2. Epigenetics Metabolic Enzyme/Protease
  3. Histone Demethylase Endogenous Metabolite
  4. α-Hydroxyglutaric acid disodium

α-Hydroxyglutaric acid disodium  (Synonyms: 2-Hydroxyglutarate disodium; 2-Hydroxyglutaric acid disodium; 2-Hydroxypentanedioic acid disodium)

目录号: HY-113038A 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium 是戊二酸的 α-羟基酸形式。α-Hydroxyglutaric acid disodium 是多种 α-酮戊二酸依赖性双加氧酶 (包括 histone demethylases 和 5-甲基胞嘧啶羟化酶 (5-methlycytosine (5mC) hydroxylases) 的 TET 家族) 的竞争性抑制剂。

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α-Hydroxyglutaric acid disodium Chemical Structure

α-Hydroxyglutaric acid disodium Chemical Structure

CAS No. : 40951-21-1

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规格 价格 是否有货 数量
1 mg ￥187
In-stock
5 mg ￥375
In-stock
10 mg ￥600
In-stock
25 mg ￥1100
In-stock
50 mg ￥1400
In-stock
100 mg ￥1700
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of α-Hydroxyglutaric acid disodium:

α-Hydroxyglutaric acid disodium 相关抗体

Top Publications Citing Use of Products

查看 Histone Demethylase 亚型特异性产品:

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KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Isocitrate Dehydrogenase 1 (IDH1) and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium, respectively[1].
α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium inhibits the activity of multiple histone demethylases. α-Hydroxyglutaric acid occupies the same space as α-KG does in the active site of histone demethylases. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium inhibits the activity of TET 5-methylcytosine hydroxylases[1].
Treatment of U-87MG cells with α-Hydroxyglutaric acid (2-Hydroxyglutarate; 10-50 mM) disodium increases HIF-1α and decreases endostatin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

α-Hydroxyglutaric acid disodium 相关抗体:
分子量

192.08

Formula

C5H6Na2O5
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 125 mg/mL (650.77 mM; 超声助溶 (<60°C))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.2062 mL 26.0308 mL 52.0616 mL
5 mM 1.0412 mL 5.2062 mL 10.4123 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

α-Hydroxyglutaric acid disodium 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.2062 mL 26.0308 mL 52.0616 mL 130.1541 mL
5 mM 1.0412 mL 5.2062 mL 10.4123 mL 26.0308 mL
10 mM 0.5206 mL 2.6031 mL 5.2062 mL 13.0154 mL
15 mM 0.3471 mL 1.7354 mL 3.4708 mL 8.6769 mL
20 mM 0.2603 mL 1.3015 mL 2.6031 mL 6.5077 mL
25 mM 0.2082 mL 1.0412 mL 2.0825 mL 5.2062 mL
30 mM 0.1735 mL 0.8677 mL 1.7354 mL 4.3385 mL
40 mM 0.1302 mL 0.6508 mL 1.3015 mL 3.2539 mL
50 mM 0.1041 mL 0.5206 mL 1.0412 mL 2.6031 mL
60 mM 0.0868 mL 0.4338 mL 0.8677 mL 2.1692 mL
80 mM 0.0651 mL 0.3254 mL 0.6508 mL 1.6269 mL
100 mM 0.0521 mL 0.2603 mL 0.5206 mL 1.3015 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Hydroxyglutaric acid disodium40951-21-12-Hydroxyglutarate disodium2-Hydroxyglutaric acid disodium2-Hydroxypentanedioic acid disodiumHistone DemethylaseEndogenous MetaboliteCell-permeable5-methylcytosineα-ketoglutaratedioxygenasesIDH1IDH2Inhibitorinhibitorinhibit

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