Triclabendazole-¹³C,d₃  (Synonyms: 三氯苯达唑-¹³C,d₃; CGA89317-¹³C,d₃)

Triclabendazole-¹³C,d₃ is the ¹³C- and deuterium labeled Triclabendazole[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[52].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

363.67

C₁₃¹³CH₆D₃Cl₃N₂OS

68786-66-3

三氯苯达唑-¹³C,d₃；三氯苯哒唑-¹³C,d₃；三氯苯咪唑-¹³C,d₃；三氯苯唑-¹³C,d₃

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.  [Content Brief]

  [2]. Moll, L., et al., Resistance of Fasciola hepatica against triclabendazole in cattle and sheep in The netherlands. Vet Parasitol, 2000. 91(1-2): p. 153-8.  [Content Brief]

  [3]. Robinson, M.W., et al., Triclabendazole-resistant Fasciola hepatica: beta-tubulin and response to in vitro treatment with triclabendazole. Parasitology, 2002. 124(Pt 3): p. 325-38.  [Content Brief]

  [4]. Fairweather, I., Triclabendazole: new skills to unravel an old(ish) enigma. J Helminthol, 2005. 79(3): p. 227-34.  [Content Brief]