Allicin (Synonyms: 大蒜素; Diallyl thiosulfinate)

目录号: HY-N0315 纯度: 97.74%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Allicin (diallyl thiosulfinate)，一种大蒜提取物，包含 Diallyl monosulfide、Diallyl disulfide、Diallyl trisulfide、Diallyl tetrasulfide、Methyl allyl disulphide 等，占据混合物总和的 98%。Allicin (diallyl thiosulfinate) 含有高效抗菌活性，能够抑制多种微生物生长，其中包括抗抗生素菌株。

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Allicin Chemical Structure

CAS No. : 539-86-6

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥770	In-stock
50 mg	￥700	In-stock
100 mg	￥1050	In-stock
200 mg		询价
500 mg		询价

or 大包装询价

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生物活性
纯度 & 产品资料
参考文献

生物活性

Allicin (diallyl thiosulfinate) is isolated from garlic including Diallyl monosulfide, Diallyl disulfide, Diallyl trisulfide, Diallyl tetrasulfide, and Methyl allyl disulphide etc. They accounts for 98% of the extract. Allicin (diallyl thiosulfinate) has highly potent antimicrobial activity, and inhibits growth of a variety of microorganisms, among them antibiotic-resistant strains^[1]^[2].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
Daudi	IC₅₀	35.3 μM Compound: Allicin	Antiproliferative activity against human Daudi cells assessed as [methyl-3H]thymidine incorporation after 16 hrs by XTT assay Antiproliferative activity against human Daudi cells assessed as [methyl-3H]thymidine incorporation after 16 hrs by XTT assay	[PMID: 18467007]
HeLa	IC₅₀	103.5 μM Compound: Allicin	Antiproliferative activity against human HeLa cells assessed as [methyl-3H]thymidine incorporation after 16 hrs by XTT assay Antiproliferative activity against human HeLa cells assessed as [methyl-3H]thymidine incorporation after 16 hrs by XTT assay	[PMID: 18467007]
HepG2	IC₅₀	39.4 μM Compound: 120	Antimalarial activity against liver stages of Plasmodium berghei assessed as human HepG2 cells assessed as inhibition of hepatic parasite growth after invasion of hepatocytes incubated for 48 hrs followed by compound wash out measured after 2 days by RT-P Antimalarial activity against liver stages of Plasmodium berghei assessed as human HepG2 cells assessed as inhibition of hepatic parasite growth after invasion of hepatocytes incubated for 48 hrs followed by compound wash out measured after 2 days by RT-P	[PMID: 22122518]
HepG2	IC₅₀	40 μM Compound: 120	Antimalarial activity against liver stages of Plasmodium yoelii 17XNL expressing GFP infected in human HepG2 cells transfected with CD81 assessed as growth inhibition of hepatic parasite after 40 hrs by flow cytometry Antimalarial activity against liver stages of Plasmodium yoelii 17XNL expressing GFP infected in human HepG2 cells transfected with CD81 assessed as growth inhibition of hepatic parasite after 40 hrs by flow cytometry	[PMID: 22122518]
HepG2	IC₅₀	6.8 μM Compound: 120	Antimalarial activity against liver stages of Plasmodium berghei infected in human HepG2 cells assessed as growth inhibition of hepatic parasite before invasion of hepatocytes incubated for 48 hrs followed by compound wash out measured after 3 days by RT- Antimalarial activity against liver stages of Plasmodium berghei infected in human HepG2 cells assessed as growth inhibition of hepatic parasite before invasion of hepatocytes incubated for 48 hrs followed by compound wash out measured after 3 days by RT-	[PMID: 22122518]
HL-60	IC₅₀	5.5 μM Compound: Allicin	Antiproliferative activity against human HL60 cells assessed as [methyl-3H]thymidine incorporation after 16 hrs by XTT assay Antiproliferative activity against human HL60 cells assessed as [methyl-3H]thymidine incorporation after 16 hrs by XTT assay	[PMID: 18467007]
HT-29	IC₅₀	83.8 μM Compound: Allicin	Antiproliferative activity against multidrug-resistant human HT-29 cells assessed as [methyl-3H]thymidine incorporation after 16 hrs by XTT assay Antiproliferative activity against multidrug-resistant human HT-29 cells assessed as [methyl-3H]thymidine incorporation after 16 hrs by XTT assay	[PMID: 18467007]
Kelly	ED₅₀	9.21 μM Compound: Allicin	Antiproliferative activity against human Kelly cells after 24 hrs Antiproliferative activity against human Kelly cells after 24 hrs	[PMID: 32786875]
NCI-N87	IC₅₀	16.8 μM Compound: Allicin	Antiproliferative activity against human NCI-N87 cells assessed as [methyl-3H]thymidine incorporation after 16 hrs by XTT assay Antiproliferative activity against human NCI-N87 cells assessed as [methyl-3H]thymidine incorporation after 16 hrs by XTT assay	[PMID: 18467007]
SGC-7901	IC₅₀	0.5 μM Compound: Allicin	Inhibition of telomerase in human SGC7901 cells by TRAP-PCR-ELISA Inhibition of telomerase in human SGC7901 cells by TRAP-PCR-ELISA	10.1039/C0MD00241K
SK-N-AS	ED₅₀	19.48 μM Compound: Allicin	Antiproliferative activity against human SK-N-AS cells after 24 hrs Antiproliferative activity against human SK-N-AS cells after 24 hrs	[PMID: 32786875]
SK-N-BE(2)-M17	ED₅₀	10.27 μM Compound: Allicin	Antiproliferative activity against human SK-N-BE(2)-M17 cells after 24 hrs Antiproliferative activity against human SK-N-BE(2)-M17 cells after 24 hrs	[PMID: 32786875]
SK-N-FI	ED₅₀	18.06 μM Compound: Allicin	Antiproliferative activity against human SK-N-FI cells after 24 hrs Antiproliferative activity against human SK-N-FI cells after 24 hrs	[PMID: 32786875]
U-937	IC₅₀	19.7 μM Compound: Allicin	Antiproliferative activity against human U937 cells assessed as [methyl-3H]thymidine incorporation after 16 hrs by XTT assay Antiproliferative activity against human U937 cells assessed as [methyl-3H]thymidine incorporation after 16 hrs by XTT assay	[PMID: 18467007]

体外研究
(In Vitro)

Allicin 对耐甲氧西林金黄色葡萄球菌 ATCC 43300、典型菌株金黄色葡萄球菌 DSM 20231、大肠杆菌 DSM 30083、鲍曼不动杆菌 DSM 30007 和白色念珠菌 DSM 1386的 MIC 为 32-64 μg/mL^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

162.27

Formula

C₆H₁₀OS₂

CAS 号

539-86-6

性状

液体（密度：1.112 g/cm³）

颜色

Colorless to light yellow

中文名称

大蒜素；蒜素

结构分类

Others

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

细胞实验：

DMSO 中的溶解度 : 100 mg/mL (616.26 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

Ethanol 中的溶解度 : 70 mg/mL (431.38 mM; 超声助溶)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	6.1626 mL	30.8128 mL	61.6257 mL
5 mM	1.2325 mL	6.1626 mL	12.3251 mL
10 mM	0.6163 mL	3.0813 mL	6.1626 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 3.5 mg/mL (21.57 mM); 澄清溶液

此方案可获得 ≥ 3.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 35.0 mg/mL 的澄清 EtOH 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 3.5 mg/mL (21.57 mM); 澄清溶液

此方案可获得 ≥ 3.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 35.0 mg/mL 的澄清 EtOH 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
方案三

请依序添加每种溶剂： 10% EtOH 90% Corn Oil
Solubility: ≥ 3.5 mg/mL (21.57 mM); 澄清溶液

此方案可获得 ≥ 3.5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 35.0 mg/mL 的澄清 EtOH 储备液加到 900 μL 玉米油中，混合均匀。
方案四

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 3.25 mg/mL (20.03 mM); 悬浊液; 超声助溶

此方案可获得 3.25 mg/mL的均匀悬浊液，悬浊液可用于口服和腹腔注射。
以 1 mL 工作液为例，取 100 μL 32.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案五

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 3.25 mg/mL (20.03 mM); 澄清溶液

此方案可获得 ≥ 3.25 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 32.5 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
方案六

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 3.25 mg/mL (20.03 mM); 澄清溶液

此方案可获得 ≥ 3.25 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 32.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: ≥98.0%

选择批次：

Data Sheet (629 KB) SDS (392 KB)

COA (188 KB) RP-HPLC (202 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Rahman, et al. Allicin and Other Functional Active Components in Garlic: Health Benefits and Bioavailability[J]. International Journal of Food Properties, 2007, 10(2):245-268.

[2]. Müller A, et al. Allicin Induces Thiol Stress in Bacteria through S-Allylmercapto Modification of ProteinCysteines. J Biol Chem. 2016 May 27;291(22):11477-90. [Content Brief]

Allicin 相关分类

Infection

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

Ethanol / DMSO	1 mM	6.1626 mL	30.8128 mL	61.6257 mL	154.0642 mL
	5 mM	1.2325 mL	6.1626 mL	12.3251 mL	30.8128 mL
	10 mM	0.6163 mL	3.0813 mL	6.1626 mL	15.4064 mL
	15 mM	0.4108 mL	2.0542 mL	4.1084 mL	10.2709 mL
	20 mM	0.3081 mL	1.5406 mL	3.0813 mL	7.7032 mL
	25 mM	0.2465 mL	1.2325 mL	2.4650 mL	6.1626 mL
	30 mM	0.2054 mL	1.0271 mL	2.0542 mL	5.1355 mL
	40 mM	0.1541 mL	0.7703 mL	1.5406 mL	3.8516 mL
	50 mM	0.1233 mL	0.6163 mL	1.2325 mL	3.0813 mL
	60 mM	0.1027 mL	0.5135 mL	1.0271 mL	2.5677 mL
	80 mM	0.0770 mL	0.3852 mL	0.7703 mL	1.9258 mL
	100 mM	0.0616 mL	0.3081 mL	0.6163 mL	1.5406 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Allicin539-86-6Diallyl thiosulfinate大蒜素蒜素BacterialAntibioticInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Allicin (Synonyms: 大蒜素; Diallyl thiosulfinate)

Customer Review

MCE 顾客使用本产品发表的 6 篇科研文献