2. Membrane Transporter/Ion Channel Neuronal Signaling GPCR/G Protein Immunology/Inflammation
  3. GABA Receptor 5-HT Receptor Dopamine Receptor Histamine Receptor
  4. BL-1020 mesylate

BL-1020 mesylate 是 BL-1020 的甲磺酸盐形式。BL-1020 mesylate 是一种抗精神病剂。BL-1020 mesylate 是多巴胺受体 dopamine receptor 和血清素受体 (5-HT receptor) 的抑制剂，对 D2L、D2S 和 5-HT2A 受体的 Ki 分别为 0.066、0.062 和 0.21 nM。BL-1020 mesylate 是 GABAA 受体 (GABAA receptor) 的激动剂，可增强 GABA 释放，Ki 为 3.74 μM。BL-1020 mesylate 对组胺受体 (histamine receptor) 具有高亲和力 (Ki 为 0.47 nM)。BL-1020 mesylate 可降低 Amphetamine 诱导的多动症，并降低肌肉僵硬和镇静作用。BL-1020 mesylate 可穿透血脑屏障。

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BL-1020 mesylate Chemical Structure

BL-1020 mesylate Chemical Structure

CAS No. : 916898-61-8

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BL-1020 mesylate 相关抗体

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生物活性

BL-1020 mesylate is the mesylate salt form of BL-1020. BL-1020 mesylate is an antipsychotic agent. BL-1020 mesylate is inhibitor for dopamine receptor and serotonin receptor (5-HT receptor), with Ki of 0.066, 0.062 and 0.21 nM, for D2L, D2S and 5-HT2A receptors, respectively. BL-1020 mesylate is agonist for GABAA receptor with Ki of 3.74 μM, and enhances the GABA release. BL-1020 mesylate exhibits high affinity with histamine receptor (Ki is 0.47 nM). BL-1020 mesylate reduces Amphetamine-induced hyperactivity, with lower catalepsy and sedation. BL-1020 mesylate is blood-brain barrier penetrate[1].

IC50 & Target

D2L Receptor

0.066 nM (Ki)

Histamine Receptor

0.47 nM (Ki)

5-HT2A Receptor

3.74 μM (Ki)

分子量

585.18

Formula

C26H37ClN4O5S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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参考文献

BL-1020 mesylate 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

BL-1020916898-61-8BL1020BL 1020GABA Receptor5-HT ReceptorDopamine ReceptorHistamine ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorschizophreniaantipsychoticcatalepsyBBB penetrateWistar ratsInhibitorinhibitorinhibit

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