2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Flavin adenine dinucleotide

Flavin adenine dinucleotide  (Synonyms: 黄素腺嘌呤二核苷酸; FAD)

目录号: HY-B1654 纯度: 99.13%
COA 产品使用指南

摩尔计算器

Flavin adenine dinucleotide (FAD) 是一种氧化还原辅因子，蛋白质的辅基，在代谢过程中参与了几个重要的酶反应。

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Flavin adenine dinucleotide Chemical Structure

Flavin adenine dinucleotide Chemical Structure

CAS No. : 146-14-5

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Other Forms of Flavin adenine dinucleotide:

Flavin adenine dinucleotide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Poly(Flavin adenine dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10-3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Flavin adenine dinucleotide 相关抗体:
体内研究
(In Vivo)

Flavin adenine dinucleotide (2 mg/kg, i.v.) significantly cancels chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT). Flavin adenine dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin adenine dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin adenine dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

785.55

Formula

C27H33N9O15P2
CAS 号
性状

固体

颜色

Yellow to orange

中文名称

黄素腺嘌呤二核苷酸
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 125 mg/mL (159.12 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2730 mL 6.3650 mL 12.7299 mL
5 mM 0.2546 mL 1.2730 mL 2.5460 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.13%

COA (201 KB) HNMR (295 KB) RP-HPLC (242 KB)

产品使用指南 (1538 KB)
参考文献
Animal Administration
[1]

Dogs[1]
The dogs are divided into 3 groups and they are received the following treatments. Each group consists of 6 dogs. Dogs in group I as control, are given 2 mL/kg of physiological saline by intravenous injection. Ten min after the start of the first injection, another dose of saline, 1 mL/kg, is injected intravenously. Dogs in group II are given i.v. 2 mL saline/kg. Ten min afterwards, 1 mg chlorpromazine(CPZ)/kg is injected. Dogs in group III are given i.v. Flavin Adenin Dinucleotide, 2 mg/kg. Ten min later, they are given CPZ, 1 mg/kg. All solutions is administrated in 1 min or 2. Blood samples are taken before and 10, 20, 30, and 40 min after the intravenous injection of saline (groups I and II) or Flavin Adenin Dinucleotide (group III). Serum K+ and blood pH are also measured. Heart rate, blood pressure and ventricular fibrillation threshold (VFT) of each dog are recorded at the same intervals[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Flavin adenine dinucleotide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.2730 mL 6.3650 mL 12.7299 mL 31.8248 mL
5 mM 0.2546 mL 1.2730 mL 2.5460 mL 6.3650 mL
10 mM 0.1273 mL 0.6365 mL 1.2730 mL 3.1825 mL
15 mM 0.0849 mL 0.4243 mL 0.8487 mL 2.1217 mL
20 mM 0.0636 mL 0.3182 mL 0.6365 mL 1.5912 mL
25 mM 0.0509 mL 0.2546 mL 0.5092 mL 1.2730 mL
30 mM 0.0424 mL 0.2122 mL 0.4243 mL 1.0608 mL
40 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.7956 mL
50 mM 0.0255 mL 0.1273 mL 0.2546 mL 0.6365 mL
60 mM 0.0212 mL 0.1061 mL 0.2122 mL 0.5304 mL
80 mM 0.0159 mL 0.0796 mL 0.1591 mL 0.3978 mL
100 mM 0.0127 mL 0.0636 mL 0.1273 mL 0.3182 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flavin adenine dinucleotide146-14-5FAD黄素腺嘌呤二核苷酸Endogenous MetaboliteInhibitorinhibitorinhibit

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