2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor Leukotriene Receptor Prostaglandin Receptor
  4. Nedocromil

Nedocromil  (Synonyms: 奈多罗米钠; FPL 59002)

目录号: HY-13448 纯度: 98.02%
COA 产品使用指南

摩尔计算器

Nedocromil 抑制多种介质的作用或形成，包括组胺，白三烯 C4 (LTC4) 和前列腺素 D2 (PGD2)。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Nedocromil Chemical Structure

Nedocromil Chemical Structure

CAS No. : 69049-73-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥880
In-stock
5 mg ￥800
In-stock
10 mg ￥1300
In-stock
25 mg ￥2600
In-stock
50 mg ￥4200
In-stock
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Other Forms of Nedocromil:

Nedocromil 相关抗体

Top Publications Citing Use of Products

查看 Histamine Receptor 亚型特异性产品:

查看所有亚型
H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

查看 Leukotriene Receptor 亚型特异性产品:

查看所有亚型
LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

查看 Prostaglandin Receptor 亚型特异性产品:

查看所有亚型
DP EP FP IP TXA2/TP TXB2

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nedocromil suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).

IC50 & Target[1]

Histamine

 

LTC4

 

PGD2

 

体外研究
(In Vitro)

Nedocromil inhibits the release of histamine, LTC4, and PGD2 from mast cells challenged with antigen (with IC30 values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively) and with anti-human IgE (IC30 values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nedocromil 相关抗体:
体内研究
(In Vivo)

Nedocromil-treated diabetic mice show significantly improved heart function compared with controls. The contractility and relaxation forces show similar improvements. However, the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice. Nedocromil can significantly improve cardiac function in mice with diabetic cardiomyopathy, but the treatment cannot restore normal function[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

371.34

Formula

C19H17NO7
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

奈多罗米
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 16.67 mg/mL (44.89 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6929 mL 13.4647 mL 26.9295 mL
5 mM 0.5386 mL 2.6930 mL 5.3859 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.02%

COA (193 KB) HNMR (254 KB) RP-HPLC (250 KB) LCMS (258 KB)

产品使用指南 (1538 KB)
参考文献
Animal Administration
[2]

Mice[2]
8-12 weeks old C57/BL6 male mice between 23-25 g receive intraperitoneal (i.p.) injections of 50 mg/kg Streptozotocin (STZ), dissolved in 100 mM citrate buffer pH 4.5, for five consecutive days. Diabetic mice (13-week-old) are randomly divided into three groups: 1) untreated group; 2) Nedocromil group, with Nedocromil released at the rate of 30 mg/kg per day from a subcutaneous (s.c.) pellet implantation; and vehicle group, with an inactive pellet implanted. Normal mice (non-diabetic) and normal mice that receive Nedocromil (30 mg/kg per day) are also included in this study for comparison. All sample groups included 15 mice (n=15)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Nedocromil 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6929 mL 13.4647 mL 26.9295 mL 67.3237 mL
5 mM 0.5386 mL 2.6929 mL 5.3859 mL 13.4647 mL
10 mM 0.2693 mL 1.3465 mL 2.6929 mL 6.7324 mL
15 mM 0.1795 mL 0.8976 mL 1.7953 mL 4.4882 mL
20 mM 0.1346 mL 0.6732 mL 1.3465 mL 3.3662 mL
25 mM 0.1077 mL 0.5386 mL 1.0772 mL 2.6929 mL
30 mM 0.0898 mL 0.4488 mL 0.8976 mL 2.2441 mL
40 mM 0.0673 mL 0.3366 mL 0.6732 mL 1.6831 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nedocromil69049-73-6FPL 59002奈多罗米FPL59002FPL-59002Histamine ReceptorLeukotriene ReceptorProstaglandin ReceptorInhibitorinhibitorinhibit

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