Jun - jun proto-oncogene Gene

中文名称：Jun 原癌基因

种属: Mus musculus

同用名: AP-1; Junc; c-jun

关于 Jun

功能概要

该基因编码的蛋白可启动染色质结合活性和转录顺式调节区结合活性。参与细胞对茴香霉素的反应和从参与细胞对化学刺激反应的 RNA 聚合酶 II 启动子转录的正调控。作用于多个过程的上游或内部，包括动物器官发育；蛋白质自身磷酸化的负调节；和细胞群增殖的正调节。位于核内。转录抑制复合物的一部分。以多种结构表达，包括消化系统；中枢神经系统;泌尿生殖系统；长骨;和感觉器官。用于研究肺气肿。该基因的人类直系同源物与肺结核有关。与人类 JUN 同源（Jun 原癌基因，AP-1 转录因子亚基）。 [由基因组资源联盟提供，2022 年 4 月]

Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in cellular response to anisomycin and positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus. Acts upstream of or within several processes, including animal organ development; negative regulation of protein autophosphorylation; and positive regulation of cell population proliferation. Located in nucleus. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; long bone; and sensory organ. Used to study pulmonary emphysema. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human JUN (Jun proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]