2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Apoptosis
  3. Topoisomerase Androgen Receptor Estrogen Receptor/ERR Apoptosis
  4. Alternariol

Alternariol  (Synonyms: 交链孢酚)

目录号: HY-N6714 纯度: 99.67%
COA 产品使用指南 技术支持

Alternariol 是一种由 Alternaria 产生的可口服霉菌毒素，能够抑制拓扑异构酶 I 和 II (topoisomerase I，topoisomerase II) 的活性，具有弱雌激素 (Estrogen Receptor/ERR) 及雄激素/抗雄激素 (Androgen Receptor) 效应。Alternariol 能诱导细胞凋亡，引发细胞周期停滞，抑制先天免疫反应，并展现抗肿瘤活性。Alternariol 具有遗传毒性、诱变性和内分泌干扰作用。

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Alternariol Chemical Structure

Alternariol Chemical Structure

CAS No. : 641-38-3

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规格 价格 是否有货 数量
1 mg ￥2700
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Customer Review

Other Forms of Alternariol:

Alternariol 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

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Topoisomerase Topo I Topo II

查看 Estrogen Receptor/ERR 亚型特异性产品:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects[1][2][3][4][5].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780 IC50
> 10 μM
Compound: 12
Cytotoxicity against human A2780 cells by MTT assay
Cytotoxicity against human A2780 cells by MTT assay
[PMID: 27441892]
BGC-823 IC50
> 10 μM
Compound: 12
Cytotoxicity against human BGC823 cells by MTT assay
Cytotoxicity against human BGC823 cells by MTT assay
[PMID: 27441892]
HCT-116 IC50
> 10 μM
Compound: 12
Cytotoxicity against human HCT116 cells by MTT assay
Cytotoxicity against human HCT116 cells by MTT assay
[PMID: 27441892]
HepG2 IC50
> 10 μM
Compound: 12
Cytotoxicity against human HepG2 cells by MTT assay
Cytotoxicity against human HepG2 cells by MTT assay
[PMID: 27441892]
HT-29 IC50
> 20 μM
Compound: 17
Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay
[PMID: 28409637]
L5178Y EC50
1.7 μg/mL
Compound: 1
Cytotoxicity against mouse L5178Y cells by MTT assay
Cytotoxicity against mouse L5178Y cells by MTT assay
[PMID: 18494522]
MCF7 IC50
> 20 μM
Compound: 17
Cytotoxicity against human MCF7 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human MCF7 cells after 3 days by sulforhodamine B assay
[PMID: 28409637]
NCI-H1650 IC50
> 10 μM
Compound: 12
Cytotoxicity against human NCI-H1650 cells by MTT assay
Cytotoxicity against human NCI-H1650 cells by MTT assay
[PMID: 27441892]
RAW264.7 IC50
51.4 μM
Compound: 14
Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs by Griess reagent assay
Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs by Griess reagent assay
[PMID: 35007071]
体外研究
(In Vitro)

Alternariol (10 μM，24 h) 抑制人肺上皮细胞 (BEAS-2B) 和小鼠巨噬细胞 (RAW264.7) 的先天免疫反应[2]。
Alternariol (5-10 μM，24 h) 在 LPS (HY-D1056，10 μg) 诱导的 BEAS-2B 细胞炎症中呈剂量依赖性降低[2]。
Alternariol (1-100 μM，24 h) 抑制 BEAS-2B 细胞增殖，诱导细胞周期阻滞[2]。
Alternariol (10 μM，24 h) 在 V79 细胞和小鼠淋巴瘤 L5178Y tk+/− 细胞 (MLC) 中诱导 HPRT 和 TK 突变[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Alternariol 相关抗体:

Real Time qPCR[2]

Cell Line: BEAS-2B, RAW264.7 (induced by LPS)
Concentration: 10 μM
Incubation Time: 24 h
Result: Reduced IL6, IL8, MCP-1/CCL2 levels, induced cytochrome P450 CYP1A1 gene expression, and partially prevented LPS-induced downregulation.

Cell Viability Assay[2]

Cell Line: BEAS-2B
Concentration: 1, 5, 10, 15, 20, 25, 30, 50, 100 μM
Incubation Time: 24 h
Result: Inhibited cell proliferation, but not cell death.
体内研究
(In Vivo)

Alternariol (1-5 mg/kg，静脉注射，每日一次，4 天) 对小鼠胚胎和婴儿发育阶段具有胚胎毒性和免疫毒性，诱导凋亡[4]。
Alternariol (50-200 mg/kg，口服，每天一次，24 周) 在 DMBA (HY-W011845) 诱导的乳腺癌小鼠中诱导细胞凋，和抑制细胞增殖，可以显著抑制乳腺癌[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pregnant mice[4]
Dosage: 1, 3, 5 mg/kg; daily; 4 days
Administration: Intravenous injection (i.v.)
Result: Showed embryonic apoptosis at the blastocyst stage, fetal weight loss, triggering a significant increase in total oxidative stress content and expression of genes encoding antioxidant proteins, and reducing the expression of CXCL1, IL-1β and IL-8.
Animal Model: Mice induced by DMBA(HY-W011845)[5]
Dosage: 50, 100, 200 mg/kg; daily; 24 weeks
Administration: Oral
Result: Reduced proliferative lesions of breast tissue, restored normal histopathological characteristics of breast tissue, downregulated the expression of oncogenic markers such as PI3K and Akt, increased the expression of apoptosis markers such as p53, caspase-3 and Bax, reduced cell proliferation and increased cell apoptosis.
分子量

258.23

Formula

C14H10O5
CAS 号
性状

固体

颜色

White to light brown

中文名称

交链孢酚
结构分类
初始来源

fungi of the genus Alternaria
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 30 mg/mL (116.18 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.8725 mL 19.3626 mL 38.7252 mL
5 mM 0.7745 mL 3.8725 mL 7.7450 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.67%

COA (289 KB) HNMR (105 KB) LCMS (93 KB)

产品使用指南 (1538 KB)
参考文献

Alternariol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8725 mL 19.3626 mL 38.7252 mL 96.8129 mL
5 mM 0.7745 mL 3.8725 mL 7.7450 mL 19.3626 mL
10 mM 0.3873 mL 1.9363 mL 3.8725 mL 9.6813 mL
15 mM 0.2582 mL 1.2908 mL 2.5817 mL 6.4542 mL
20 mM 0.1936 mL 0.9681 mL 1.9363 mL 4.8406 mL
25 mM 0.1549 mL 0.7745 mL 1.5490 mL 3.8725 mL
30 mM 0.1291 mL 0.6454 mL 1.2908 mL 3.2271 mL
40 mM 0.0968 mL 0.4841 mL 0.9681 mL 2.4203 mL
50 mM 0.0775 mL 0.3873 mL 0.7745 mL 1.9363 mL
60 mM 0.0645 mL 0.3227 mL 0.6454 mL 1.6135 mL
80 mM 0.0484 mL 0.2420 mL 0.4841 mL 1.2102 mL
100 mM 0.0387 mL 0.1936 mL 0.3873 mL 0.9681 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alternariol641-38-3交链孢酚TopoisomeraseAndrogen ReceptorEstrogen Receptor/ERRApoptosisanti-tumormutagenesisgenotoxicityinnate immunityInhibitorinhibitorinhibit

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