2. Immunology/Inflammation
  3. Cyclic GMP-AMP Synthase
  4. cGAS-IN-4

cGAS-IN-4 (Compound 36) 是口服有效的环状 GMP-AMP 合酶 (cGAS) 抑制剂，对 h-cGAS 和 m-cGAS 的 IC50 为 32 nM 和 5.8 nM。cGAS-IN-4 在 THP-1 cell 细胞中抑制 cGAMP，IC50 为 60 nM，从而提高细胞效力。cGAS-IN-4 在小鼠模型中对 Concanavalin A (HY-P2149) 诱发的急性肝损伤表现出抗炎作用。

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cGAS-IN-4 Chemical Structure

cGAS-IN-4 Chemical Structure

CAS No. : 2987886-49-5

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cGAS-IN-4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

cGAS-IN-4 (Compound 36) is an orally active inhibitor for cyclic GMP-AMP synthase (cGAS) with IC50 of 32 nM and 5.8 nM for h-cGAS and m-cGAS. cGAS-IN-4 inhibits the cGAMP in THP-1 cell with an IC50 of 60 nM, which improves the cellular potency. cGAS-IN-4 exhibits anti-inflammatory efficacy in Concanavalin A (HY-P2149)-induced acute liver injury in mouse models[1]. orally active, THP-1, C57Bl/6 mouse, orally active

分子量

421.28

Formula

C19H18Cl2N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

cGAS-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cGAS-IN-42987886-49-5Cyclic GMP-AMP SynthasecGASorally activeTHP-1C57Bl/6 mouse,Inhibitorinhibitorinhibit

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目录号：
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