2. PI3K/Akt/mTOR Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage Apoptosis Metabolic Enzyme/Protease
  3. Akt PI3K Anaplastic lymphoma kinase (ALK) CDK Apoptosis Mitochondrial Metabolism
  4. ALK/PI3K/AKT-IN-1

ALK/PI3K/AKT-IN-1 (Compound 45) 抑制癌细胞 A549、H1975 和 PC9 的增殖，IC50 分别为 0.44、0.83 和 1.51 μM。ALK/PI3K/AKT-IN-1 增加 p21 和 p27 的表达，抑制 CDK2 和 p-Rb 的活性，在 G1 期阻滞细胞周期。ALK/PI3K/AKT-IN-1 抑制 ALK/PI3K/AKT 信号通路，促进线粒体膜电位去极化，诱导 A549 细胞凋亡 (apoptosis)。ALK/PI3K/AKT-IN-1 抑制 A549 细胞球体的形成和生长。

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ALK/PI3K/AKT-IN-1 Chemical Structure

ALK/PI3K/AKT-IN-1 Chemical Structure

CAS No. : 3050831-84-7

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ALK/PI3K/AKT-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ALK/PI3K/AKT-IN-1 (Compound 45) inhibits the proliferation of cancer cell A549, H1975 and PC9 with an IC50 of 0.44, 0.83 and 1.51 μM. ALK/PI3K/AKT-IN-1 increases the expression of p21 and p27, inhibits the activity of CDK2 and p-Rb, arrests the cell cycle at G1 phase. ALK/PI3K/AKT-IN-1 inhibits the ALK/PI3K/AKT signaling pathway, promotes the depolarization of mitochondrial membrane potential, and inducing apoptosis in A549 cell. ALK/PI3K/AKT-IN-1 inhibits the formation and growth of A549 cell spheroids[1].

分子量

473.52

Formula

C25H20FN5O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ALK/PI3K/AKT-IN-1 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

ALK/PI3K/AKT-IN-13050831-84-7AktPI3KAnaplastic lymphoma kinase (ALK)CDKApoptosisMitochondrial MetabolismPKBProtein kinase BPhosphoinositide 3-kinaseAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246Cyclin dependent kinaseH1975A549PC9Inhibitorinhibitorinhibit

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