2. Gene
  3. AKR1A1 - aldo-keto reductase family 1 member A1 Gene

AKR1A1 - aldo-keto reductase family 1 member A1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：醛酮还原酶家族 1 成员 A1

种属: Homo sapiens

同用名: ALR; ARM; DD3; ALDR1; HEL-S-6

基因 ID: 10327 | 基因类型: protein coding

关于 AKR1A1

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:45,550,826-45,570,049 (from NCBI)

This gene has 14 transcripts (splice variants), 234 orthologues and 16 paralogues. Ubiquitous expression in kidney (RPKM 113.8), duodenum (RPKM 66.6) and 25 other tissues.

功能概要

该基因编码醛/酮还原酶超家族的一个成员，该家族由 40 多种已知的酶和蛋白质组成。该成员也称为醛还原酶，参与生物醛和外源醛的还原，几乎存在于每个组织中。该基因存在多个选择性剪接的转录物变体，所有变体都编码相同的蛋白质。[RefSeq 提供，2011 年 1 月]

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known Enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]

AKR1A1 基因产物(4)

mRNA Protein Name
NM_001202413.2 NP_001189342.1 aldo-keto reductase family 1 member A1
NM_001202414.2 NP_001189343.1 aldo-keto reductase family 1 member A1
NM_006066.4 NP_006057.1 aldo-keto reductase family 1 member A1
NM_153326.3 NP_697021.1 aldo-keto reductase family 1 member A1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L-glucuronate reductase activity EXP
EXP: 通过实验结果推断
7669785 GOA
enables L-glucuronate reductase activity IDA
IDA: 通过直接分析推断
10510318 GOA
enables glucuronolactone reductase activity IDA
IDA: 通过直接分析推断
10510318 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21044950 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in daunorubicin metabolic process IDA
IDA: 通过直接分析推断
18276838 GOA
involved in doxorubicin metabolic process IDA
IDA: 通过直接分析推断
18276838 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AKR1A1 蛋白结构

Aldo_ket_red

Aldo_ket_red: Aldo/keto reductase family (17 - 293)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
蛋白主名 其他名称

aldo-keto reductase family 1 member A1

HEL-S-165mP

AKR1A1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
AKR1A1 P14550 HTT Homo sapiens P42858
Validated Y2H
32814053
种属内
AKR1A1 P14550 HTT Homo sapiens P42858
Y2H Array
32814053
种属内
AKR1A1 P14550 HTT Homo sapiens P42858
Y2H Pooling
32814053
种属内
AKR1A1 P14550 WFS1 Homo sapiens O76024
Validated Y2H
32814053
种属内
AKR1A1 P14550 WFS1 Homo sapiens O76024
Y2H Array
32814053
种属内
AKR1A1 P14550 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属内
AKR1A1 P14550 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 AKR1A1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76137 AKR1A1 Protein, Human (His) P14550 (M1-Y325) ≥95%

关联疾病

疾病名称 别名
Fetal Alcohol Syndrome

Fetal Alcohol Spectrum Disorders

Arbd

Arnd

Alcohol-Related Birth Defects

Alcohol-Related Neurodevelopmental Disorder

Fas

Fasd

Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk

Alcohol Related Birth Defect

Alcohol Related Neurodevelopmental Disorder

Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk

Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk

Dysmorphism Due To Alcohol

Fetal Etoh Syndrome
Alcoholic Liver Cirrhosis

Alcoholic Cirrhosis

Portal Cirrhosis

Alcoholic Cirrhosis Of Liver

Liver Cirrhosis, Alcoholic

Laennec'S Cirrhosis

Laennec'S Cirrhosis, Alcoholic

Alcohol Cirrhosis

Alcoholic Laennec Cirrhosis

Alcoholic Cirrhosis Nos

Etoh Cirrhosis

Alcohol Hepatic Cirrhosis

Alcohol Liver Cirrhosis

Laennec Cirrhosis
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Liver Cirrhosis

Cirrhosis

Cirrhosis Of Liver

CIRRH

Cryptogenic Cirrhosis

Cirrhosis, Cryptogenic

Cirrhosis Nos
Metabolic Acidosis
Hypoascorbemia

Scurvy

Ascorbic Acid Deficiency

Vitamin C Deficiency

Vitamin C, Inability To Synthesize

Deficiency Of Vitamin C

Scorbutus

Vitamin C
Alcohol Use Disorder

Alcohol Abuse

Alcoholism

Ethanol Abuse

Alcohol Addiction

Alcohol Dependence

Alcoholic Intoxication, Chronic

Alcohol-Related Disorders
Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (17)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0376 Liquiritin 99.68% 否
HY-106697 Ponalrestat Inhibitor 99.51% 否
HY-D1341 Coumberone 99.95% 否
HY-150644 S07-2010 Inhibitor 99.79% 否
HY-114009 AKR1C1-IN-1 99.38% 否
HY-133708 β-Glucogallin Inhibitor 99.82% 否
HY-N8549A 5-Dihydrocortisone ≥99.0% 否
HY-113850 CPSA Inhibitor / 否
HY-149254 PTP1B/AKR1B1-IN-1 Inhibitor / 否
HY-149255 PTP1B/AKR1B1-IN-2 Inhibitor / 否
HY-163609 PROTAC AKR1C3 degrader-1 Degrader / 否
HY-N0376R Liquiritin (Standard) / 否
HY-RS00531 AKR1A1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00532 AKR1B1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00534 AKR1C1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00538 AKR1D1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-118819 5-Bromo-3-phenyl salicylic acid Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus AKR1A1 RGD RGD:68346
Bos taurus AKR1A1 VGNC VGNC:25795
Felis catus AKR1A1 VGNC VGNC:59723
Mus musculus AKR1A1 MGD MGI:1929955
Macaca mulatta AKR1A1 VGNC VGNC:106319
Canis familiaris AKR1A1 VGNC VGNC:37768
Others AKR1A1 NCBI
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