Y-27632 hydrochloride hydrate

目录号: HY-10071A: FAQs
Data Sheet 产品使用指南技术支持

Y-27632 hydrochloride hydrate 是口服有效的，ATP 竞争性的 ROCK-I 和 ROCK-II 抑制剂，K_i 分别为 220 nM 和 300 nM。Y-27632 hydrochloride hydrate 减弱阿霉素诱导的人心脏干细胞凋亡 (apoptosis)。Y-27632 hydrochloride hydrate 还抑制分离诱导的小鼠前列腺干/祖细胞凋亡。Y-27632 hydrochloride hydrate 通过上皮-间充质过渡样调节引发人诱导多能干细胞 (hIPSCs) 选择性地分化为间胚层谱系。

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Y-27632 hydrochloride hydrate Chemical Structure

CAS No. : 331752-47-7

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Y-27632 hydrochloride hydrate 的其他形式现货产品:

Y-27632 Y-27632 dihydrochloride Y-27632 dihydrochloride (GMP) Y-27632 (dihydrochloride) (Standard)

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Other Forms of Y-27632 hydrochloride hydrate:

Y-27632 In-stock
Y-27632 dihydrochloride In-stock
Y-27632 dihydrochloride (GMP) In-stock
Y-27632 (dihydrochloride) (Standard) In-stock

MCE 顾客使用本产品发表的 322 篇科研文献

: Y-27632 hydrochloride hydrate purchased from MCE. Usage Cited in: Adv Sci (Weinh). 2020 Jun 17;7(15):1903583. [Abstract]; Immunofluorescence imaging of LNCaP cells treated with the Cytoskeleton B (CB), Nocodazole (NO), PF-573288 (PF), Y-27632 (Y), and (-)-Blebbistatin ((-) Bl). After the cells are cultured on different substrates for 3 days, inhibitors are added and incubated for 24 h.

: Y-27632 hydrochloride hydrate purchased from MCE. Usage Cited in: Adv Sci (Weinh). 2020 Jun 17;7(15):1903583. [Abstract]; Expression of CTC cluster-related (plakoglobin and CD44) and EMT-related (vimentin and E-cadherin, 4 days) proteins in LNCaP cells grown on different substrates after treatment with different inhibitors (Cytoskeleton B (CB), Nocodazole (NO), PF-573288 (PF), Y-27632 (Y), and (-)-Blebbistatin ((-) Bl)).

: Y-27632 hydrochloride hydrate purchased from MCE. Usage Cited in: J Exp Clin Cancer Res. 2018 Jun 28;37(1):128. [Abstract]; MHCC-97H and Huh-7 cells co-transfected with control or supervillin-specific siRNA and a RhoA(WT), RhoA(V14), or RhoA(N19) plasmids for 48 h are treated with PBS or Y27632 2HCl (10 μM) for 16 h during hypoxia, and then assayed for phosphorylated p38 and ERK by immunoblotting. β-actin is used as the loading control

: Y-27632 hydrochloride hydrate purchased from MCE. Usage Cited in: Oncotarget. 2017 Jul 31;8(47):82506-82530. [Abstract]; SKOV3 mock-transfected control (Ctrl) and shRNA-Hic-5 knockdown (KD) (sh-S1 and sh-S2) cells were either untreated (-) or treated (+) with 10mM Y27632 over a period of 48 hr. SKOV3 mock-transfected control (Ctrl) and shRNA-Hic-5 knockdown (KD) (sh-S1 and sh-S2) clones were either untreated (-) or treated (+) with 10 mM Y27632 followed by stimulation without (-) or with (+) 5 ng/mL of TGFβ1 for 48 hr.