1. Gene
  2. PARK7 - Parkinsonism associated deglycase Gene

PARK7 - Parkinsonism associated deglycase Gene

中文名称:帕金森病相关去糖酶

种属: Homo sapiens

同用名: DJ1; DJ-1; GATD2; HEL-S-67p

基因 ID: 11315 | 基因类型: protein coding

关于 PARK7

Cytogenetic location: 1p36.23 Genomic coordinates (GRCh38): 1:7,961,711-7,985,505 (from NCBI)

This gene has 10 transcripts (splice variants), 216 orthologues and is associated with 3 phenotypes. Ubiquitous expression in adrenal (RPKM 125.5), thyroid (RPKM 111.2) and 25 other tissues.

功能概要

该基因的产物属于肽酶 C56 蛋白家族。它作为雄激素受体依赖性转录的正调节剂。它也可以作为氧化还原敏感的伴侣,作为氧化应激的传感器,并且它显然可以保护神经元免受氧化应激和细胞死亡。该基因的缺陷是常染色体隐性遗传性早发性帕金森病 7 的原因。已为该基因鉴定出编码相同蛋白质的两个转录变体。[RefSeq 提供,2008 年 7 月]

The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

PARK7 基因产物(2)

mRNA Protein Name
NM_001123377.2 NP_001116849.1 Parkinson disease protein 7
NM_007262.5 NP_009193.2 Parkinson disease protein 7
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
15790595 GOA
enables L-dopa decarboxylase activator activity IDA
IDA: 通过直接分析推断
19703902 GOA
enables copper ion binding IDA
IDA: 通过直接分析推断
23792957 GOA
enables cupric ion binding IDA
IDA: 通过直接分析推断
24567322 GOA
enables cuprous ion binding IDA
IDA: 通过直接分析推断
24144264 GOA
enables cytokine binding IPI
IPI: 通过物理相互作用推断
21097510 GOA
NOT enables double-stranded DNA binding IDA
IDA: 通过直接分析推断
22683601 GOA
enables enzyme activator activity IDA
IDA: 通过直接分析推断
23743200 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
19703902 GOA
enables glyoxalase (glycolic acid-forming) activity IDA
IDA: 通过直接分析推断
31653696 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15502874 GOA
enables kinase binding IPI
IPI: 通过物理相互作用推断
19229105 GOA
enables mRNA binding IDA
IDA: 通过直接分析推断
18626009 GOA
enables mercury ion binding IDA
IDA: 通过直接分析推断
23792957 GOA
enables nuclear androgen receptor binding IPI
IPI: 通过物理相互作用推断
17510388 GOA
enables oxidoreductase activity, acting on peroxide as acceptor IDA
IDA: 通过直接分析推断
24567322 GOA
enables peptidase activity IDA
IDA: 通过直接分析推断
20304780 GOA
enables peptidase inhibitor activity IDA
IDA: 通过直接分析推断
21097510 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11477070 GOA
NOT enables protein deglycase activity IDA
IDA: 通过直接分析推断
31653696 GOA
enables protein deglycase activity IDA
IDA: 通过直接分析推断
25416785 GOA
enables protein deglycase activity IMP
IMP: 通过突变表型推断
26995087 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
18711745 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
24144264 GOA
enables scaffold protein binding IPI
IPI: 通过物理相互作用推断
21785459 GOA
enables signaling receptor activator activity IDA
IDA: 通过直接分析推断
17510388 GOA
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
21785459 GOA
NOT enables single-stranded DNA binding IDA
IDA: 通过直接分析推断
22683601 GOA
enables small protein activating enzyme binding IPI
IPI: 通过物理相互作用推断
15983381 GOA
enables superoxide dismutase copper chaperone activity IDA
IDA: 通过直接分析推断
24567322 GOA
enables transcription coactivator activity IGI
IGI: 通过遗传相互作用推断
15790595 GOA
enables tyrosine 3-monooxygenase activator activity IDA
IDA: 通过直接分析推断
19703902 GOA
enables ubiquitin-like protein conjugating enzyme binding IPI
IPI: 通过物理相互作用推断
15983381 GOA
enables ubiquitin-protein transferase inhibitor activity IDA
IDA: 通过直接分析推断
24899725 GOA
enables ubiquitin-specific protease binding IPI
IPI: 通过物理相互作用推断
21097510 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA repair IDA
IDA: 通过直接分析推断
28596309 GOA
involved in androgen receptor signaling pathway IMP
IMP: 通过突变表型推断
17510388 GOA
involved in cellular detoxification of aldehyde IDA
IDA: 通过直接分析推断
28993701 GOA
involved in cellular detoxification of methylglyoxal IDA
IDA: 通过直接分析推断
28993701 GOA
involved in cellular response to glyoxal IDA
IDA: 通过直接分析推断
22523093 GOA
involved in cellular response to hydrogen peroxide IMP
IMP: 通过突变表型推断
22492997 GOA
involved in cellular response to oxidative stress IDA
IDA: 通过直接分析推断
15983381 GOA
involved in cellular response to oxidative stress IMP
IMP: 通过突变表型推断
24899725 GOA
involved in detoxification of copper ion IMP
IMP: 通过突变表型推断
23792957 GOA
involved in detoxification of hydrogen peroxide IDA
IDA: 通过直接分析推断
14749723 GOA
involved in glycolate biosynthetic process IDA
IDA: 通过直接分析推断
22523093 GOA
involved in glyoxal metabolic process IDA
IDA: 通过直接分析推断
22523093 GOA
involved in guanine deglycation IDA
IDA: 通过直接分析推断
28596309 GOA
involved in guanine deglycation, glyoxal removal IDA
IDA: 通过直接分析推断
28596309 GOA
involved in guanine deglycation, methylglyoxal removal IDA
IDA: 通过直接分析推断
28596309 GOA
involved in hydrogen peroxide metabolic process IDA
IDA: 通过直接分析推断
24567322 GOA
involved in lactate biosynthetic process IDA
IDA: 通过直接分析推断
22523093 GOA
involved in methylglyoxal catabolic process to lactate IDA
IDA: 通过直接分析推断
28993701 GOA
NOT involved in methylglyoxal metabolic process IDA
IDA: 通过直接分析推断
27903648 GOA
involved in methylglyoxal metabolic process IDA
IDA: 通过直接分析推断
22523093 GOA
involved in negative regulation of TRAIL-activated apoptotic signaling pathway IMP
IMP: 通过突变表型推断
21785459 GOA
involved in negative regulation of death-inducing signaling complex assembly IMP
IMP: 通过突变表型推断
21785459 GOA
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
14652021 GOA
involved in negative regulation of extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
21785459 GOA
involved in negative regulation of gene expression IDA
IDA: 通过直接分析推断
22683601 GOA
involved in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
14652021 GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide IDA
IDA: 通过直接分析推断
24947010 GOA
involved in negative regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
22511790 GOA
involved in negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
14752510 GOA
acts upstream of negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
22523093 GOA
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
15790595 GOA
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
23743200 GOA
acts upstream of negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
17015834 GOA
involved in negative regulation of protein K48-linked deubiquitination IDA
IDA: 通过直接分析推断
21097510 GOA
involved in negative regulation of protein acetylation IDA
IDA: 通过直接分析推断
22683601 GOA
involved in negative regulation of protein export from nucleus IGI
IGI: 通过遗传相互作用推断
15983381 GOA
involved in negative regulation of protein phosphorylation IGI
IGI: 通过遗传相互作用推断
15983381 GOA
involved in negative regulation of protein sumoylation IDA
IDA: 通过直接分析推断
16731528 GOA
acts upstream of negative regulation of protein ubiquitination IDA
IDA: 通过直接分析推断
17015834 GOA
involved in negative regulation of protein ubiquitination IDA
IDA: 通过直接分析推断
24899725 GOA
acts upstream of positive regulation of L-dopa biosynthetic process IMP
IMP: 通过突变表型推断
16731528 GOA
involved in positive regulation of dopamine biosynthetic process IDA
IDA: 通过直接分析推断
19703902 GOA
acts upstream of positive regulation of interleukin-8 production IDA
IDA: 通过直接分析推断
21097510 GOA
involved in positive regulation of mitochondrial electron transport, NADH to ubiquinone IMP
IMP: 通过突变表型推断
19822128 GOA
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
22492997 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
22492997 GOA
involved in positive regulation of protein localization to nucleus IDA
IDA: 通过直接分析推断
21097510 GOA
involved in positive regulation of protein localization to nucleus IMP
IMP: 通过突变表型推断
22492997 GOA
involved in positive regulation of protein-containing complex assembly IDA
IDA: 通过直接分析推断
24947010 GOA
involved in positive regulation of reactive oxygen species metabolic process IDA
IDA: 通过直接分析推断
20969476 GOA
acts upstream of positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
21097510 GOA
acts upstream of positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
17015834 GOA
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15790595 GOA
acts upstream of positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16731528 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
22492997 GOA
involved in protein repair IDA
IDA: 通过直接分析推断
25416785 GOA
involved in protein stabilization IDA
IDA: 通过直接分析推断
24947010 GOA
acts upstream of protein stabilization IMP
IMP: 通过突变表型推断
17015834 GOA
involved in protein stabilization IMP
IMP: 通过突变表型推断
17015834 GOA
NOT involved in regulation of TRAIL production IMP
IMP: 通过突变表型推断
21785459 GOA
involved in regulation of androgen receptor signaling pathway IDA
IDA: 通过直接分析推断
11477070 GOA
involved in regulation of mitochondrial membrane potential IMP
IMP: 通过突变表型推断
23743200 GOA
involved in regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
18711745 GOA
involved in regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
15983381 GOA
involved in removal of superoxide radicals IDA
IDA: 通过直接分析推断
24567322 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in PML body IDA
IDA: 通过直接分析推断
22683601 GOA
located in chromatin IDA
IDA: 通过直接分析推断
16731528 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
12446870 GOA
located in cytosol IDA
IDA: 通过直接分析推断
14662519 GOA
located in cytosol IMP
IMP: 通过突变表型推断
21785459 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
31536960 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
15790595 GOA
located in mitochondrion IMP
IMP: 通过突变表型推断
21785459 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11477070 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
25468996 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PARK7 蛋白结构

DJ-1_PfpI

DJ-1_PfpI: DJ-1/PfpI family (32 - 173)

  • 0
  • 100
  • 189 a.a.
蛋白主名 其他名称

Parkinson disease protein 7

Parkinson disease (autosomal recessive, early onset) 7

PARK7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PARK7 Q99497 KRTAP9-2 Homo sapiens Q9BYQ4 32814053
种属内
PARK7 Q99497 KRTAP9-2 Homo sapiens Q9BYQ4 32814053
种属内
PARK7 Q99497 KRTAP9-2 Homo sapiens Q9BYQ4 32814053
种属内
PARK7 Q99497 OTUB1 Homo sapiens Q96FW1 32814053
种属内
PARK7 Q99497 OTUB1 Homo sapiens Q96FW1 32814053
种属内
PARK7 Q99497 OTUB1 Homo sapiens Q96FW1 32814053
种属内
PARK7 Q99497 FYN Homo sapiens P06241-3 32814053
种属内
PARK7 Q99497 FYN Homo sapiens P06241-3 32814053
种属内
PARK7 Q99497 FYN Homo sapiens P06241-3 32814053
种属内
PARK7 Q99497 DNM2 Homo sapiens P50570-2 32814053
种属内
PARK7 Q99497 DNM2 Homo sapiens P50570-2 32814053
种属内
PARK7 Q99497 DNM2 Homo sapiens P50570-2 32814053
种属内
PARK7 Q99497 AP2B1 Homo sapiens P63010-2 32814053
种属内
PARK7 Q99497 AP2B1 Homo sapiens P63010-2 32814053
种属内
PARK7 Q99497 AP2B1 Homo sapiens P63010-2 32814053
种属内
PARK7 Q99497 DAXX Homo sapiens Q9UER7 32814053
种属内
PARK7 Q99497 BBS1 Homo sapiens Q8NFJ9 32814053
种属内
PARK7 Q99497 FADD Homo sapiens Q13158 21785459
种属内
PARK7 Q99497 BBS1 Homo sapiens Q8NFJ9 32814053
种属内
PARK7 Q99497 PARK7 Homo sapiens Q99497 15502874
种属内
PARK7 Q99497 BBS1 Homo sapiens Q8NFJ9 32814053
种属内
PARK7 Q99497 DAXX Homo sapiens Q9UER7 32814053
种属内
PARK7 Q99497 DAXX Homo sapiens Q9UER7 15983381
种属内
PARK7 Q99497 DAXX Homo sapiens Q9UER7
Y2H
15983381
种属内
PARK7 Q99497 DAXX Homo sapiens Q9UER7 32814053
种属内
PARK7 Q99497 DAXX Homo sapiens Q9UER7
IF
15983381
种属内
PARK7 Q99497 PARK7 Homo sapiens Q99497
Y2H
15983381
种属内
PARK7 Q99497 PARK7 Homo sapiens Q99497 24947010
种属内
PARK7 Q99497 MTA2 Homo sapiens O94776 20127688
种属内
PARK7 Q99497 MTA2 Homo sapiens O94776 20127688
种属内
PARK7 Q99497 RNF111 Homo sapiens Q6ZNA4-2 32814053
种属内
PARK7 Q99497 RNF111 Homo sapiens Q6ZNA4-2 32814053
种属内
PARK7 Q99497 RNF111 Homo sapiens Q6ZNA4-2 32814053
种属内
PARK7 Q99497 TOR1A Homo sapiens O14656-2 32814053
种属内
PARK7 Q99497 TOR1A Homo sapiens O14656-2 32814053
种属内
PARK7 Q99497 TOR1A Homo sapiens O14656-2 32814053
种属内
PARK7 Q99497 CAMKK1 Homo sapiens Q8N5S9-2 32814053
种属内
PARK7 Q99497 CAMKK1 Homo sapiens Q8N5S9-2 32814053
种属内
PARK7 Q99497 CAMKK1 Homo sapiens Q8N5S9-2 32814053
种属内
PARK7 Q99497 RACK1 Homo sapiens P63244 24947010
种属内
PARK7 Q99497 RACK1 Homo sapiens P63244
TAP
24947010
种属内
PARK7 Q99497 RACK1 Homo sapiens P63244 24947010
种属内
PARK7 Q99497 GOPC Homo sapiens Q9HD26 25416956
种属内
PARK7 Q99497 GOPC Homo sapiens Q9HD26 25416956
种属内
PARK7 Q99497 SKIC8 Homo sapiens Q9GZS3 32814053
种属内
PARK7 Q99497 SKIC8 Homo sapiens Q9GZS3 32814053
种属内
PARK7 Q99497 SKIC8 Homo sapiens Q9GZS3 32814053
种属内
PARK7 Q99497 FADD Homo sapiens Q13158 21785459
种属内
PARK7 Q99497 OTUD7B Homo sapiens Q6GQQ9 21097510
种属内
PARK7 Q99497 OTUD7B Homo sapiens Q6GQQ9 21097510
种属内
PARK7 Q99497 AR Homo sapiens P10275
Y2H
17510388
种属内
PARK7 Q99497 AR Homo sapiens P10275 17510388
种属内
PARK7 Q99497 AR Homo sapiens P10275 17510388
种属内
PARK7 Q99497 A2M Homo sapiens P01023 32814053
种属内
PARK7 Q99497 A2M Homo sapiens P01023 32814053
种属内
PARK7 Q99497 A2M Homo sapiens P01023 32814053
种属内
PARK7 Q99497 PYCR1 Homo sapiens P32322 23743200
种属内
PARK7 Q99497 PYCR1 Homo sapiens P32322 23743200
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PARK7 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71625 PARK7/DJ-1 Protein, Human (GST) Q99497 (1M-188K) ≥95%
HY-P74653 PARK7/DJ-1 Protein, Human (His) Q99497 (M1-D189) ≥95%

PARK7 抗体

目录号 产品名 应用 反应物种
HY-P82054 PARK7/DJ1 Antibody (YA1799) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Parkinson Disease 7, Autosomal Recessive Early-Onset

Autosomal Recessive Early-Onset Parkinson Disease 7

PARK7

Parkinson'S Disease 7

Autosomal Recessive Early-Onset Parkinson'S Disease 7

Parkinson Disease 7

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Type 2

Autosomal Recessive Early-Onset Parkinson Disease Type 7

Parkinson Disease, Type 7

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1

Guam Disease

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Of Guam

Als-Pdc

Lytico-Bodig Disease

Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1, Susceptibility To

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex, Susceptibility To

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex

Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Of Guam Syndrome

Parkinsonism-Dementia-Als Complex

Pdals

Amyotrophic Lateral Sclerosis, Parkinsonism/Dementia Complex Of Guam

Parkinson-Dementia Complex Of Guam

G-Pdc

Guam Parkinsonism-Dementia Complex

ALS-PDC1

Als/Pdc Of Guam

Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic/Parkinsonism/Dementia Complex 1

Amyotrophic Lateral Sclerosis, Guam Form

Parkinsonian Disorders

Parkinson Disease 6, Autosomal Recessive Early-Onset

Autosomal Recessive Early-Onset Parkinson Disease 6

Parkinson Disease 6

PARK6

Parkinson Disease 6, Early Onset

Parkinson'S Disease 6

Parkinson Disease 6, Early-Onset

Autosomal Recessive Early-Onset Parkinson'S Disease 6

Early-Onset Parkinson Disease 6

Autosomal Recessive Early-Onset Parkinson Disease Type 6

Parkinson Disease 6 Early-Onset

Parkinson Disease 6 Late-Onset Susceptibility To

Parkinson Disease Autosomal Recessive Early-Onset Digenic Pink1/Dj1

Parkinsonism Young Adult Onset

Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1

Parkinson Disease, Type 6, Autosomal Recessive, Early-Onset

Parkinson Disease 2, Autosomal Recessive Juvenile

Young-Onset Parkinson Disease

PARK2

Pdj

Autosomal Recessive Juvenile Parkinson Disease 2

Epdf

Parkinson Disease, Juvenile, Type 2

Parkinson'S Disease 2

Autosomal Recessive Juvenile Parkinson Disease

Early-Onset Parkinson Disease

Parkinson Disease 2

Parkinson Disease, Juvenile, Autosomal Recessive

Parkinsonism, Early-Onset, With Diurnal Fluctuation

Autosomal Recessive Juvenile Parkinson'S Disease 2

Jp

Juvenile Parkinsonism

Parkinson Disease Autosomal Recessive, Early Onset

Parkinsonism, Early Onset, With Diurnal Fluctuation

Yopd

Autosomal Recessive Early-Onset Parkinson Disease Type 2

Chromosome 6-Linked Autosomal Recessive Parkinsonism

Early-Onset Parkinsonism With Diurnal Fluctuation

Parkinsonism Young Adult Onset

Parkinson Disease, Type 2

Parkinsonism, Juvenile

Parkinsonism

Parkinsonism-Plus

Idiopathic Parkinsonism

Primary Parkinsonism

Paralysis Agitans Syndrome

Parkinsonian Syndrome

Trembling Paralysis

Paralysis Agitans

Shaking Palsy

Shaking Paralysis

Parkinson Disease 3, Autosomal Dominant

PARK3

Parkinson Disease 3

Parkinson Disease 3, Autosomal Dominant Lewy Body

Parkinson'S Disease 3

Autosomal Dominant Lewy Body Parkinson Disease 3

Autosomal Dominant Parkinson Disease 3

Parkinson Disease Type 3

Autosomal Dominant Parkinson Disease

Parkinson Disease, Autosomal Dominant

Parkinson Disease, Familial, Type 1

Dementia

Dementias

Presenile Dementia

Alzheimer Type Dementia

Alzheimer Sclerosis

Alzheimer Disease Dementia

Alzheimer Dementia

Primary Degenerative Alzheimer Type Dementia

End Stage Alzheimer'S Dementia

Alzheimer'S Type Atypical Dementia

Alzheimer Type Presenile Dementia

Early Onset Alzheimer Dementia

Dementia In Alzheimer Disease Type 2

Dementia In Alzheimer Disease With Early Onset

Early Onset Alzheimer Type Dementia, Uncomplicated

Primary Degenerative Alzheimer Type Dementia, Early Onset

Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated

Alzheimer Disease Dementia With Early Onset

Presenile Sclerosis

Presenile Brain Sclerosis

Presenile Alzheimer Brain Sclerosis

Late Onset Alzheimer Dementia

Dementia In Alzheimer Disease Type 1

Dementia In Alzheimer Disease With Late Onset

Primary Degenerative Alzheimer Type Dementia, Late Onset

Sdat - [Senile Dementia, Alzheimer Type]

Alzheimer Disease Dementia With Late Onset

Late Onset Alzheimer Brain Sclerosis

Senile Alzheimer Brain Disease

Senile Alzheimer Brain Sclerosis

Senile Primary Degenerative Alzheimer Type Dementia

Senile Dementia Of The Alzheimer Type

Arteriosclerotic Dementia

Strategic-Infarct Dementia

Post Stroke Dementia

Vascular Cognitive Impairment

Vascular Dementia

Dementia Of The Lewy Body Type

Dementia With Lewy Bodies

Sdlt - [Senile Dementia Of The Lewy Body Type]

Senile Dementia Of The Lewy Body Type

Alcohol-Related Dementia

Alcoholic Dementia Nos

Alcohol-Induced Dementia

Alcoholic Brain Syndrome

Chronic Alcoholic Brain Syndrome

Alcohol Dementia

Late Onset Alcoholic Psychosis

Residual And Late-Onset Alcohol-Induced Psychotic Disorder

Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder

Late-Onset Psychoactive Substance-Induced Psychotic Disorder

Inhalant Dementia

Volatile Solvents Dementia

Dementia In Paralysis Agitans

Pdd - [Parkinson Disease Dementia]

Dementia Syndrome Of Parkinson Disease

Dementia In Parkinson Disease

Parkinson Related Dementia

Dementia In Huntington Chorea

Hiv - [Human Immunodeficiency Virus] Dementia

Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex

Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex

Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex

Aids Related Dementia

Dementia Due To Niacin Deficiency

Glottis Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Glottis

Squamous Cell Carcinoma Of Glottis

Anterior Dislocation Of Lens
Movement Disease

Movement Disorders

Movement Disorder

Early-Onset Parkinson'S Disease

Early-Onset Parkinson Disease

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Dementia, Lewy Body

Lewy Body Dementia

Lewy Body Disease

Diffuse Lewy Body Disease

Dementia With Lewy Bodies

DLB

Autosomal Dominant Diffuse Lewy Body Disease

Cortical Lewy Body Disease

Dementia, Lewy Body, Susceptibility To

Lewy Body Dementia, Susceptibility To

Senile Dementia Of The Lewy Body Type

Dementia Of The Lewy Body Type

Lbd

Diffuse Lewy Body Disease With Gaze Palsy

Dysphasic Dementia Hereditary

Lewy Body Type Senile Dementia

Lewy Body Variant Of Alzheimer Disease

Lewy Bodies

Lewy Body

Dlbd - [Diffuse Lewy Body Disease]

Clbd - [Cortical Lewy Body Disease]

Supranuclear Palsy, Progressive, 1

Progressive Supranuclear Palsy

Steele-Richardson-Olszewski Syndrome

Supranuclear Palsy, Progressive

Progressive Supranuclear Ophthalmoplegia

Psp

PSNP1

Familial Progressive Supranuclear Palsy

Richardson'S Syndrome

Psp Syndrome

Progressive Supranuclear Palsy 1

Supranuclear Palsy Progressive

Ophthalmoplegia, Supranuclear, Progressive

Steele-Richardson-Olszewksi Syndrome

Postencephalitic Parkinson Disease

Postencephalitic Parkinsonism

Parkinson Disease, Postencephalitic

Kufor-Rakeb Syndrome

Park9

Krppd

KRS

Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis And Dementia

Autosomal Recessive Parkinson Disease 9

Parkinson Disease 9

Parkinson Disease 9, Autosomal Recessive, Juvenile-Onset

Autosomal Recessive Juvenile Onset Parkinson Disease 9

Parkinson Disease Type 9

Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis, And Dementia

Park 9

Atp13a2-Related Juvenile Neuronal Ceroid Lipofuscinosis

Cln12 Disease

Juvenile Parkinsonism-Neuronal Ceroid Lipofuscinosis

Parkinson Disease Autosomal Recessive 9

Parkinson Disease 15, Autosomal Recessive Early-Onset

Parkinsonian-Pyramidal Syndrome

Pallidopyramidal Syndrome

Parkinson Disease 15, Autosomal Recessive

PARK15

Pkps

Pallido-Pyramidal Syndrome

Parkinson'S Disease 15

Autosomal Recessive Early-Onset Parkinson Disease 15

Autosomal Recessive Early-Onset Parkinson'S Disease 15

Pallido-Pyramidal Disease

Parkinson Disease 15

Parkinson Disease 15 Autosomal Recessive

Pps

Parkinson Disease, Type 15

Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility

Polyneuropathy

Polyneuropathies

Vascular Parkinsonism
Dystonia 12

DYT12

Rdp

Generalized Dystonia

Dystonia-12

Rapid-Onset Dystonia-Parkinsonism

Familial Dystonia

Dystonia Musculorum Deformans

Dystonic Disorders

Idiopathic Familial Dystonia

Dystonia-Parkinsonism, Rapid-Onset

Fragments Of Torsion Dystonia

Dyt-Atp1a3

Rapid-Onset Dystonia Parkinsonism

Rodp

Dystonia, Type 12

Dystonia 3, Torsion, X-Linked

Idiopathic Non-Familial Dystonia

Symptomatic Torsion Dystonia

Dystonia Disorders

Rem Sleep Behavior Disorder

Rapid Eye Movement Sleep Behavior Disorder

Rem Sleep Behaviour Disorder

Rapid Eye Movement Sleep Behaviour Disorder

Rem - [Rapid Eye Movement] Behaviour Disorder

Alzheimer Disease 2

AD2

Alzheimer Disease Associated With Apoe4

Alzheimer'S Disease 2

Alzheimer Disease-2

Alzheimer Disease 2, Late-Onset

Alzheimer Disease 2, Late Onset

Late-Onset Alzheimer Disease

Alzheimer Disease, Type 2

Alzheimer Disease, Late Onset

Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia

Multiple System Atrophy 1

Multiple System Atrophy

Shy-Drager Syndrome

Msa

MSA1

Multiple System Atrophy 1, Susceptibility To

Sporadic Olivopontocerebellar Atrophy

Multisystem Atrophy

Msa1, Susceptibility To

Multiple System Atrophy, Susceptibility To

Opca

Progressive Autonomic Failure With Multiple System Atrophy

Sds

Parkinson Disease 17

PARK17

Parkinson'S Disease 17

Autosomal Dominant Parkinson Disease 17

Parkinson Disease, Type 17

Gaucher Disease, Type I

Glucocerebrosidase Deficiency

Acid Beta-Glucosidase Deficiency

Gba Deficiency

GD1

Gd I

Gaucher Disease, Noncerebral Juvenile

Gaucher Disease Type 1

Gaucher Disease Type I

Gaucher'S Disease Type I

Gaucher Disease

Gd 1

Non-Cerebral Juvenile Gaucher Disease

GD

Gaucher Disease 1

Adult Non-Neuronopathic Gaucher Disease

Noncerebral Juvenile Gaucher Disease

Type 1 Gaucher Disease

Gaucher Disease, Type 1

Meier-Gorlin Syndrome 3

MGORS3

Meier-Gorlin Syndrome, Type 3

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Gaucher'S Disease

Gaucher Disease

Kerasin Thesaurismosis

Glucocerebrosidase Deficiency

Glucosylceramidase Deficiency

Cerebroside Lipidosis Syndrome

Acid Beta-Glucosidase Deficiency

Glucosylceramide Beta-Glucosidase Deficiency

Acute Cerebral Gaucher Disease

Gaucher Splenomegaly

Glucocerebrosidosis

Glucosyl Cerebroside Lipidosis

Kerasin Lipoidosis

Lipoid Histiocytosis

Glocucerebrosidase Deficiency

Sphingolipidosis 1

Gaucher Syndrome

Gauchers Disease

Gd

Glucosylceramide Lipidosis

Kerasin Histiocytosis

Gaucher Disease, Type 1

Gaucher Disease, Type 2

Toxic Encephalopathy

Neurotoxicity

Neurotoxicity Syndromes

Neurotoxicity Syndrome

Encephalopathy, Toxic

Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

Choreatic Disease

Chorea

Hereditary Chorea

Bardet-Biedl Syndrome

Bbs

Biedl-Bardet Syndrome

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency

Nadh:Q(1) Oxidoreductase Deficiency

MC1DN1

Nadh-Coenzyme Q Reductase Deficiency

Isolated Mitochondrial Respiratory Chain Complex I Deficiency

Isolated Nadh-Coenzyme Q Reductase Deficiency

Isolated Nadh-Coq Reductase Deficiency

Isolated Nadh-Ubiquinone Reductase Deficiency

Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of

Nuclear Type Mitochondrial Complex I Deficiency 1

Isolated Complex I Deficiency

Complex 1 Mitochondrial Respiratory Chain Deficiency

Nadh Coenzyme Q Reductase Deficiency

Complex I Mitochondrial Respiratory Chain Deficiency

Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I

Nadh:Ubiquinone Oxidoreductase Deficiency

Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Pick Disease Of Brain

Pick Disease

Pick'S Disease

Pick Disease Of The Brain

Lobar Atrophy Of Brain

Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions

Behavioral Variant Of Frontotemporal Dementia

Dementia In Pick'S Disease

Lobar Atrophy Of The Brain

Bvftd

Bv-Ftd

PIDB

Picks Disease

Hemochromatosis, Type 1

Hemochromatosis

Hemochromatosis Type 1

Hereditary Hemochromatosis

Hh

HFE1

Hfe Hemochromatosis, Modifier Of

Symptomatic Form Of Classic Hemochromatosis

Symptomatic Form Of Hemochromatosis Type 1

Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

Haemochromatosis

Iron Storage Disorder

Bronze Diabetes

Hereditary Haemochromatosis

Hlah

Hfe

Hemochromatosis, Hereditary

Diabetes Bronze

Classic Hemochromatosis

Hfe-Associated Hereditary Hemochromatosis

Hemochromatosis Classic

Bronzed Cirrhosis

Familial Hemochromatosis

Genetic Hemochromatosis

Hc

Pigmentary Cirrhosis

Primary Hemochromatosis

Troisier-Hanot-Chauffard Syndrome

Von Recklenhausen-Applebaum Disease

Hemochromatosis 1

Primary Hereditary Hemochromatosis

Bronze Cirrhosis

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias

Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Peripheral Nervous System Disease

Peripheral Neuropathy

Peripheral Nerve Disease

Peripheral Nerve Disorders

Neuropathy, Peripheral

Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PARK7 VGNC VGNC:44266
Rattus norvegicus PARK7 RGD RGD:621808
Macaca mulatta PARK7 VGNC VGNC:106466
Bos taurus PARK7 VGNC VGNC:32586
Mus musculus PARK7 MGD MGI:2135637
Felis catus PARK7 VGNC VGNC:64042
Others PARK7 NCBI