1. NF-κB Apoptosis
  2. NF-κB TNF Receptor IKK
  3. Verproside

Verproside,一种从 Pseudolysimachion 属分离的梓醇衍生物环烯醚萜苷,通过 IKK/IκB 信号级联反应抑制 NF-κB 活化,抑制TNF-α 诱导的 MUC5AC 表达。Verproside具有有效的抗炎,抗氧化,抗伤害和抗哮喘作用,并且可用于慢性阻塞性肺疾病 (COPD) 的研究。

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Verproside Chemical Structure

Verproside Chemical Structure

CAS No. : 50932-20-2

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive and anti-asthmatic activities. Verproside has the potential for the study of chronic obstructive pulmonary disease (COPD)[1].

IC50 & Target[1]

NF-κB

 

IKK

 

体外研究
(In Vitro)

Verproside(2.5-20 μM;持续 2 小时)显着降低 5-20 μM 范围内 IKKα/β、IκBα 和 TAK1 的磷酸化水平[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: NCI-H292 cells
Concentration: 2.5, 5, 10, 20 μM
Incubation Time: 2 hours
Result: Resulted in markedly reduced phosphorylation levels of IKKα/β, IκBα, and TAK1.
体内研究
(In Vivo)

Verproside(胃内;30 mg/kg;48 小时)显着降低接受 verproside 治疗的小鼠的免疫球蛋白 E (IgE) 水平[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Specific pathogen-free female BALB/c mice aged 8-10 weeks[2]
Dosage: 30 mg/kg
Administration: Intragastrically; 48 hours
Result: Reduced significantly the immunoglobulin E (IgE) levels.
分子量

498.43

Formula

C22H26O13

CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Verproside
目录号:
HY-126232
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