2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Apoptosis
  3. Topoisomerase Androgen Receptor Estrogen Receptor/ERR Apoptosis
  4. Alternariol

Alternariol  (Synonyms: 交链孢酚)

目录号: HY-N6714 纯度: 99.55%
COA 产品使用指南

摩尔计算器

Alternariol 是一种由 Alternaria 产生的可口服霉菌毒素，能够抑制拓扑异构酶 I 和 II (topoisomerase I，topoisomerase II) 的活性，具有弱雌激素 (Estrogen Receptor/ERR) 及雄激素/抗雄激素 (Androgen Receptor) 效应。Alternariol 能诱导细胞凋亡，引发细胞周期停滞，抑制先天免疫反应，并展现抗肿瘤活性。Alternariol 具有遗传毒性、诱变性和内分泌干扰作用。

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Alternariol Chemical Structure

Alternariol Chemical Structure

CAS No. : 641-38-3

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Other Forms of Alternariol:

Alternariol 相关抗体

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Topoisomerase Topo I Topo II

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects[1][2][3][4][5].

体外研究
(In Vitro)

Alternariol (10 μM，24 h) 抑制人肺上皮细胞 (BEAS-2B) 和小鼠巨噬细胞 (RAW264.7) 的先天免疫反应[2]。
Alternariol (5-10 μM，24 h) 在 LPS (HY-D1056，10 μg) 诱导的 BEAS-2B 细胞炎症中呈剂量依赖性降低[2]。
Alternariol (1-100 μM，24 h) 抑制 BEAS-2B 细胞增殖，诱导细胞周期阻滞[2]。
Alternariol (10 μM，24 h) 在 V79 细胞和小鼠淋巴瘤 L5178Y tk+/− 细胞 (MLC) 中诱导 HPRT 和 TK 突变[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Alternariol 相关抗体:

Real Time qPCR[2]

Cell Line: BEAS-2B, RAW264.7 (induced by LPS)
Concentration: 10 μM
Incubation Time: 24 h
Result: Reduced IL6, IL8, MCP-1/CCL2 levels, induced cytochrome P450 CYP1A1 gene expression, and partially prevented LPS-induced downregulation.

Cell Viability Assay[2]

Cell Line: BEAS-2B
Concentration: 1, 5, 10, 15, 20, 25, 30, 50, 100 μM
Incubation Time: 24 h
Result: Inhibited cell proliferation, but not cell death.
体内研究
(In Vivo)

Alternariol (1-5 mg/kg，静脉注射，每日一次，4 天) 对小鼠胚胎和婴儿发育阶段具有胚胎毒性和免疫毒性，诱导凋亡[4]。
Alternariol (50-200 mg/kg，口服，每天一次，24 周) 在 DMBA (HY-W011845) 诱导的乳腺癌小鼠中诱导细胞凋，和抑制细胞增殖，可以显著抑制乳腺癌[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pregnant mice[4]
Dosage: 1, 3, 5 mg/kg; daily; 4 days
Administration: Intravenous injection (i.v.)
Result: Showed embryonic apoptosis at the blastocyst stage, fetal weight loss, triggering a significant increase in total oxidative stress content and expression of genes encoding antioxidant proteins, and reducing the expression of CXCL1, IL-1β and IL-8.
Animal Model: Mice induced by DMBA(HY-W011845)[5]
Dosage: 50, 100, 200 mg/kg; daily; 24 weeks
Administration: Oral
Result: Reduced proliferative lesions of breast tissue, restored normal histopathological characteristics of breast tissue, downregulated the expression of oncogenic markers such as PI3K and Akt, increased the expression of apoptosis markers such as p53, caspase-3 and Bax, reduced cell proliferation and increased cell apoptosis.
分子量

258.23

Formula

C14H10O5
CAS 号
性状

固体

颜色

Off-white to light brown

中文名称

交链孢酚
结构分类
初始来源

fungi of the genus Alternaria
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: 99.55%

COA (288 KB) HNMR (104 KB) RP-HPLC (102 KB)

产品使用指南 (1538 KB)
参考文献

Alternariol 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alternariol641-38-3交链孢酚TopoisomeraseAndrogen ReceptorEstrogen Receptor/ERRApoptosisanti-tumormutagenesisgenotoxicityinnate immunityInhibitorinhibitorinhibit

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