2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. β3-AR agonist 1

β3-AR agonist 1 (compound 15) 是一种高效选择性的，可口服的 β3-肾上腺素能受体 (β3-AR) 激动剂 (EC50=18 nM)，对 β1-、β2-、α1A-AR 无活性 (β1/β3, β2/β3, α1A/β3>556倍)。

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β3-AR agonist 1 Chemical Structure

β3-AR agonist 1 Chemical Structure

CAS No. : 1283125-73-4

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β3-AR agonist 1 相关抗体

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α adrenergic receptor β adrenergic receptor

  • 生物活性

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生物活性

β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold)[1].

IC50 & Target

EC50: 18 nM (β3-AR)[1]
体内研究
(In Vivo)

β3-AR agonist 1 (compound 15) shows dose-dependent β3-AR-mediated responses in marmoset urinary bladder smooth muscle, has a desirable metabolic stability and pharmacokinetic profile (Cmax and AUC), and do not obviously affect heart rate or mean blood pressure when administered intravenously (3 mg/kg) to anesthetized rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

444.55

Formula

C22H28N4O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

β3-AR agonist 1 相关分类

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Keywords:

β3-AR agonist 11283125-73-4Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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