2. Gene
  3. Scrib - scribbled planar cell polarity Gene

Scrib - scribbled planar cell polarity Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Crc; CRIB; Scrb1; SCRIB1; vartul; mKIAA0147

基因 ID: 105782 | 基因类型: protein coding

关于 Scrib

功能概要

Involved in several processes, including establishment of T cell polarity; negative regulation of activated T cell proliferation; and synaptic vesicle cycle. Acts upstream of or within several processes, including nervous system development; post-anal tail morphogenesis; and wound healing. Located in several cellular components, including basolateral plasma membrane; immunological synapse; and myelin sheath abaxonal region. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; hair follicle; and nervous system. Orthologous to human SCRIB (scribble planar cell polarity protein). [provided by Alliance of Genome Resources, Apr 2022]

Scrib 基因产物(3)

mRNA Protein Name
NM_001310542.1 NP_001297471.1 protein scribble homolog isoform 2
NM_001310543.1 NP_001297472.1 protein scribble homolog isoform 3
NM_134089.2 NP_598850.1 protein scribble homolog isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16611247 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within auditory receptor cell morphogenesis IGI
IGI: 通过遗传相互作用推断
20215345 MGI
acts upstream of or within auditory receptor cell stereocilium organization IGI
IGI: 通过遗传相互作用推断
20215345 MGI
involved in cell migration IMP
IMP: 通过突变表型推断
18716323 MGI
acts upstream of or within cochlear nucleus development IGI
IGI: 通过遗传相互作用推断
20215345 MGI
involved in establishment of T cell polarity IDA
IDA: 通过直接分析推断
18329370 MGI
acts upstream of or within inner ear receptor cell stereocilium organization IMP
IMP: 通过突变表型推断
21515572 MGI
involved in mammary gland duct morphogenesis IMP
IMP: 通过突变表型推断
19041750 MGI
acts upstream of or within morphogenesis of embryonic epithelium IMP
IMP: 通过突变表型推断
12499390 MGI
involved in negative regulation of activated T cell proliferation IMP
IMP: 通过突变表型推断
18329370 MGI
acts upstream of or within neural tube closure IGI
IGI: 通过遗传相互作用推断
21515572 MGI
acts upstream of or within neural tube closure IMP
IMP: 通过突变表型推断
20643356 MGI
involved in positive chemotaxis IMP
IMP: 通过突变表型推断
18716323 MGI
involved in positive regulation of type II interferon production IMP
IMP: 通过突变表型推断
18329370 MGI
acts upstream of or within post-anal tail morphogenesis IGI
IGI: 通过遗传相互作用推断
21515572 MGI
acts upstream of or within post-anal tail morphogenesis IMP
IMP: 通过突变表型推断
21515572 MGI
acts upstream of or within protein localization IMP
IMP: 通过突变表型推断
16687519 MGI
involved in synaptic vesicle endocytosis IDA
IDA: 通过直接分析推断
19458197 MGI
involved in synaptic vesicle endocytosis IMP
IMP: 通过突变表型推断
19458197 MGI
involved in synaptic vesicle targeting IMP
IMP: 通过突变表型推断
19458197 MGI
acts upstream of or within wound healing IGI
IGI: 通过遗传相互作用推断
20643356 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
16687519 MGI
located in cell-cell contact zone IDA
IDA: 通过直接分析推断
22333836 MGI
located in immunological synapse IDA
IDA: 通过直接分析推断
18329370 MGI
located in myelin sheath abaxonal region IDA
IDA: 通过直接分析推断
20237282 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein scribble homolog

PDZ-domain protein scribble

circletail

scribble homolog 1

scribbled homolog

Scrib 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Scrib Q80U72 Crtam Mus musculus Q149L7
Confocal
18329370
种属间
Scrib Q80U72 PHLPP1 Homo sapiens O60346
Anti Tag CoIP
21701506
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12562 SCRIB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Scrib NCBI NCBI:23513
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