2. Gene
  3. CGAS - cyclic GMP-AMP synthase Gene

CGAS - cyclic GMP-AMP synthase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：环状 GMP-AMP 合酶

种属: Homo sapiens

同用名: MB21D1; h-cGAS; C6orf150

基因 ID: 115004 | 基因类型: protein coding

关于 CGAS

Cytogenetic location: 6q13 Genomic coordinates (GRCh38): 6:73,423,711-73,452,297 (from NCBI)

This gene has 4 transcripts (splice variants), 185 orthologues and 9 paralogues.

功能概要

启用多项功能，包括 2',3'-环状 GMP-AMP 合酶活性；染色质结合活性；和 phosphatidylinositol-4,5-bisphosphate 结合活性。参与多个过程，包括对外源 dsRNA 的细胞反应；细胞内信号转导的正向调节；和防御反应的监管。位于多种细胞成分中，包括胞质溶胶；核;和双链断裂部位。[基因组资源联盟提供，2022年4月]

Enables several functions, including 2',3'-cyclic GMP-AMP synthase activity; chromatin binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including cellular response to exogenous dsRNA; positive regulation of intracellular signal transduction; and regulation of defense response. Located in several cellular components, including cytosol; nucleus; and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]

CGAS 基因产物(3)

mRNA Protein Name
NM_138441.3 NP_612450.2 cyclic GMP-AMP synthase isoform 1
XM_047418159.1 XP_047274115.1 cyclic GMP-AMP synthase isoform X1
NM_001410911.1 NP_001397840.1 cyclic GMP-AMP synthase isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 2',3'-cyclic GMP-AMP synthase activity EXP
EXP: 通过实验结果推断
23258412 GOA
enables 2',3'-cyclic GMP-AMP synthase activity IDA
IDA: 通过直接分析推断
23258413 GOA
enables DNA binding IDA
IDA: 通过直接分析推断
23258413 GOA
enables chromatin binding IDA
IDA: 通过直接分析推断
28738408 GOA
enables double-stranded DNA binding IDA
IDA: 通过直接分析推断
24077100 GOA
enables molecular condensate scaffold activity IDA
IDA: 通过直接分析推断
32911482 GOA
enables nucleosome binding IDA
IDA: 通过直接分析推断
32911482 GOA
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: 通过直接分析推断
30827685 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
26046437 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
29426904 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
28738408 GOA
involved in activation of innate immune response IDA
IDA: 通过直接分析推断
23258413 GOA
involved in activation of innate immune response IMP
IMP: 通过突变表型推断
23258413 GOA
involved in cAMP-mediated signaling IDA
IDA: 通过直接分析推断
23258413 GOA
involved in cGAS/STING signaling pathway IDA
IDA: 通过直接分析推断
32911482 GOA
involved in cGMP-mediated signaling IDA
IDA: 通过直接分析推断
23258413 GOA
involved in cytoplasmic pattern recognition receptor signaling pathway IDA
IDA: 通过直接分析推断
23258413 GOA
involved in defense response to virus IDA
IDA: 通过直接分析推断
21478870 GOA
involved in innate immune response IDA
IDA: 通过直接分析推断
23258413 GOA
involved in negative regulation of cGAS/STING signaling pathway IDA
IDA: 通过直接分析推断
32911482 GOA
involved in negative regulation of double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
30356214 GOA
involved in paracrine signaling IDA
IDA: 通过直接分析推断
24077100 GOA
involved in pattern recognition receptor signaling pathway IDA
IDA: 通过直接分析推断
23258413 GOA
involved in positive regulation of defense response to virus by host IDA
IDA: 通过直接分析推断
23929945 GOA
involved in positive regulation of defense response to virus by host IMP
IMP: 通过突变表型推断
23258413 GOA
involved in positive regulation of type I interferon production IDA
IDA: 通过直接分析推断
24077100 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
23258413 GOA
is active in cytosol IDA
IDA: 通过直接分析推断
32912999 GOA
located in cytosol IDA
IDA: 通过直接分析推断
23258413 GOA
is active in nucleus IDA
IDA: 通过直接分析推断
38418882 GOA
located in nucleus IDA
IDA: 通过直接分析推断
29937271 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
30827685 GOA
located in site of double-strand break IDA
IDA: 通过直接分析推断
30356214 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CGAS 蛋白结构

Mab-21

Mab-21: Mab-21 protein (213 - 510)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 522 a.a.
蛋白主名 其他名称

cyclic GMP-AMP synthase

2'3'-cGAMP synthase

Mab-21 domain containing 1

cGAMP synthase

mab-21 domain-containing protein 1

protein MB21D1

重组 CGAS 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71597 cGAS Protein, Human (His-SUMO) Q8N884-1 (G161-F522) ≥95%
HY-P72337 cGAS Protein, Human (His) Q8N884-1 (M1-F522) ≥95%

关联疾病

疾病名称 别名
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Encephalopathy With Basal Ganglia Calcification

Aicardi-Goutières Syndrome

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1
Covid-19

2019 Novel Coronavirus

2019-Ncov Infection

Covid19

Sars-Cov-2 Infection

Wuhan Coronavirus Infection

Wuhan Seafood Market Pneumonia Virus Infection
Chilblain Lupus 1

Chilblain Lupus

CHBL1

Chilblain Lupus Erythematosus

Chle

Hutchinson Lupus

Chilblain Lupus, Type 1
Sting-Associated Vasculopathy With Onset In Infancy

Savi

Sting-Associated Vasculopathy, Infantile Onset

Sting-Associated Vasculopathy, Infantile-Onset
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever
Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations

Crv

Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations

Rvcl

Rvcl-S

Vasculopathy, Retinal, With Cerebral Leukodystrophy

Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena

Retinal Vasculopathy With Cerebral Leukodystrophy

Retinal Vasculopathy And Cerebral Leukoencephalopathy

Hereditary Vascular Retinopathy

Hvr

RVCLS

Cerebroretinal Vasculopathy, Hereditary

Cerebroretinal Vasculopathy

Herns

Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly

Hereditary Cerebroretinal Vasculopathy

Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke

Hereditary Systemic Angiopathy

Hsa

Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations

Adrvcl

Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy

Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke

Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Cutaneous Lupus Erythematosus

Lupus Erythematosus, Cutaneous

Lupus Erythematosus Cutaneous
Huntington Disease

Huntington'S Disease

Huntington Chorea

HD

Huntington'S Chorea

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea
Severe Covid-19
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-160406 SNX281 Agonist 99.08% Phase 1
Pre-clinical Phase
生物活性分子 (53)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-114180 RU.521 Inhibitor 99.95% 否
HY-131454 SR-717 Agonist 99.89% 否
HY-133916 G140 Inhibitor 98.11% 否
HY-128583 G150 Inhibitor 99.12% 否
HY-150751 ODN TTAGGG Antagonist 99.87% 否
HY-114182 PF-06928215 Inhibitor 99.69% 否
HY-139056 SU0268 Inhibitor 99.96% 否
HY-W021040 Fludioxonil 99.94% 否
HY-123230 Trifloxystrobin Inhibitor 99.49% 否
HY-114181 IRAK4-IN-4 Inhibitor 99.85% 否
HY-150751C ODN TTAGGG sodium Antagonist 99.87% 否
HY-149526 cGAS-IN-1 Inhibitor 98.29% 否
HY-160546 cGAS-IN-2 Inhibitor 99.67% 否
HY-B1331 Cyromazine 99.79% 否
HY-138646 Poly(deoxyadenylic-thymidylic) acid sodium Activator / 否
HY-158045 PROTAC PARP1 degrader-1 Inhibitor 99.86% 否
HY-164288 TDI-6570 Inhibitor 99.64% 否
HY-131454A SR-717 free acid Agonist 98.05% 否
HY-118578 Furalaxyl Inhibitor / 否
HY-123230R Trifloxystrobin (Standard) Inhibitor / 否
HY-123230S Trifloxystrobin-d6 Inhibitor / 否
HY-13735H Quinacrine acetate / 否
HY-144328 STING agonist-10 Activator / 否
HY-144329 STING agonist-11 Activator / 否
HY-150751A Biotin-labeled ODN TTAGGG sodium / 否
HY-150751B FITC-labeled ODN TTAGGG sodium Antagonist / 否
HY-158126 G-quadruplex ligand 2 Inhibitor / 否
HY-159925 QKY-613 Activator / 否
HY-162133 MSA-2-Pt Agonist / 否
HY-162459 cGAS-IN-3 Inhibitor / 否
HY-162944 NA-Ir / 否
HY-162966 MS7829 Degrader / 否
HY-162967 MS8588 / 否
HY-163461 4F-DDC Inhibitor / 否
HY-B0621S1 Triclabendazole-13C,d3 Inhibitor / 否
HY-N12507 Eupenicisirenin C Inhibitor / 否
HY-P3041 Chromostatin (bovine) Inhibitor / 否
HY-RS02575 CGA Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02576 CGAS Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02577 Cgas Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02578 Cgas Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-114730 CGA-JK3 Inhibitor / 否
HY-12464 Butafenacil / 否
HY-132221 CU-32 Inhibitor / 否
HY-79128S1 Fmoc-L-Lys (Boc)-OH-13C6,15N2 Inhibitor / 否
HY-79648S Fmoc-Methylalanine-d3 / 否
HY-N15159 Cladophorol A Inhibitor / 否
HY-W010319S 2-Amino-4-methoxy-6-methyl-1,3,5-triazine-d3 / 否
HY-W020788 Benoxacor Agonist 99.39% 否
HY-W289054S (S)-Metolachlor metabolite CGA 50720-d3 / 否
HY-W714168S (rac)-Metolachlor metabolite CGA 351916-d3 / 否
HY-W714705S (S)-Metolachlor metabolite CGA 368208-d3 sodium salt / 否
HY-W722289S (rac)-Metolachlor metabolite CGA 50267-d3 / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CGAS VGNC VGNC:43047
Rattus norvegicus CGAS RGD RGD:1586939
Bos taurus CGAS VGNC VGNC:31271
Felis catus CGAS VGNC VGNC:60830
Macaca mulatta CGAS VGNC VGNC:71069
Mus musculus CGAS MGD MGI:2442261
Others CGAS NCBI
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