
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50 mg ￥4500
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500 mg   询价  

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Customer Review

Other Forms of Thiethylperazine dimaleate:

Thiethylperazine dimaleate 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Dopamine Receptor 亚型特异性产品:

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Thiethylperazine dimaleate, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine dimaleate is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine dimaleate has anti-emetic, antipsychotic and antimicrobial effects[1][2][3].

IC50 & Target

D2 Receptor

 

H1 Receptor

 

体外研究
(In Vitro)

Thiethylperazine could enhance the antibiotic (Vancomycin) activity at a concentration as low as 2 μg/mL. Thiethylperazine inhibits Vancomycin-sensitive E. faecalis ATCC 29212, Vancomycin-resistant E. faecalis ATCC 51299 and vancomycin-resistant E. faecalis (VREF) isolates with MIC values of 8 μg/mL, 16 μg/mL and 8 μg/mL, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Thiethylperazine dimaleate 相关抗体:
体内研究
(In Vivo)

Thiethylperazine (3 mg/kg; intramuscular injection; twice daily; for 30 days; young APP/PS1 mice) treatment significantly reduces Aβ42 levels in APP/PS1 mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Young Aβ precursor protein (APPswe) and mutant presenilin-1 (PS1) (APP/PS1) mice[2]
Dosage: 3 mg/kg
Administration: Intramuscular injection; twice daily; for 30 days
Result: Significantly reduced Aβ42 levels in APP/PS1 mice.
分子量

631.76

Formula

C30H37N3O8S2
CAS 号
性状

固体

颜色

White to off-white

中文名称

二马来酸硫乙基哌嗪
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (197.86 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5829 mL 7.9144 mL 15.8288 mL
5 mM 0.3166 mL 1.5829 mL 3.1658 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Thiethylperazine dimaleate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5829 mL 7.9144 mL 15.8288 mL 39.5720 mL
5 mM 0.3166 mL 1.5829 mL 3.1658 mL 7.9144 mL
10 mM 0.1583 mL 0.7914 mL 1.5829 mL 3.9572 mL
15 mM 0.1055 mL 0.5276 mL 1.0553 mL 2.6381 mL
20 mM 0.0791 mL 0.3957 mL 0.7914 mL 1.9786 mL
25 mM 0.0633 mL 0.3166 mL 0.6332 mL 1.5829 mL
30 mM 0.0528 mL 0.2638 mL 0.5276 mL 1.3191 mL
40 mM 0.0396 mL 0.1979 mL 0.3957 mL 0.9893 mL
50 mM 0.0317 mL 0.1583 mL 0.3166 mL 0.7914 mL
60 mM 0.0264 mL 0.1319 mL 0.2638 mL 0.6595 mL
80 mM 0.0198 mL 0.0989 mL 0.1979 mL 0.4946 mL
100 mM 0.0158 mL 0.0791 mL 0.1583 mL 0.3957 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thiethylperazine dimaleate1179-69-7二马来酸硫乙基哌嗪Dopamine ReceptorHistamine ReceptorBacterialAmyloid-ββ-amyloid peptideAβAbetaAnti-emeticphenothiazineD2-receptorH1-receptorpregnancycleftAlzheimerdiseaseAβ42ABCC1antipsychoticInhibitorinhibitorinhibit

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目录号：
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