Kdr - kinase insert domain protein receptor Gene

中文名称：激酶插入域蛋白受体

种属: Mus musculus

同用名: orv; Flk1; Ly73; Flk-1; Krd-1; VEGFR2; VEGFR-2; sVEGFR-2; 6130401C07

关于 Kdr

功能概要

该基因编码的蛋白可启动生长因子结合活性和血管内皮生长因子激活受体活性。参与多个过程，包括循环系统发育；肽基酪氨酸自磷酸化；和血管生成的正调节。作用于多个过程的上游或内部，包括动物器官发育；细胞群增殖的正向调节；和血管发育。位于多个细胞成分中，包括细胞连接；核内体；和质膜的外侧。以多种结构表达，包括消化系统；心血管系统;中枢神经系统;胚外成分；和泌尿生殖系统。该基因的人类直系同源物与多种疾病有关，包括子宫粘连；动脉疾病（多发性）；胃肠系统癌症（多发性）；黄斑变性（多发性）；和胰腺癌（多发）。与人类 KDR（激酶插入域受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including circulatory system development; peptidyl-tyrosine autophosphorylation; and positive regulation of vasculogenesis. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and vasculature development. Located in several cellular components, including cell junction; endosome; and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including adhesions of uterus; artery disease (multiple); gastrointestinal system Cancer (multiple); macular degeneration (multiple); and pancreatic Cancer (multiple). Orthologous to human VEGFR2/KDR/Flk-1 (kinase insert domain receptor). [provided by Alliance of Genome Resources, Apr 2022]