2. Immunology/Inflammation Neuronal Signaling GPCR/G Protein
  3. NO Synthase Adrenergic Receptor
  4. Celiprolol hydrochloride

Celiprolol hydrochloride  (Synonyms: 盐酸塞利洛尔)

目录号: HY-B1264 纯度: 98.93%
COA 产品使用指南

摩尔计算器

Celiprolol (REV 5320) 是一种有效的，具有口服活性的心脏选择性的 β1-雄激素受体 (β1-andrenoceptor) 拮抗剂，具有部分 β2 激动剂活性，其 Ki 值为0.14-8.3 μM。Celiprolol 具有降压和抗心绞痛的活性，可被用于高血压等心血管疾病的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Celiprolol hydrochloride Chemical Structure

Celiprolol hydrochloride Chemical Structure

CAS No. : 57470-78-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥500
In-stock
5 mg ￥1100
In-stock
10 mg ￥1760
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Celiprolol hydrochloride:

Celiprolol hydrochloride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 NO Synthase 亚型特异性产品:

查看所有亚型
nNOS iNOS eNOS

查看 Adrenergic Receptor 亚型特异性产品:

查看所有亚型
α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Celiprolol (REV 5320) is a potent, cardioselective and orally active β1-andrenoceptor r antagonist with partial β2 agonist activity, with Ki values of 0.14-8.3 μM. Celiprolol has antihypertensive and antianginal activity, and can be used for the research of cardiovascular disease such as high blood pressure[1][4].

IC50 & Target[4]

β adrenergic receptor

0.14-8.3 μM (Ki)

体外研究
(In Vitro)

Celiprolol hydrochloride (0-3 mM, 90 min) is uptaken by human small intestinal transporter OATP-A/1A2 in Xenopus Laevis oocytes[5].
Celiprolol hydrochloride (10 μM, 0-50 min) is transported across human intestinal epithelial (Caco-2) cells by mediation of multiple transporters including P-glycoprotein[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Celiprolol hydrochloride 相关抗体:
体内研究
(In Vivo)

Celiprolol hydrochloride (Oral administration, 100 mg/kg/day for 31 days) improves endothelial function in the arteries of in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, and restores it 4 weeks after endothelial denudation in the arteries of OLETF rats[2].
Celiprolol hydrochloride (Treated in drinking water, 10 mg/kg/day for 5 weeks) suppresses VCAM-1 expression by inhibition of oxidative stress, NF-κB, signal transduction, and increases eNOS via stimulation of the PI3K-Akt pathway, and improves cardiovascular remodeling in deoxycorticosterone acetate (DOCA)-salt hypertensive rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Type II male Otsuka Long-Evans Tokushima Fatty (OLETF) diabetic rats[2]
Dosage: 100 mg/kg/day for 31 days
Administration: Oral administration
Result: Improved acetylcholine-induced NO-dependent relaxation in arteries.
Improved tone-related basal NO release and acetylcholine-induced NO-dependent relaxation in the arteries and plasma NOx.
Animal Model: Deoxycorticosterone acetate (DOCA)-salt hypertensive rats [3]
Dosage: 10 mg/kg/d for 5 weeks
Administration: Treated in drinking water
Result: Activated phosphorylation of eNOS through the PI3K-Akt signaling pathway.
Modulated VCAM-1 expression, which is associated with inhibition of NF-κB phosphorylation.
Reduced production of ROS by suppressing NAD(P)H oxidase subunit p22phox, p47phox, gp91phox, and nox1 expression.
Clinical Trial
分子量

415.95

Formula

C20H34ClN3O4
CAS 号
性状

固体

颜色

White to off-white

中文名称

盐酸塞利洛尔
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (300.52 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : ≥ 50 mg/mL (120.21 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4041 mL 12.0207 mL 24.0414 mL
5 mM 0.4808 mL 2.4041 mL 4.8083 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Celiprolol hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.4041 mL 12.0207 mL 24.0414 mL 60.1034 mL
5 mM 0.4808 mL 2.4041 mL 4.8083 mL 12.0207 mL
10 mM 0.2404 mL 1.2021 mL 2.4041 mL 6.0103 mL
15 mM 0.1603 mL 0.8014 mL 1.6028 mL 4.0069 mL
20 mM 0.1202 mL 0.6010 mL 1.2021 mL 3.0052 mL
25 mM 0.0962 mL 0.4808 mL 0.9617 mL 2.4041 mL
30 mM 0.0801 mL 0.4007 mL 0.8014 mL 2.0034 mL
40 mM 0.0601 mL 0.3005 mL 0.6010 mL 1.5026 mL
50 mM 0.0481 mL 0.2404 mL 0.4808 mL 1.2021 mL
60 mM 0.0401 mL 0.2003 mL 0.4007 mL 1.0017 mL
80 mM 0.0301 mL 0.1503 mL 0.3005 mL 0.7513 mL
100 mM 0.0240 mL 0.1202 mL 0.2404 mL 0.6010 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Celiprolol57470-78-7盐酸塞利洛尔NO SynthaseAdrenergic ReceptorNitric oxide synthasesNOSBeta ReceptorAndrenoceptorantihypertensiveantianginaloxidative stressnitric oxideNOdiabetesβ antagonistsβ-blockersP-glycoproteinintestinal transportintestinal secretionCaco-2 cellInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Celiprolol hydrochloride
目录号：
HY-B1264
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z