2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Timolol

Timolol  (Synonyms: 噻吗洛尔; (S)-L-714,465; MK 950 free base)

目录号: HY-17494
产品使用指南 技术支持

Timolol 是一种 β 受体阻滞剂，可用于局部和全身给药。局部 Timolol 要用于降低开角型青光眼和高眼压。Timolol 还可用于婴儿血管瘤、高血压、心肌梗塞、偏头痛预防和心房颤动的研究。Timolol 还具有保护心脏的作用。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 (S)-Timolol maleate 通常具有更好的水溶性和稳定性。

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Timolol Chemical Structure

Timolol Chemical Structure

CAS No. : 26839-75-8

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Timolol 的其他形式现货产品:

Customer Review

Other Forms of Timolol:

Timolol 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Timolol is a β-blocker available for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect[1][2].

IC50 & Target

β adrenergic receptor

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-375 IC50
> 100 μM
Compound: Timolol
Antiproliferative activity against human A375 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human A375 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 32216987]
SK-MEL-28 IC50
> 100 μM
Compound: Timolol
Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 32216987]
SK-MEL-5 IC50
> 100 μM
Compound: Timolol
Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 32216987]
体外研究
(In Vitro)

Timolol can significantly prevent the increased lipid peroxidation level of the heart from diabetic rats. Timolol can induce a well-balanced ratio between oxidative stress and antioxidant defense system in the diabetic animals, can have an important cardioprotection against diabetes-induced ERS and associated apoptotic effects[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Timolol 相关抗体:
体内研究
(In Vivo)

Timolol has a cardioprotective effect via inhibition of ERS response in diabetic rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Experimental diabetes model: 3-month old male Wistar rats[3].
Dosage: 5 mg/kg
Administration: Timolol (5 mg/kg daily for 12-week)
Result: Showed cardioprotective effect.
Clinical Trial
分子量

316.42

Formula

C13H24N4O3S
CAS 号
中文名称

噻吗洛尔
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Timolol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Timolol26839-75-8(S)-L-714,465MK 950噻吗洛尔MK950MK-950Adrenergic ReceptorBeta Receptorβ-blockeropen-angle glaucomaocular hypertensioninfantile hemangiomashypertensionmyocardial infarctionmigraine prophylaxisatrial fibrillationInhibitorinhibitorinhibit

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