2. Anti-infection Autophagy NF-κB
  3. Bacterial HIV Autophagy Parasite IKK Influenza Virus
  4. Tizoxanide

Tizoxanide  (Synonyms: 替唑尼特; TIZ)

目录号: HY-12687 纯度: 99.09%
COA 产品使用指南

摩尔计算器

Tizoxanide (TIZ) 是 Nitazoxanidede 的活性代谢物，也是一种噻唑胺类抗 感染 化合物，对厌氧菌、原生动物和一系列病毒产生作用。Tizoxanide (TIZ) 具有抗 HIV-1 活性，对 HBV 和 HCV 的复制有较强的抑制作用，EC50 分别为 0.46 μM 和 0.15 μM。Tizoxanide (TIZ) 还通过抑制 LPS 处理的巨噬细胞中促炎细胞因子的产生和 NF-κB 以及 MAPK 信号通路的激活发挥抗炎作用。

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Tizoxanide Chemical Structure

Tizoxanide Chemical Structure

CAS No. : 173903-47-4

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥770
In-stock
5 mg ￥437
In-stock
10 mg ￥700
In-stock
50 mg ￥2025
In-stock
100 mg ￥3025
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Tizoxanide:

Tizoxanide 相关抗体

Top Publications Citing Use of Products

查看 HIV 亚型特异性产品:

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HIV HIV-1 HIV-2

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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IKK-α IKK-β IKK IKKε TBK1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has anti-HIV-1 activities and potent inhibition of both HBV and HCV replication with values EC50 of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells[1][3][4][5].

IC50 & Target

HIV-1

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa IC50
29.8 μM
Compound: TIZ
Cytotoxicity against human HeLa cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay
[PMID: 34055214]
HepG2 2.2.15 CC50
> 100 μM
Compound: 2
Cytotoxicity against human HepG2(2.2.15) cells after 24 hrs by neutral red dye uptake assay
Cytotoxicity against human HepG2(2.2.15) cells after 24 hrs by neutral red dye uptake assay
[PMID: 21553812]
Huh-7 CC50
14 μM
Compound: 2
Cytotoxicity against human Huh7.5 cells after 3 days by neutral red dye assay
Cytotoxicity against human Huh7.5 cells after 3 days by neutral red dye assay
[PMID: 22059983]
Vero CC50
388 μM
Compound: Tizoxanide
Cytotoxicity against African green monkey Vero cells after 48 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells after 48 hrs by MTT assay
[PMID: 25801157]
Vero CC50
388 μM
Compound: TIZ
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
[PMID: 21397502]
体外研究
(In Vitro)

Tizoxanide (TIZ) induces mild mitochondrial uncoupling and activate AMPK in hepatocytes[1].
Tizoxanide (TIZ) inhibits hepatitis C virus (HCV) replication in HCV replicon systems[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tizoxanide 相关抗体:

Cell Viability Assay[1]

Cell Line: HepG2 cells
Concentration: 1-25 µmol/L
Incubation Time: 24 h
Result: Induced mitochondrial uncoupling and AMPK activation not due to the non-specific cytotoxicity in HepG2 cells at concentrations less than 25 µmol/L.

Immunofluorescence[1]

Cell Line: HepG2 cells
Concentration: 10 µmol/L
Incubation Time: 24 h
Result: Promoted the nuclear translocation of TFEB by activating AMPK in HepG2 cells.

RT-PCR[1]

Cell Line: HepG2 cells
Concentration: 1-25 µmol/L
Incubation Time: 24 h
Result: Induced the increase transcription of SQSTM1/P62 in HepG2 cells.

Western Blot Analysis[1]

Cell Line: HepG2 cells
Concentration: 1-25 µmol/L
Incubation Time: 24 h
Result: Activated AMPK and increased phosphorylation of ACC in HepG2 cells.

Cell Cytotoxicity Assay[3]

Cell Line: RP7 cells, NTZ-11 and TIZ-9 cell lines
Concentration: The initial drug concentration was 0.02 µM, followed by 0.05, 0.1, 0.5, and 1 µM, and subsequent weekly increases of 1 µM until a final concentration of 11 µM.
Incubation Time: 3 days
Result: Againsted HCV replication in RP7 cells (IC50: 0.16), NTZ-11 (IC50:1.2) and TIZ-9 cell lines (IC50: 1.5)
体内研究
(In Vivo)

Tizoxanide (TIZ) (10 mg/kg; i.v.) can pass the BBB and distribute to the brain tissue. Tizoxanide retains in brain is obviously longer than that in plasma[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley rats[2]
Dosage: 10 mg/kg
Administration: Tizoxanide (10 mg/kg; i.v.)
Result: Could pass the BBB and distribute to the brain tissue.
分子量

265.25

Formula

C10H7N3O4S
CAS 号
性状

固体

颜色

White to yellow

中文名称

替唑尼特
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 25 mg/mL (94.25 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

Ethanol 中的溶解度 : < 1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.7700 mL 18.8501 mL 37.7003 mL
5 mM 0.7540 mL 3.7700 mL 7.5401 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： 15% Cremophor EL    85% Saline

    Solubility: 5 mg/mL (18.85 mM); 悬浊液; 超声助溶 (<60°C)

  • 方案 二

    请依序添加每种溶剂： 17% Solutol HS-15 in Saline

    Solubility: 5 mg/mL (18.85 mM); 悬浊液; 超声助溶 (<60°C)

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.09%

COA (288 KB) LCMS (94 KB)

产品使用指南 (1538 KB)
参考文献

Tizoxanide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7700 mL 18.8501 mL 37.7003 mL 94.2507 mL
5 mM 0.7540 mL 3.7700 mL 7.5401 mL 18.8501 mL
10 mM 0.3770 mL 1.8850 mL 3.7700 mL 9.4251 mL
15 mM 0.2513 mL 1.2567 mL 2.5134 mL 6.2834 mL
20 mM 0.1885 mL 0.9425 mL 1.8850 mL 4.7125 mL
25 mM 0.1508 mL 0.7540 mL 1.5080 mL 3.7700 mL
30 mM 0.1257 mL 0.6283 mL 1.2567 mL 3.1417 mL
40 mM 0.0943 mL 0.4713 mL 0.9425 mL 2.3563 mL
50 mM 0.0754 mL 0.3770 mL 0.7540 mL 1.8850 mL
60 mM 0.0628 mL 0.3142 mL 0.6283 mL 1.5708 mL
80 mM 0.0471 mL 0.2356 mL 0.4713 mL 1.1781 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tizoxanide173903-47-4TIZ替唑尼特BacterialHIVAutophagyParasiteIKKInfluenza VirusHuman immunodeficiency virusIκB kinaseI kappa B kinaseNitazoxanide AMPKHBVHCVNF-κBMAPKIKK-αparasitesvirusesanaerobicbacteriaprotozoaInhibitorinhibitorinhibit

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