2. 多肽产品
  3. 多肽及其衍生物
  4. 抑制剂与底物肽
  5. Endothelin-2 (49-69), human TFA

Endothelin-2 (49-69), human TFA  (Synonyms: Endothelin-2 (49-69) (human, canine) TFA; Human endothelin-2 TFA)

目录号: HY-P0207A 纯度: 98.78%
COA 产品使用指南 技术支持

Endothelin-2 (49-69), human (TFA) (Endothelin-2 (49-69) (human, canine) (TFA)) 是由 21 个氨基酸组成的血管活性肽，可与 G 蛋白连接的跨膜受体，ET-RA 和 ET-RB 结合。

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Custom Peptide Synthesis

Endothelin-2 (49-69), human TFA Chemical Structure

Endothelin-2 (49-69), human TFA Chemical Structure

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规格 价格 是否有货 数量
500 μg ￥2750
In-stock
1 mg ￥4400
In-stock
5 mg 现货 询价
10 mg   询价  
50 mg   询价  

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Customer Review

Other Forms of Endothelin-2 (49-69), human TFA:

Endothelin-2 (49-69), human TFA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Endothelin-2 (49-69), human (TFA) (Endothelin-2 (49-69) (human, canine) (TFA)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

体外研究
(In Vitro)

At nanomolar concentrations, Endothelin-2 exhibits a strong and long-lasting vasoconstrictor activity characteristic of endothelin (EC50=0.52 nM)[1].
Endothelin-2 is a chemoattractant for macrophages and THP-1 monocytic cells, but not for freshly isolated monocytes. The chemotactic response to Endothelin-2 shows a typical bell-shaped response curve. Experiments with endothelin receptor antagonists shows that migration to Endothelin-2 is mediated via the ET-RB receptor. Endothelin-2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Endothelin-2 (49-69), human TFA 相关抗体:
体内研究
(In Vivo)

Two distinct phases of pressor effects are typically seen in response to Endothelin-2: the early phase immediately follows the depressor response and dominates during the next 3-10 min, whereas the late pressor effect develops 10-20 min after the injection and lasts >1 hr[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2660.94

Formula

C117H161N26F3O34S4
性状

固体

颜色

White to off-white

Sequence

Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridge: Cys1-Cys15, Cys3-Cys11)
Sequence Shortening

CSCSSWLDKECVYFCHLDIIW (Disulfide bridge: Cys1-Cys15, Cys3-Cys11)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 50 mg/mL (18.79 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : 6.67 mg/mL (2.51 mM; 超声助溶; 酸性条件溶解 (HCL 调节，pH≈3))

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.3758 mL 1.8790 mL 3.7581 mL
5 mM 0.0752 mL 0.3758 mL 0.7516 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Endothelin-2 (49-69), human TFA 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 0.3758 mL 1.8790 mL 3.7581 mL 9.3952 mL
DMSO 5 mM 0.0752 mL 0.3758 mL 0.7516 mL 1.8790 mL
10 mM 0.0376 mL 0.1879 mL 0.3758 mL 0.9395 mL
15 mM 0.0251 mL 0.1253 mL 0.2505 mL 0.6263 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Endothelin-2 (49-69), humanEndothelin-2 (49-69) (human, canine)Human endothelin-2Human endothelin2Human endothelin 2Others21-aminoacidvasoactivepeptideG-protein-linkedtransmembraneET-RAET-RBInhibitorinhibitorinhibit

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Endothelin-2 (49-69), human TFA
目录号：
HY-P0207A
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