Keap1 - Kelch-like ECH-associated protein 1 Gene

中文名称：Kelch 样 ECH 相关蛋白 1

种属: Rattus norvegicus

同用名: Inrf2

关于 Keap1

功能概要

预计该基因编码的蛋白能够实现无序的结构域特异性结合活性和相同的蛋白质结合活性。参与多个过程，包括基因表达的调节；对甲状腺激素的反应；和硒的复合代谢过程。位于多个细胞成分中，包括粘附连接；粘着斑；和核。部分含蛋白质复合物。糖尿病视网膜病变的生物标志物；晚期肾脏疾病;和输尿管梗阻。该基因的人类直系同源物与胆囊癌有关。与人类 KEAP1 同源（kelch 样 ECH 相关蛋白 1）。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable disordered domain specific binding activity and identical protein binding activity. Involved in several processes, including regulation of gene expression; response to thyroid hormone; and selenium compound metabolic process. Located in several cellular components, including adherens junction; focal adhesion; and nucleus. Part of protein-containing complex. Biomarker of diabetic retinopathy; end stage renal disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in gallbladder Cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]