Jun - Jun proto-oncogene, AP-1 transcription factor subunit Gene

中文名称：Jun 原癌基因，AP-1 转录因子亚单位

种属: Rattus norvegicus

基因 ID: 24516 | 基因类型: protein coding

关于 Jun

Primary_assembly 5: 109,893,145-109,897,656 reverse strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 226 orthologues, 1 paralogue and is associated with 40 phenotypes.

功能概要

该基因编码的蛋白可启动多种功能，包括 DNA 结合活性； DNA 结合转录激活剂活性，RNA 聚合酶 II 特异性；和 HMG 框域绑定活动。参与多个过程，包括细胞对钾离子饥饿的反应；大分子生物合成过程的正调控；和单核细胞分化的正调控。位于细胞质和细胞核中。部分含蛋白质复合物。与染色质共定位。用于研究高血压。精神抑郁症和肾癌的生物标志物。该基因的人类直系同源物与肺结核有关。与人类 JUN 同源（Jun 原癌基因，AP-1 转录因子亚基）。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and HMG box domain binding activity. Involved in several processes, including cellular response to potassium ion starvation; positive regulation of macromolecule biosynthetic process; and positive regulation of monocyte differentiation. Located in cytosol and nucleus. Part of protein-containing complex. Colocalizes with chromatin. Used to study hypertension. Biomarker of mental depression and renal carcinoma. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human JUN (Jun proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Jun 基因产物(1)

mRNA	Protein	Name
NM_021835.3	NP_068607.1	transcription factor Jun

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: 通过突变表型推断	17428807	RGD
enables DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	10830307	RGD
enables HMG box domain binding	IPI IPI: 通过物理相互作用推断	16582099	RGD
enables double-stranded DNA binding	IDA IDA: 通过直接分析推断	10830307	RGD
enables identical protein binding	IPI IPI: 通过物理相互作用推断	9369238	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	14610205	RGD
enables protein-containing complex binding	IPI IPI: 通过物理相互作用推断	9369238	RGD
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	10830307	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA-templated transcription	IDA IDA: 通过直接分析推断	16582099	RGD
involved in angiogenesis	IMP IMP: 通过突变表型推断	15126605	RGD
involved in cellular response to hypoxia	IEP IEP: 通过表达模式推断	8593588	RGD
involved in cellular response to potassium ion starvation	IMP IMP: 通过突变表型推断	17428807	RGD
involved in cellular response to prolactin	IEP IEP: 通过表达模式推断	8584023	RGD
involved in cellular response to zinc ion starvation	IEP IEP: 通过表达模式推断	21893222	RGD
involved in circadian rhythm	IEP IEP: 通过表达模式推断	10987819	RGD
involved in learning	IMP IMP: 通过突变表型推断	7948848	RGD
involved in membrane depolarization	IDA IDA: 通过直接分析推断	11571252	RGD
involved in positive regulation of DNA replication	IMP IMP: 通过突变表型推断	9487126	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	16582099	RGD
involved in positive regulation of apoptotic process	IMP IMP: 通过突变表型推断	12441106	RGD
involved in positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	15609298	RGD
involved in positive regulation of miRNA transcription	IDA IDA: 通过直接分析推断	18384814	RGD
involved in positive regulation of monocyte differentiation	IDA IDA: 通过直接分析推断	7947389	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: 通过突变表型推断	12514131	RGD
involved in positive regulation of smooth muscle cell proliferation	IDA IDA: 通过直接分析推断	11571252	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	19255142	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	17428807	RGD
involved in release of cytochrome c from mitochondria	IMP IMP: 通过突变表型推断	11301023	RGD
involved in response to cAMP	IEP IEP: 通过表达模式推断	18280640	RGD
involved in response to cytokine	IEP IEP: 通过表达模式推断	18280640	RGD
involved in response to ethanol	IEP IEP: 通过表达模式推断	22576626	RGD
involved in response to hydrogen peroxide	IEP IEP: 通过表达模式推断	11053775	RGD
involved in response to insulin	IEP IEP: 通过表达模式推断	20818503	RGD
involved in response to lipopolysaccharide	IEP IEP: 通过表达模式推断	11389931	RGD
involved in response to mechanical stimulus	IEP IEP: 通过表达模式推断	15126239	RGD
involved in response to organic cyclic compound	IEP IEP: 通过表达模式推断	11113530	RGD
involved in response to steroid hormone	IEP IEP: 通过表达模式推断	21948387	RGD
involved in response to xenobiotic stimulus	IEP IEP: 通过表达模式推断	12093589	RGD
involved in transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	10830307	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatin	IDA IDA: 通过直接分析推断	9300399	RGD
part of protein-containing complex	IDA IDA: 通过直接分析推断	19255142	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Jun 蛋白结构

Jun

bZIP_Jun

0
100
200
300
334 a.a.

蛋白主名

其他名称

transcription factor Jun

AP1	Avian sarcoma virus 17 (v-jun) oncogene homolog
Jun oncogene	V-jun avian sarcoma virus 17 oncogene homolog
activator protein 1	proto-oncogene c-jun
transcription factor AP-1	transcription factor AP-1 subunit Jun
v-jun sarcoma virus 17 oncogene homolog

Jun 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Jun	P17325	Mapk8	Rattus norvegicus	P49185	Pull Down	18046461
种属内	Jun	P17325	Fos	Rattus norvegicus	P12841	Anti Bait CoIP	32949970
种属内	Jun	P17325	Fos	Rattus norvegicus	P12841	Anti Bait CoIP	16876161

种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Approval

生物活性分子 (2)

目录号	产品名	作用方式	纯度	是否罕见病
HY-B1198	Piperonyl butoxide	Inhibitor	≥98.0%	否
HY-B1198R	Piperonyl butoxide (Standard)	Inhibitor	/	否

Clinical Phase

生物活性分子 (4)

目录号	产品名	作用方式	纯度	Phase
HY-12270	T-5224	Inhibitor	99.59%	Phase 2
HY-13241	Ralimetinib dimesylate		99.91%	Phase 2
HY-138304	CC-90001	Inhibitor	99.75%	Phase 2
HY-13241A	Ralimetinib	Inhibitor	/	Phase 2

Pre-clinical Phase

生物活性分子 (45)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-107598	JNK Inhibitor VIII	Inhibitor	99.46%	否
HY-W004283	Pentadecanoic acid		≥98.0%	否
HY-11010	AS601245	Inhibitor	98.83%	否
HY-148510	HKB99	Inhibitor	97.35%	否
HY-W010983	SC-236		99.56%	否
HY-125838	J30-8	Inhibitor	99.90%	否
HY-107599	AEG3482	Inhibitor	99.95%	否
HY-113438	15(S)-HPETE		97.3%	否
HY-107600	IQ-3	Inhibitor	99.38%	否
HY-P1190	c-JUN peptide		99.25%	否
HY-101287	MPT0B392		99.63%	否
HY-141582	Ceramide 3		≥98.0%	否
HY-157403	Jun12682		99.60%	否
HY-107621	U0124		≥98.0%	否
HY-114250	Cantrixil	Inducer	99.84%	是
HY-134975	NY2267	Inhibitor	98.53%	否
HY-P10506	CMX-8933	Activator	99.82%	否
HY-152142	DN-1289	Inhibitor	99.63%	否
HY-118529	JUN-1111	Inhibitor	98.57%	否
HY-B1198S	Piperonyl butoxide-d9	Inhibitor	/	否
HY-113443	12(S)-HPETE	Activator	/	否
HY-151928	JNK3 inhibitor-3	Inhibitor	/	否
HY-155593	JNK-1-IN-2	Inhibitor	/	否
HY-162922	MAP4K4-IN-6	Inhibitor	/	否
HY-168337	SET-171	Inhibitor	/	否
HY-168859	JNK3 inhibitor-9	Inhibitor	/	否
HY-169021	JNK-1-IN-3	Inhibitor	/	否
HY-169177	JNK-1-IN-4	Inhibitor	/	否
HY-169314	JNK-IN-19	Inhibitor	/	否
HY-P4699	(Thr17)-c-Jun (11-23)		/	否
HY-P6177	SGP8	Inhibitor	/	否
HY-RS07054	JUN Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS07055	Jun Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS07056	Jun Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-11010A	AS601245 TFA	Inhibitor	/	否
HY-121683	(E)-2-Hexadecenal		/	否
HY-138844	3-AP-Me	Activator	/	否
HY-141582S	Ceramide 3-d3		/	否
HY-157305	Jun11165	Inhibitor	/	否
HY-158751	Jun9-72-2	Inhibitor	/	否
HY-159985	Jun13728	Inhibitor	/	否
HY-171202	In vivo Jun Mouse Pre-designed siRNA-1	Pre-designed Sets	/	否
HY-171203	In vivo Jun Mouse Pre-designed siRNA-2	Pre-designed Sets	/	否
HY-171204	In vivo Jun Mouse Pre-designed siRNA-3	Pre-designed Sets	/	否
HY-P10401	TAT-GluR6-9c	Antagonist	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Jun	NCBI	NCBI:3725
Mus musculus	Jun	NCBI	NCBI:16476

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