2. Autophagy Anti-infection
  3. Autophagy Parasite
  4. Lucanthone

Lucanthone  (Synonyms: 硫蒽酮)

目录号: HY-B2098 纯度: 99.75%
COA 产品使用指南

摩尔计算器

Lucanthone 是 Apurinic 内切核酸酶-1 (APE-1) 的内切核酸酶抑制剂。

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Lucanthone Chemical Structure

Lucanthone Chemical Structure

CAS No. : 479-50-5

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1408
In-stock
1 mg ￥520
In-stock
5 mg ￥1280
In-stock
10 mg ￥2040
In-stock
25 mg ￥4080
In-stock
50 mg 现货 询价
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Other Forms of Lucanthone:

Lucanthone 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).

IC50 & Target

APE-1[1]
体外研究
(In Vitro)

Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. To investigate the anticancer activity of Lucanthone, cell viability is measured by MTT assay. Lucanthone reduces cell viability to a similar extent in a panel of seven breast cancer cell lines. In addition, a direct comparison reveals that Lucanthone is significantly more potent than Chloroquine (CQ) at reducing breast cancer cell viability with a mean IC50 of 7.2 μM versus 66 μM for CQ. Measurement of cell viability in two representative cell lines (MDA-MB-231 and BT-20) by ATPlite assay and trypan blue exclusion reveals comparable results[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lucanthone 相关抗体:
Clinical Trial
分子量

340.48

Formula

C20H24N2OS
CAS 号
性状

固体

颜色

Off-white to orange

中文名称

硫蒽酮；甲流葱酮；露坎松；胺甲硫葱酮；海蒽酮；甲硫恩酮；甲硫蒽酮；硫坎酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 25 mg/mL (73.43 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9370 mL 14.6852 mL 29.3703 mL
5 mM 0.5874 mL 2.9370 mL 5.8741 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Cell Assay
[2]

Cell viability is assessed by MTT assay. Cells are seeded into 96-well microculture plates at 10,000 cells per well and allowed to attach for 24 h. Cells are then treated with Lucanthone (0, 0.5, 1, 5, 10, 20 and 40 μM), Chloroquine, Vorinostat, or combinations for 72 h. Following drug treatment, MTT is added and cell viability is quantified using a BioTek microplate reader. Effects on cell viability are also determined by measuring ATP levels using the ATPlite assay system and by trypan blue exclusion. Pro-apoptotic effects following in vitro drug exposure are quantified by propidium iodide (PI) staining and fluorescence-activated cell sorting (FACS) analysis of sub-G0/G1 DNA content[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Lucanthone 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9370 mL 14.6851 mL 29.3703 mL 73.4257 mL
5 mM 0.5874 mL 2.9370 mL 5.8741 mL 14.6851 mL
10 mM 0.2937 mL 1.4685 mL 2.9370 mL 7.3426 mL
15 mM 0.1958 mL 0.9790 mL 1.9580 mL 4.8950 mL
20 mM 0.1469 mL 0.7343 mL 1.4685 mL 3.6713 mL
25 mM 0.1175 mL 0.5874 mL 1.1748 mL 2.9370 mL
30 mM 0.0979 mL 0.4895 mL 0.9790 mL 2.4475 mL
40 mM 0.0734 mL 0.3671 mL 0.7343 mL 1.8356 mL
50 mM 0.0587 mL 0.2937 mL 0.5874 mL 1.4685 mL
60 mM 0.0490 mL 0.2448 mL 0.4895 mL 1.2238 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lucanthone479-50-5硫蒽酮甲流葱酮露坎松胺甲硫葱酮海蒽酮甲硫恩酮甲硫蒽酮硫坎酮AutophagyParasiteInhibitorinhibitorinhibit

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目录号：
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