2. Gene
  3. LANCL1 - LanC like glutathione S-transferase 1 Gene

LANCL1 - LanC like glutathione S-transferase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：LanC 样谷胱甘肽 S-转移酶 1

种属: Homo sapiens

同用名: p40; GPR69A

基因 ID: 10314 | 基因类型: protein coding

关于 LANCL1

Cytogenetic location: 2q34 Genomic coordinates (GRCh38): 2:210,431,251-210,477,584 (from NCBI)

This gene has 8 transcripts (splice variants), 208 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 58.9), testis (RPKM 27.8) and 24 other tissues.

功能概要

该基因编码一种松散相关的外周膜蛋白，该蛋白与参与抗菌肽生物合成的细菌膜相关蛋白 LanC 家族相关。这种蛋白质可能在真核细胞中作为肽修饰酶成分发挥作用。以前被认为是 G 蛋白偶联受体超家族的成员，该蛋白现在属于 LanC 家族。已经鉴定出编码相同蛋白质的多个可变剪接变体。[RefSeq 提供，2008 年 11 月]

This gene encodes a loosely associated peripheral membrane protein related to the LanC family of Bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial Peptides. This protein may play a role as a peptide-modifying Enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]

LANCL1 基因产物(3)

mRNA Protein Name
NM_001136574.2 NP_001130046.1 glutathione S-transferase LANCL1
NM_001136575.2 NP_001130047.1 glutathione S-transferase LANCL1
NM_006055.3 NP_006046.1 glutathione S-transferase LANCL1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SH3 domain binding IPI
IPI: 通过物理相互作用推断
19528316 GOA
enables glutathione binding IDA
IDA: 通过直接分析推断
19528316 GOA
enables low-density lipoprotein particle receptor binding IDA
IDA: 通过直接分析推断
15082773 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17500595 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
19528316 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
10944443 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
NOT located in plasma membrane IDA
IDA: 通过直接分析推断
10944443 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LANCL1 蛋白结构

LANC_like

LANC_like: Lanthionine synthetase C-like protein (56 - 399)

  • 0
  • 100
  • 200
  • 300
  • 399 a.a.
蛋白主名 其他名称

glutathione S-transferase LANCL1

40 kDa erythrocyte membrane protein

LANCL1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LANCL1 O43813 BAIAP2L1 Homo sapiens Q9UHR4
Validated Y2H
32296183
种属内
LANCL1 O43813 BAIAP2L1 Homo sapiens Q9UHR4
Y2H Array
32296183
种属内
LANCL1 O43813 BAIAP2L1 Homo sapiens Q9UHR4
Y2H Prey Pooling
32296183
种属间
LANCL1 O43813 Eps8 Mus musculus Q08509
SPR
19528316
种属内
LANCL1 O43813 HTT Homo sapiens P42858
Y2H Array
32814053
种属内
LANCL1 O43813 HTT Homo sapiens P42858
Validated Y2H
32814053
种属内
LANCL1 O43813 HTT Homo sapiens P42858
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2

CMT2E

CMT2S

CMT2Y

Charcot-Marie-Tooth Disease Type 2e

Charcot-Marie-Tooth Disease Type 2y

Charcot-Marie-Tooth Disease Axonal Type 2s

Charcot-Marie-Tooth Disease, Axonal, Type 2s

Charcot-Marie-Tooth Disease, Type 2e

Hereditary Motor And Sensory Neuropathy Type 2

Charcot-Marie-Tooth Neuropathy, Type 2s

Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s

Charcot-Marie-Tooth Disease, Axonal, Type 2y

Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y

Charcot-Marie-Tooth Neuropathy, Type 2y

Charcot-Marie-Tooth Disease, Type 2y

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e

Charcot-Marie-Tooth Neuropathy Type 2e

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation

Cmt2 Due To Vcp Mutation

Charcot-Marie-Tooth Disease Type 2s

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2

Autosomal Dominant Axonal Charcot-Marie-Tooth Disease

Cmt2

Charcot-Marie-Tooth Neuropathy, Type 2e

Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type

Hereditary Motor And Sensory Neuropathy Okinawa Type

Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y

Charcot-Marie-Tooth Neuropathy Type 2y

Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s

Charcot-Marie-Tooth Neuropathy Type 2s

Charcot-Marie-Tooth Type 2

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y

Charcot-Marie-Tooth Disease 2e

Charcot-Marie-Tooth Disease Axonal Type 2e

Charcot-Marie-Tooth Disease Neuronal Type 2e

Charcot-Marie-Tooth Disease 2s

Charcot-Marie-Tooth Neuropathy Axonal Type 2s

Charcot-Marie-Tooth Disease 2y

Charcot-Marie-Tooth Disease, Type 2

Hereditary Motor And Sensory-Neuropathy Type Ii
Overhydrated Hereditary Stomatocytosis

Ohs

Potassium Sodium Disorder Of Erythrocyte

OHST

Stomatocytosis I

Potassium-Sodium Disorder Of Erythrocyte

Stomatocytosisiohst

Hereditary, Overhydrated, Cation-Leak Stomatocytosis

Overhydrated Cation Leak Stomatocytosis

Stomatocytosis, Overhydrated Hereditary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07518 LANCL1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus LANCL1 MGD MGI:1336997
Bos taurus LANCL1 VGNC VGNC:30783
Felis catus LANCL1 VGNC VGNC:68016
Macaca mulatta LANCL1 VGNC VGNC:104541
Canis familiaris LANCL1 VGNC VGNC:42580
Rattus norvegicus LANCL1 RGD RGD:69416
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