RPL5 - ribosomal protein L5 Gene

中文名称：核糖体蛋白 L5

种属: Homo sapiens

同用名: L5; uL18; MSTP030; PPP1R135

基因 ID: 6125 | 基因类型: protein coding

关于 RPL5

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:92,831,986-92,841,924 (from NCBI)

This gene has 11 transcripts (splice variants), 226 orthologues and is associated with 59 phenotypes. Ubiquitous expression in ovary (RPKM 1433.7), thyroid (RPKM 620.7) and 25 other tissues.

功能概要

核糖体是催化蛋白质合成的细胞器，由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由四种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码核糖体蛋白 L18P 家族的成员和 60S 亚基的组成部分。编码的蛋白质结合 5S rRNA 形成称为 5S 核糖核蛋白颗粒 (RNP) 的稳定复合物，这是将非核糖体相关的细胞质 5S rRNA 运输到核仁以组装成核糖体所必需的。编码的蛋白质还可以通过激活下游肿瘤抑制因子和下调癌蛋白表达来抑制肿瘤发生。已在 Diamond-Blackfan 贫血 (DBA) 患者中发现该基因的突变。该基因与位于其第五个内含子的小核仁 RNA 基因 U21 共同转录。对于编码核糖体蛋白的基因来说，这是典型的，该基因有多个经过处理的假基因分散在整个基因组中。[RefSeq 提供，2017 年 3 月]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18P family of ribosomal proteins and component of the 60S subunit. The encoded protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The encoded protein may also function to inhibit tumorigenesis through the activation of downstream tumor suppressors and the downregulation of oncoprotein expression. Mutations in this gene have been identified in patients with Diamond-Blackfan Anemia (DBA). This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Mar 2017]

RPL5 基因产物(1)

mRNA	Protein	Name
NM_000969.5	NP_000960.2	60S ribosomal protein L5

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 5S rRNA binding	IDA IDA: 通过直接分析推断	18560357	GOA
enables mRNA 3'-UTR binding	IDA IDA: 通过直接分析推断	16213212	GOA
enables mRNA 5'-UTR binding	IDA IDA: 通过直接分析推断	16213212	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9465063	GOA
enables structural constituent of ribosome	IDA IDA: 通过直接分析推断	23636399	GOA
enables structural constituent of ribosome	IMP IMP: 通过突变表型推断	18697920	GOA
enables ubiquitin ligase inhibitor activity	IDA IDA: 通过直接分析推断	18560357	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	18560357	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of protein neddylation	IDA IDA: 通过直接分析推断	18560357	GOA
involved in negative regulation of ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	18560357	GOA
involved in negative regulation of ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	18560357	GOA
involved in positive regulation of gene expression	IDA IDA: 通过直接分析推断	18560357	GOA
involved in positive regulation of translation	IDA IDA: 通过直接分析推断	16213212	GOA
involved in protein stabilization	IMP IMP: 通过突变表型推断	18560357	GOA
involved in rRNA processing	IMP IMP: 通过突变表型推断	18697920	GOA
involved in regulation of signal transduction by p53 class mediator	IMP IMP: 通过突变表型推断	24120868	GOA
involved in ribosomal large subunit assembly	IMP IMP: 通过突变表型推断	24120868	GOA
involved in ribosomal large subunit biogenesis	IMP IMP: 通过突变表型推断	18697920	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	15314173	GOA
part of cytosolic large ribosomal subunit	IDA IDA: 通过直接分析推断	32669547	GOA
part of cytosolic large ribosomal subunit	IPI IPI: 通过物理相互作用推断	25901680	GOA
located in cytosolic ribosome	IDA IDA: 通过直接分析推断	23636399	GOA
located in nucleolus	IDA IDA: 通过直接分析推断	15469983	GOA
located in nucleoplasm	IDA IDA: 通过直接分析推断	24120868	GOA
located in nucleus	IDA IDA: 通过直接分析推断	9687515	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	15314173	GOA
part of ribonucleoprotein complex	IDA IDA: 通过直接分析推断	18809582	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPL5 蛋白结构

Ribosomal_L18p

Ribosomal_L18_c

0
100
200
297 a.a.

蛋白主名

其他名称

60S ribosomal protein L5

large ribosomal subunit protein uL18

RPL5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RPL5	P46777	RPS23	Homo sapiens	P62266	Anti Tag CoIP	35271311
种属内	RPL5	P46777	RPS23	Homo sapiens	P62266	Density Sedimentation	20434207
种属内	RPL5	P46777	RPL23	Homo sapiens	P62829	Anti Tag CoIP	35271311
种属内	RPL5	P46777	RPL23	Homo sapiens	P62829	Crosslink	30021884
种属内	RPL5	P46777	RRP1B	Homo sapiens	Q14684	Anti Tag CoIP	35271311
种属内	RPL5	P46777	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	17110929
种属内	RPL5	P46777	SURF2	Homo sapiens	Q15527	Y2H	21900206
种属内	RPL5	P46777	SURF2	Homo sapiens	Q15527	Anti Tag CoIP	35271311
种属间	RPL5	P46777	Dcc	Rattus norvegicus	Q63155	Anti Bait CoIP	20434207
种属间	RPL5	P46777	Dcc	Rattus norvegicus	Q63155	Confocal	20434207

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Diamond-Blackfan Anemia 6

DBA6	Aase-Smith Syndrome Ii
Aase Syndrome	Aase Smith Syndrome 2
Rpl5-Related Diamond-Blackfan Anemia	Anemia, Diamond-Blackfan, Type 6
Diamond-Blackfan Anemia 1

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Atrial Heart Septal Defect

Atrial Septal Defect	Atrial Septal Defects
Atrioseptal Defect	Auricular Septal Defect
Congenital Atrial Septal Defect	Interatrial Septal Defect
Interauricular Septal Defect	Heart Septal Defects, Atrial
Septal Defect, Atrial

Diamond-Blackfan Anemia 1

Aase Syndrome	DBA1
Erythrogenesis Imperfecta	Aase-Smith Syndrome Ii
Dba	Blackfan-Diamond Syndrome
Bds	Anemia, Congenital Hypoplastic, Of Blackfan And Diamond
Anemia, Congenital Erythroid Hypoplastic	Red Cell Aplasia, Pure, Hereditary
Aregenerative Anemia, Chronic Congenital	Rps19-Related Diamond-Blackfan Anemia
Chronic Congenital Aregenerative Anemia	Congenital Erythroid Hypoplastic Anemia
Congenital Hypoplastic Anemia Of Blackfan And Diamond	Pure Hereditary Red Cell Aplasia
Anemia, Diamond-Blackfan, Type 1	Anemia, Diamond-Blackfan
Aase Smith Syndrome 2	Familial Hypoplastic Anaemia With Malformations
Constitutional Pure Red Cell Aplasia

Hemangioma

Hemangiomas

Interatrial Communication

Asd	Atrial Septal Defect
Interauricular Communication

Aplastic Anemia

Aplastic Anemia, Susceptibility To	Anemia Aplastic
Idiopathic Aplastic Anemia	Secondary Aplastic Anemia
Idiopathic Bone Marrow Failure	Aplastic Anemia Idiopathic
AA	Anemia, Aplastic
Aplastic Anemia, Idiopathic	Erythroid Aplasia
Aa - [Aplastic Anaemia]	Haematopoietic Aplasia
Aleukia Haemorrhagica	Anaemia Due To Decreased Red Cell Production
Aplasia Bone Marrow	Aplastic Bone Marrow
Hypoplastic Anaemia Nos	Myeloid Bone Marrow Aplasia
Pancytopenia	Panhaematopenia
Hypoproliferative Anaemia	Medullary Hypoplasia
Red Blood Cells Hypoplastic Anaemia	Panmyelophthisis
Panhemocytopenia	Refractive Hypoproliferative Anaemia
Toxic Anaemia	Toxic Aplastic Anaemia
Aplastic Anaemia Due To Toxic Cause	Idiopathic Aplastic Anaemia Nos

Pulmonary Hypertension, Primary, 1

Pulmonary Arterial Hypertension	Pah
Idiopathic Pulmonary Arterial Hypertension	Idiopathic Pulmonary Hypertension
Primary Pulmonary Hypertension	PPH1
Pulmonary Hypertension, Primary, Fenfluramine Or Dexfenfluramine-Associated	Pulmonary Hypertension, Familial Primary, 1, With Or Without Hht
Pph	Familial Primary Pulmonary Hypertension
Sporadic Primary Pulmonary Hypertension	Pht
Fpah	Familial Pulmonary Arterial Hypertension
Hereditary Pulmonary Arterial Hypertension	Heritable Pulmonary Arterial Hypertension
Ayerza Syndrome	Fpph
Ppht	Ipah
Primary Pulmonary Arterial Hypertension	Pulmonary Hypertension, Familial Primary
Hypertension, Pulmonary, Primary, Type 1	Ayerza'S Syndrome
Pah - [Pulmonary Arterial Hypertension]	Arrillaga Ayerza Syndrome

Macrocytic Anemia

Anemia Macrocytic	Anemia, Macrocytic
Macrocytic Anaemia

Shwachman-Diamond Syndrome 1

Shwachman-Diamond Syndrome	Shwachman Syndrome
Shwachman-Bodian-Diamond Syndrome	Sds
Pancreatic Insufficiency And Bone Marrow Dysfunction	Shwachman-Bodian Syndrome
SDS1	Lipomatosis Of Pancreas, Congenital
Congenital Lipomatosis Of Pancreas	Shwachman-Diamond Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia, Shwachman Type	Shwachman-Diamond-Oski Syndrome

Dyskeratosis Congenita, X-Linked

DKCX	X-Linked Dyskeratosis Congenita
Zinsser-Cole-Engman Syndrome	Hoyeraal-Hreidarsson Syndrome
Dyskeratosis Congenita X-Linked	HHS
Cerebellar Hypoplasia With Pancytopenia	Prenatal Growth Retardation With Progressive Pancytopenia And Cerebellar Hypoplasia
Dyskeratosis Congenita

Bowen-Conradi Syndrome

BWCNS	Bowen Hutterite Syndrome
Bowen-Conradi Hutterite Syndrome	Bowen Syndrome, Hutterite Type
Bowen Hutterite Syndrome, Formerly	Hutterite Syndrome
Bowen Syndrome Hutterite Type	Fetal Growth Retardation

Pure Red-Cell Aplasia

Pure Red Cell Aplasia	Primary Red Cell Aplasia
Red Cell Hypoplasia	Prca
Red-Cell Aplasia Pure	Red-Cell Aplasia, Pure

Treacher Collins Syndrome 1

Treacher Collins Syndrome	Mandibulofacial Dysostosis
Treacher Collins-Franceschetti Syndrome	Tcof
Tcs	Mfd1
Franceschetti-Klein Syndrome	TCS1
Franceschetti Syndrome	Franceschetti-Zwahlen-Klein Syndrome
Zygoauromandibular Dysplasia	Treacher-Collins Syndrome
Mandibulofacial Dysostosis Without Limb Anomalies	Bilateral And Symmetric Oto-Mandibular Dysplasia

Anauxetic Dysplasia 1

Anauxetic Dysplasia	Spondylometaepiphyseal Dysplasia, Menger Type
Spondylometaepiphyseal Dysplasia, Anauxetic Type	Spondyloepimetaphyseal Dysplasia, Anauxetic Type
ANXD1	Anxd
Spondylometaepiphyseal Dysplasia Anauxetic Type	Spondylometaepiphyseal Dysplasia Menger Type
Ad	Spondyloepimetaphyseal Dysplasia, Menger Type
Dysplasia, Anauxetic, Type 1

Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type	CHH
Mckusick Type Metaphyseal Chondrodysplasia	Metaphyseal Dysplasia Without Hypotrichosis
Cartilage Hair Hypoplasia Like Syndrome	Metaphyseal Chondrodysplasia Mckusick Type
Chhv	Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only
Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency	Cartilage-Hair Syndrome
Mckusick'S Metaphyseal Chondrodysplasia Syndrome	Metaphyseal Chondrodysplasia, Recessive Type
Autosomal Recessive Metaphyseal Chondrodysplasia

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant	Dc
Dkc	Zinsser-Engman-Cole Syndrome
Dyskeratosis Congenita, Autosomal Dominant	Autosomal Dominant Dyskeratosis Congenita
Dkca	Dyskeratosis Congenita Scoggins Type
Zinsser-Cole-Engman Syndrome	X-Linked Dyskeratosis Congenita
Hoyeraal-Hreidarsson Syndrome

Orofacial Cleft

Cleft, Orofacial

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12201	RPL5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	RPL5	VGNC	VGNC:54064
Rattus norvegicus	RPL5	RGD	RGD:619825
Macaca mulatta	RPL5	VGNC	VGNC:100065
Mus musculus	RPL5	MGD	MGI:102854

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RPL5 - ribosomal protein L5 Gene

关于 RPL5

功能概要

RPL5 基因产物(1)

RPL5 蛋白结构

RPL5 蛋白互作信息

关联疾病

直系同源

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RPL5 - ribosomal protein L5 Gene

关于 RPL5

功能概要

RPL5 基因产物(1)

RPL5 蛋白结构

RPL5 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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F

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Q

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