2. Gene
  3. DCC - DCC netrin 1 receptor Gene

DCC - DCC netrin 1 receptor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：DCC netrin 1 受体

种属: Homo sapiens

同用名: CRC18; CRCR1; MRMV1; HGPPS2; IGDCC1; NTN1R1

基因 ID: 1630 | 基因类型: protein coding

关于 DCC

Cytogenetic location: 18q21.2 Genomic coordinates (GRCh38): 18:52,340,197-53,535,899 (from NCBI)

This gene has 18 transcripts (splice variants), 193 orthologues, 36 paralogues and is associated with 109 phenotypes. Biased expression in testis (RPKM 2.4), brain (RPKM 1.4) and 2 other tissues.

功能概要

该基因编码 netrin 1 受体。跨膜蛋白是细胞粘附分子免疫球蛋白超家族的成员，介导神经元生长锥的轴突导向 netrin 1 配体来源。细胞质尾部与酪氨酸激酶 Src 和粘着斑激酶 (FAK，也称为 PTK2) 相互作用以介导轴突吸引。该蛋白部分定位于脂筏，并在没有配体的情况下诱导细胞凋亡。该蛋白作为肿瘤抑制因子发挥作用，在结直肠癌和食道癌中经常发生突变或下调。[RefSeq 提供，2009 年 10 月]

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces Apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal Cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]

DCC 基因产物(1)

mRNA Protein Name
NM_005215.4 NP_005206.2 netrin receptor DCC

DCC 蛋白结构

Ig_2

Ig_2: Immunoglobulin domain (44 - 136)

I-set

I-set: Immunoglobulin I-set domain (141 - 222)

I-set

I-set: Immunoglobulin I-set domain (241 - 327)

I-set

I-set: Immunoglobulin I-set domain (333 - 417)

fn3

fn3: Fibronectin type III domain (430 - 514)

fn3

fn3: Fibronectin type III domain (530 - 607)

fn3

fn3: Fibronectin type III domain (625 - 708)

fn3

fn3: Fibronectin type III domain (727 - 806)

fn3

fn3: Fibronectin type III domain (846 - 931)

fn3

fn3: Fibronectin type III domain (946 - 1034)

Neogenin_C

Neogenin_C: Neogenin C-terminus (1146 - 1445)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1447 a.a.
蛋白主名 其他名称

netrin receptor DCC

colorectal cancer suppressor

重组 DCC 蛋白

目录号 产品名 蛋白编号 纯度
HY-P78745 Netrin receptor DCC/DCC Protein, Human (HEK293, His) P43146-1 (F32-N1097) ≥95%

关联疾病

疾病名称 别名
Mirror Movements 1

Congenital Mirror Movement Disorder

Bimanual Synergia

Congenital Mirror Movements

Familial Congenital Controlateral Synkinesia

Familial Congenital Mirror Movements

Hereditary Congenital Controlateral Synkinesia

Hereditary Congenital Mirror Movements

Isolated Congenital Controlateral Synkinesia

Isolated Congenital Mirror Movements

Mirror Movements

MRMV1

Mirror Movements 1 And/Or Agenesis Of The Corpus Callosum

Mirror Movements, Congenital

Bimanual Synkinesis

Cmm

Mirror Movements, Type 1
Gaze Palsy, Familial Horizontal, With Progressive Scoliosis 2, With Impaired Intellectual Development

Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2

HGPPS2

Developmental Split-Brain Syndrome

Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2, With Impaired Intellectual Development
Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Gaze Palsy, Familial Horizontal, With Progressive Scoliosis 1

Hgpps

Horizontal Gaze Palsy With Progressive Scoliosis

Gaze Palsy, Familial Horizontal, With Progressive Scoliosis

HGPPS1

Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 1

Gaze Palsy, Horizontal, With Progressive Scoliosis

Progressive External Ophthalmoplegia And Scoliosis

Familial Horizontal Gaze Palsy With Progressive Scoliosis

Familial Idiopathic Scoliosis Associated With Congenital Encephalopathy

Familial Infantile Scoliosis Associated With Bilateral Paralysis Of Conjugate Gaze

Ophthalmoplegia, Progressive External, And Scoliosis

Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, Type 1
Corpus Callosum, Agenesis Of

Corpus Callosum Agenesis

Agenesis Of The Corpus Callosum

Isolated Corpus Callosum Agenesis

Acc

Non Rare In Europe: Isolated Corpus Callosum Agenesis

Congenital Malformation Of Corpus Callosum

Deformity Of Corpus Callosum

Absence Of Corpus Callosum

Absent Corpus Callosum

Acc - [Agenesis Of Corpus Callosum]

Aplasia Of Corpus Callosum

Congenital Absence Of Corpus Callosum

Hypoplastic Corpus Callosum

Hypoplasia Of Corpus Callosum
Intellectual Disability - Hypoplastic Corpus Callosum - Preauricular Tag

Da Silva Syndrome

Intellectual Disability-Hypoplastic Corpus Callosum-Preauricular Tag Syndrome
Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia
Corpus Callosum, Partial Agenesis Of, X-Linked

X-Linked Complicated Corpus Callosum Dysgenesis

Corpus Callosum, Partial Agenesis Of

Partial Agenesis Of The Corpus Callosum

Partial Agenesis Of Corpus Callosum

Agenesis Of The Corpus Callosum, X-Linked, Partial

ACCPX

Agenesis, Corpus Callosum, Partial
Non-Syndromic X-Linked Intellectual Disability Arx-Related

Arx-Related Intellectual Disability

Mrxarx

X-Linked Mental Retardation 29

X-Linked Mental Retardation 29 And Others

X-Linked Mental Retardation 32

X-Linked Mental Retardation 33

X-Linked Mental Retardation 38

X-Linked Mental Retardation 43

X-Linked Mental Retardation 76

X-Linked Mental Retardation 87

X-Linked Mental Retardation With Or Without Seizures Arx-Related

Mental Retardation, X-Linked, Type 29 And Others
Scoliosis
Gastric Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Stomach

Squamous Cell Carcinoma Of The Stomach
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-112306 Ripretinib 99.33% 是
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-136256 Vimseltinib Inhibitor 99.08% Phase 3
HY-13024 Rebastinib 99.91% Phase 2
HY-B0791 Altiratinib Inhibitor 98.05% Phase 1
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-Y1092 N,N-Dicyclohexylcarbodiimide(DCC) 99.75% 否
HY-160699 DCC-3116 Inhibitor 99.25% 否
HY-100855 DC_C66 Inhibitor / 否
HY-117074 BMS-247243 / 否
HY-157262 Methyl isonicotinate-(CH2)2-COOH / 否
HY-163008 Dicamba-5-aminopentanoic acid / 否
HY-RS03571 DCC Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus DCC VGNC VGNC:61363
Mus musculus DCC MGD MGI:94869
Canis familiaris DCC VGNC VGNC:39799
Macaca mulatta DCC VGNC VGNC:71746
Bos taurus DCC VGNC VGNC:109406
Rattus norvegicus DCC RGD RGD:2492
Others DCC NCBI
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