2. Gene
  3. Keap1 - Kelch-like ECH-associated protein 1 Gene

Keap1 - Kelch-like ECH-associated protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：Kelch 样 ECH 相关蛋白 1

种属: Rattus norvegicus

同用名: Inrf2

基因 ID: 117519 | 基因类型: protein coding

关于 Keap1

Primary_assembly 8: 19,768,375-19,777,862 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 189 orthologues, 53 paralogues and is associated with 28 phenotypes. Biased expression in Muscle (RPKM 121.2), Adrenal (RPKM 18.2) and 9 other tissues.

功能概要

预计该基因编码的蛋白能够实现无序的结构域特异性结合活性和相同的蛋白质结合活性。参与多个过程，包括基因表达的调节；对甲状腺激素的反应；和硒的复合代谢过程。位于多个细胞成分中，包括粘附连接；粘着斑；和核。部分含蛋白质复合物。糖尿病视网膜病变的生物标志物；晚期肾脏疾病;和输尿管梗阻。该基因的人类直系同源物与胆囊癌有关。与人类 KEAP1 同源（kelch 样 ECH 相关蛋白 1）。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable disordered domain specific binding activity and identical protein binding activity. Involved in several processes, including regulation of gene expression; response to thyroid hormone; and selenium compound metabolic process. Located in several cellular components, including adherens junction; focal adhesion; and nucleus. Part of protein-containing complex. Biomarker of diabetic retinopathy; end stage renal disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in gallbladder Cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Keap1 基因产物(1)

mRNA Protein Name
NM_057152.2 NP_476493.2 kelch-like ECH-associated protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11439354 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to carbohydrate stimulus IDA
IDA: 通过直接分析推断
20026152 RGD
involved in cellular response to organic cyclic compound IEP
IEP: 通过表达模式推断
11439354 RGD
involved in cytoplasmic sequestering of transcription factor IMP
IMP: 通过突变表型推断
11439354 RGD
involved in negative regulation of gene expression IDA
IDA: 通过直接分析推断
20026152 RGD
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
11439354 RGD
involved in response to immobilization stress IEP
IEP: 通过表达模式推断
17316384 RGD
involved in response to metal ion IEP
IEP: 通过表达模式推断
22649286 RGD
involved in response to thyroid hormone IEP
IEP: 通过表达模式推断
22649286 RGD
involved in selenium compound metabolic process IEP
IEP: 通过表达模式推断
16978024 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in adherens junction IDA
IDA: 通过直接分析推断
14506708 RGD
located in focal adhesion IDA
IDA: 通过直接分析推断
14506708 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
20026152 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Keap1 蛋白结构

BTB_POZ_KLHL19_KEAP1

BTB_POZ_KLHL19_KEAP1: cd18248 (55 - 179)

PHA03098

PHA03098: cl33709 (94 - 598)

Kelch

Kelch: sd00038 (361 - 408)

Kelch

Kelch: sd00038 (412 - 455)

Kelch

Kelch: sd00038 (459 - 502)

Kelch

Kelch: sd00038 (506 - 550)

Kelch

Kelch: sd00038 (553 - 596)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 624 a.a.
蛋白主名 其他名称

kelch-like ECH-associated protein 1

cytosolic inhibitor of Nrf2

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-N0005 Curcumin 98.84% Phase 4
HY-13755 Sulforaphane 99.75% Phase 4
Pre-clinical Phase
生物活性分子 (68)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100218A RSL3 99.90% 否
HY-112675 4-Octyl itaconate Activator 99.98% 否
HY-19543 Brusatol 99.89% 否
HY-101140 KI696 Inhibitor 99.26% 否
HY-110258 ML334 Activator 99.76% 否
HY-134205A CBR-470-1 Activator 98.03% 否
HY-111126 K67 Activator 98.43% 否
HY-145879 Nrf2 activator-2 Activator 98.92% 否
HY-13755A (R)-Sulforaphane 99.48% 否
HY-120371 CPUY192018 Inhibitor 98.99% 否
HY-W009731 Dibenzoylmethane Activator ≥98.0% 否
HY-110275 RA839 98.90% 否
HY-131592 Tricetin 99.19% 否
HY-139047 SW157765 Inhibitor 98.67% 否
HY-149508 Nrf2-IN-3 Inhibitor 99.19% 否
HY-B0854 Mancozeb / 否
HY-101140A KI696 isomer Inhibitor 99.32% 否
HY-P1328 TAT-14 Activator 99.66% 否
HY-100218C (1R,3R)-RSL3 99.52% 否
HY-122054A BPK-29 hydrochloride Inhibitor 98.28% 否
HY-149010 NXPZ-2 Inhibitor 98.18% 否
HY-150579 Keap1-Nrf2-IN-13 Inhibitor 96.77% 否
HY-110258B (R,S,R)-ML334 98.57% 否
HY-139620A MS83 epimer 1 98.36% 否
HY-122054 BPK-29 Inhibitor 99.4% 否
HY-121523 MIND4-17 Activator 99.93% 否
HY-139620 MS83 Chemical / 否
HY-147517 Keap1-Nrf2-IN-9 Inhibitor 98.52% 否
HY-151362 Keap1-Nrf2-IN-14 Inhibitor / 否
HY-162152 biKEAP1 Inhibitor / 否
HY-RS07230 KEAP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-112675S 4-Octyl itaconate-13C5-1 / 否
HY-124834 Nrf2 activator-10 / 否
HY-124941 7-Deacetylgedunin Activator / 否
HY-139862 Keap1-Nrf2-IN-3 Inhibitor / 否
HY-141439 TBE 31 Activator / 否
HY-143892 Keap1-Nrf2-IN-5 Inhibitor / 否
HY-143893 Keap1-Nrf2-IN-6 Inhibitor / 否
HY-144099 Keap1-Nrf2-IN-4 / 否
HY-146577 Keap1-Nrf2-IN-7 Inhibitor / 否
HY-146578 Keap1-Nrf2-IN-8 Inhibitor / 否
HY-147548 Keap1-Nrf2-IN-10 Inducer / 否
HY-147924 Keap1-Nrf2-IN-11 Inhibitor / 否
HY-149245 Keap1-Nrf2-IN-15 Inhibitor / 否
HY-150578 Keap1-Nrf2-IN-12 Inhibitor / 否
HY-155997 Anti-inflammatory agent 56 Inhibitor / 否
HY-156065 S217879 Activator / 否
HY-157928 Keap1-Nrf2-IN-18 Inhibitor / 否
HY-157929 Keap1-Nrf2-IN-19 Inhibitor / 否
HY-159495 Keap1-Nrf2-IN-21 / 否
HY-160876 BC-1901S Activator / 否
HY-161643 S21-1011 / 否
HY-168065 Keap1-Nrf2-IN-22 Inhibitor / 否
HY-168161 Keap1-Nrf2-IN-23 Inhibitor / 否
HY-168526 Keap1-Nrf2-IN-24 Inhibitor / 否
HY-168640 RIP3 activator 1 / 否
HY-169315 Nrf2 activator 17 Activator / 否
HY-N10313 Dehydrobruceine B / 否
HY-N8160 Dehydrocurdione / 否
HY-P10530 Nrf2 (69-84) / 否
HY-P1328A TAT-14 TFA Activator / 否
HY-P5480 Keap1-Nrf2-IN-16 / 否
HY-P5909 Keap1-Nrf2 probe / 否
HY-P5909F FITC-labelled Keap1-Nrf2 probe / 否
HY-RS07231 Keap1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS07232 Keap1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-162096 Keap1-Nrf2-IN-17 Inhibitor / 否
HY-W505984 TPNA10168 Activator / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Keap1 NCBI NCBI:9817
Mus musculus Keap1 NCBI NCBI:50868
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