Verproside 

Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive and anti-asthmatic activities. Verproside has the potential for the study of chronic obstructive pulmonary disease (COPD)^[1].

Verproside（2.5-20 μM；持续 2 小时）显着降低 5-20 μM 范围内 IKKα/β、IκBα 和 TAK1 的磷酸化水平^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Verproside（胃内；30 mg/kg；48 小时）显着降低接受 verproside 治疗的小鼠的免疫球蛋白 E (IgE) 水平^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

498.43

C₂₂H₂₆O₁₃

50932-20-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lee SU, et al. Verproside inhibits TNF-α-induced MUC5AC expression through suppression of the TNF-α/NF-κB pathway in human airway epithelial cells. Cytokine. 2016 Jan;77:168-75.  [Content Brief]

  [2]. Oh SR, et al. Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma. Int Immunopharmacol. 2006 Jun;6(6):978-86. Epub 2006 Feb 10.  [Content Brief]