2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. ATP disodium salt hydrate

ATP disodium salt hydrate  (Synonyms: Adenosine 5'-triphosphate disodium salt hydrate)

目录号: HY-W010735 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

ATP disodium salt hydrate (Adenosine 5'-triphosphate disodium salt hydrate) 是体内能量储存和代谢的重要物质，为代谢提供能量，同时在细胞中作为辅酶发挥作用。ATP disodium salt hydrate 是免疫和炎症中重要的内源性信号分子。

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ATP disodium salt hydrate Chemical Structure

ATP disodium salt hydrate Chemical Structure

CAS No. : 34369-07-8

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500 mg ￥350
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1 g ￥450
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5 g ￥900
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Customer Review

Other Forms of ATP disodium salt hydrate:

ATP disodium salt hydrate 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 69 篇科研文献

WB

    ATP disodium salt hydrate purchased from MCE. Usage Cited in: Transl Res. 2022.

    LPS/ATP treatment significantly promotes expression of NLRP3 and production of N-GSDMD in HAEC. HAEC are pretreated with LPS (500ng/ml) for 5 h and then stimulated with ATP (5 mM) for 1 h.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    ATP disodium salt hydrate (Adenosine 5'-triphosphatedisodium salt hydrate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt hydrate is an important endogenous signaling molecule in immunity and inflammation[1][2].

    IC50 & Target

    Human Endogenous Metabolite

     

    体外研究
    (In Vitro)

    ATP disodium salt hydrate (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
    ? ATP disodium salt hydrate (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner[4].
    ? ATP disodium salt hydrate stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    ATP disodium salt hydrate 相关抗体:
    体内研究
    (In Vivo)

    ATP disodium salt hydrate (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4].
    ? ATP disodium salt hydrate induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Four-week-old Kunming mice (18-22 g)[4]
    Dosage: 50 mg/kg
    Administration: Intraperitoneal injection, before bacterial (E. coli) challenge
    Result: Protected mice from bacterial infection.
    Formula

    C10H14N5O13Na2P3.xH2O
    CAS 号
    性状

    固体

    颜色

    White to off-white

    中文名称

    腺苷-5'-三磷酸二钠盐水合物
    结构分类
    初始来源

    widespread
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性数据
    细胞实验： 

    H2O 中的溶解度 : 100 mg/mL (超声助溶)

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物实验：

    以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

    • 方案 一

      请依序添加每种溶剂： PBS

      Solubility: 100 mg/mL; 澄清溶液; 超声助溶

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: ≥98.0%

    COA (290 KB) HNMR (162 KB)

    产品使用指南 (1538 KB)
    参考文献

    ATP disodium salt hydrate 相关分类

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    ATP disodium salt34369-07-8Adenosine 5'-triphosphate disodium salt腺苷-5'-三磷酸二钠盐水合物Endogenous MetaboliteenergystoragemetabolismimmunityinflammationNLRP3inflammasomecytokineInhibitorinhibitorinhibit

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    产品名称：
    ATP disodium salt hydrate
    目录号：
    HY-W010735
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