2. Anti-infection NF-κB Cell Cycle/DNA Damage PI3K/Akt/mTOR Autophagy Apoptosis
  3. Bacterial Antibiotic NF-κB PERK Akt Autophagy Apoptosis
  4. Bavachalcone

Bavachalcone  (Synonyms: 补骨脂查耳酮; Broussochalcone B)

目录号: HY-N0231 纯度: 99.95%
COA 产品使用指南

摩尔计算器

Bavachalcone 是有效的凋亡 (apoptosis) 诱导剂。Bavachalcone 通过促进 HepG2 细胞的自噬 (autophagy) 和凋亡发挥抗癌活性。Bavachalcone 通过 NF-κB 通路发挥抗神经炎症和抗抑郁的作用。Bavachalcone 通过干扰 ERK 和 Akt 信号通路以及 c-Fos 和 NFATc1 的表达抑制破骨细胞的发生。Bavachalcone 在体外对杆状病毒表达的 BACE-1 有显著的抑制作用。

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Bavachalcone Chemical Structure

Bavachalcone Chemical Structure

CAS No. : 28448-85-3

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规格 价格 是否有货 数量
1 mg ￥650
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5 mg ￥1600
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10 mg ￥2480
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100 mg   询价  

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Customer Review

Other Forms of Bavachalcone:

Bavachalcone 相关抗体

Top Publications Citing Use of Products

查看 Antibiotic 亚型特异性产品:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bavachalcone is a potent inducer of apoptosis. Bavachalcone exerts anticancer activity by promoting autophagy and apoptosis in HepG2 cells. Bavachalcone acts as an anti-neuroinflammatory and antidepressant through the NF-κB pathway. Bavachalcone inhibits osteoclasts by interfering with ERK and Akt signaling pathways and the expression of c-Fos and NFATc1. Bavachalcone exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro[1][2][3][4].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 10 μM
Compound: 9
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 25710081]
HUVEC IC50
39.73 μM
Compound: 1a
Toxicity against HUVEC incubated for 48 hrs by MTT assay
Toxicity against HUVEC incubated for 48 hrs by MTT assay
[PMID: 25590864]
K562 IC50
> 10 μM
Compound: 9
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
[PMID: 25710081]
K562 IC50
2.77 μM
Compound: 1a
Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay
Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay
[PMID: 25590864]
体外研究
(In Vitro)

Bavachalcone (5 μg/mL; 1-48 小时) 通过干扰 ERK 和 Akt 信号通路以及 c-Fos 和 NFATc1 的表达抑制破骨细胞的发生[1]。
Bavachalcone (0-100 μg/mL; 24 小时) 对 HepG2 细胞有毒性， IC50 为 20 μg/mL[3]。
Bavachalcone (20 μg/mL; 24 小时) 在 HepG2 中可诱导细胞凋亡[3]。
Bavachalcone (0-20 μg/mL; 24 小时) 在 HepG2 细胞中引起细胞周期阻滞[3]。
Bavachalcone (0-20 μg/mL; 24 小时) 通过 Akt-mTOR 信号通路诱导细胞自噬[3]。
Bavachalcone (5-10 μM; 2 小时) 在 LPS (HY-D1056) 诱导的 BV2 细胞中抑制 NF-κB 通路活化，上调 A20 和 TAX1BP1 的表达并增强其相互作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bavachalcone 相关抗体:

Western Blot Analysis[1]

Cell Line: RANKL treated bone marrow-derived macrophages
Concentration: 5 μg/mL
Incubation Time: 0, 12, 24 and 48 h;
1 h
Result: Reduced the levels of c-Fos and NFATc1.
Reduced the phosphorylation levels of ERK and Akt.

Western Blot Analysis[3]

Cell Line: HepG2 cell
Concentration: 20 μg/mL
Incubation Time: 24 h
Result: Significantly increased the levels of caspase-3.

Western Blot Analysis[3]

Cell Line: HepG2 cell
Concentration: 0, 5, 10 and 20 μg/mL
Incubation Time: 24 h
Result: Decreased the levels of early cell cycle regulatory proteins cdk4 and cdk2.
Increased the levels of p21 and p27.
Inhibited the phosphorylation and expression of both Akt and mTOR.

Western Blot Analysis[4]

Cell Line: LPS (HY-D1056) treated BV2 cells
Concentration: 5 μM and 10 μM
Incubation Time: 2 h
Result: Significantly decreased the expression of TRAF6 and phosphorylation of P65 and IκBα.
Increased the expression of A20 and TAX1BP1
体内研究
(In Vivo)

Bavachalcone (30-60 mg/kg; 腹腔注射; 4 天) 在脂多糖 (HY-D1056) 诱导的小鼠模型中发挥抗神经炎症和抗抑郁的作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS (HY-D1056) treated male C57BL/6 mice (8 weeks, 20 ± 2 g)
Dosage: 30 mg/kg and 60 mg/kg
Administration: Intraperitoneal injection (i.p.); 4 days
Result: Attenuated LPS-induced depression-like behaviors in mice.
Inhibited LPS-induced activation of microglia in the brain of mice.
Inhibited LPS-induced NF-κB pathway activation and upregulated the expression of A20 and TAX1BP1 in the cortex of mice.
Weakened the production of TNF-α and IL-6 in the cortex of mice.
分子量

324.37

Formula

C20H20O4
CAS 号
性状

固体

颜色

Yellow to orange

中文名称

补骨脂查耳酮
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 34 mg/mL (104.82 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0829 mL 15.4145 mL 30.8290 mL
5 mM 0.6166 mL 3.0829 mL 6.1658 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.95%

COA (282 KB) HNMR (173 KB) RP-HPLC (332 KB)

产品使用指南 (1538 KB)
参考文献

Bavachalcone 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0829 mL 15.4145 mL 30.8290 mL 77.0725 mL
5 mM 0.6166 mL 3.0829 mL 6.1658 mL 15.4145 mL
10 mM 0.3083 mL 1.5414 mL 3.0829 mL 7.7072 mL
15 mM 0.2055 mL 1.0276 mL 2.0553 mL 5.1382 mL
20 mM 0.1541 mL 0.7707 mL 1.5414 mL 3.8536 mL
25 mM 0.1233 mL 0.6166 mL 1.2332 mL 3.0829 mL
30 mM 0.1028 mL 0.5138 mL 1.0276 mL 2.5691 mL
40 mM 0.0771 mL 0.3854 mL 0.7707 mL 1.9268 mL
50 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.5414 mL
60 mM 0.0514 mL 0.2569 mL 0.5138 mL 1.2845 mL
80 mM 0.0385 mL 0.1927 mL 0.3854 mL 0.9634 mL
100 mM 0.0308 mL 0.1541 mL 0.3083 mL 0.7707 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bavachalcone28448-85-3Broussochalcone B补骨脂查耳酮BacterialAntibioticNF-κBPERKAktAutophagyApoptosisNuclear factor-κBNuclear factor-kappaBProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinasePKBProtein kinase BHepG2 cellsOsteoclastogenesis Anticancer agentAnti-depressionInhibitorinhibitorinhibit

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