2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. Tienilic acid

Tienilic acid  (Synonyms: 替宁酸; Ticrynafen; ANP 3624)

目录号: HY-21065 纯度: 99.85%
COA 产品使用指南

摩尔计算器

Tienilic acid (Ticrynafen; ANP 3624) 可作为利尿剂降血压剂。然而，Tienilic acid 会引起肝毒性。Tienilic acid 在体外通过细胞色素 P450 (CYP) 转化为亲电子代谢物。

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Tienilic acid Chemical Structure

Tienilic acid Chemical Structure

CAS No. : 40180-04-9

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥360
In-stock
5 mg ￥328
In-stock
10 mg ￥566
In-stock
25 mg ￥1159
In-stock
50 mg ￥1738
In-stock
100 mg ￥2613
In-stock
200 mg ￥3938
In-stock
500 mg   询价  
1 g   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Tienilic acid:

Tienilic acid 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tienilic acid (Ticrynafen; ANP 3624) acts as a diuretic hypotensive agent. However, Tienilic acid induces hepatotoxicity. Tienilic acid is converted into electrophilic metabolites by cytochrome P450 (CYP) in vitro[1].

体内研究
(In Vivo)

Tienilic acid (在大鼠和小鼠中为 100 mg/lg，在猪和狗中为 5 mg/kg；PO 和静脉注射；单剂量) 仅存在于血浆中，通过胆汁和尿液快速消除，并且在不同的物种[2]。
Tienilic acid (0-480 mg/kg；口服28 天) 降低血压、血清、尿酸血红蛋白，并增加 S-GPT；诱导小群肝细胞单细胞坏死[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats, mice, pigs and dogs[2]
Dosage: 100 mg/lg in rats and mice, 5 mg/kg in pigs and dogs
Administration: PO and IV; single dosage
Result: Only found in plasma with important bindings to the plasma proteins at the blood level; pharmacological action for several hours; eliminated by the biliary and particularly the urinary fast, practically total in the first 48 hours after administration; only small differences were observed for the parameters measured in the different species.
Animal Model: Female and male Sprague-Dawley rats[3]
Dosage: 0, 30, 120 and 480 mg/kg
Administration: PO; for 28 days
Result: Decreased blood pressure and serum uric acid at 30 mg/kg; decreased slightly hemoglobin and increased S-GPT at 120 and 480 mg/kg; significantly increase the liver weight and serum magnesium concentration in male rats, while the liver weight of female rats increased only slightly; besides, induced unicellular necrosis of small groups of liver cells.
分子量

331.18

Formula

C13H8Cl2O4S
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (301.95 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0195 mL 15.0977 mL 30.1954 mL
5 mM 0.6039 mL 3.0195 mL 6.0391 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.85%

COA (289 KB) HNMR (274 KB) LCMS (265 KB)

产品使用指南 (1538 KB)
参考文献

Tienilic acid 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0195 mL 15.0977 mL 30.1954 mL 75.4886 mL
5 mM 0.6039 mL 3.0195 mL 6.0391 mL 15.0977 mL
10 mM 0.3020 mL 1.5098 mL 3.0195 mL 7.5489 mL
15 mM 0.2013 mL 1.0065 mL 2.0130 mL 5.0326 mL
20 mM 0.1510 mL 0.7549 mL 1.5098 mL 3.7744 mL
25 mM 0.1208 mL 0.6039 mL 1.2078 mL 3.0195 mL
30 mM 0.1007 mL 0.5033 mL 1.0065 mL 2.5163 mL
40 mM 0.0755 mL 0.3774 mL 0.7549 mL 1.8872 mL
50 mM 0.0604 mL 0.3020 mL 0.6039 mL 1.5098 mL
60 mM 0.0503 mL 0.2516 mL 0.5033 mL 1.2581 mL
80 mM 0.0377 mL 0.1887 mL 0.3774 mL 0.9436 mL
100 mM 0.0302 mL 0.1510 mL 0.3020 mL 0.7549 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tienilic acid40180-04-9Ticrynafen ANP 3624ANP3624ANP 3624ANP-3624Cytochrome P450CYPsdiuretic hypotensive agentinduces hepatotoxicityInhibitorinhibitorinhibit

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