2. Gene
  3. DPEP1 - dipeptidase 1 Gene

DPEP1 - dipeptidase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：二肽酶 1

种属: Homo sapiens

同用名: MDP; RDP; MBD1

基因 ID: 1800 | 基因类型: protein coding

关于 DPEP1

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:89,613,308-89,641,540 (from NCBI)

This gene has 10 transcripts (splice variants), 200 orthologues and 2 paralogues. Biased expression in small intestine (RPKM 104.6), kidney (RPKM 102.2) and 3 other tissues.

功能概要

该基因编码的蛋白质是一种肾膜酶，通过二肽水解参与谷胱甘肽和其他类似蛋白质的代谢。已知编码的蛋白质通过催化白三烯 D4 转化为白三烯 E4 来调节白三烯活性。这种蛋白质使用锌作为辅助因子，并作为二硫键连接的同型二聚体。[RefSeq 提供，2020 年 12 月]

The protein encoded by this gene is a kidney membrane Enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. [provided by RefSeq, Dec 2020]

DPEP1 基因产物(8)

mRNA Protein Name
NM_001128141.3 NP_001121613.1 dipeptidase 1 isoform a precursor
NM_001389466.1 NP_001376395.1 dipeptidase 1 isoform a precursor
NM_001389467.1 NP_001376396.1 dipeptidase 1 isoform a precursor
NM_001389468.1 NP_001376397.1 dipeptidase 1 isoform a precursor
NM_001389469.1 NP_001376398.1 dipeptidase 1 isoform a precursor
NM_001389470.1 NP_001376399.1 dipeptidase 1 isoform b precursor
NM_001389471.1 NP_001376400.1 dipeptidase 1 isoform b precursor
NM_004413.4 NP_004404.1 dipeptidase 1 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-lactamase activity IDA
IDA: 通过直接分析推断
6334084 GOA
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
IMP: 通过突变表型推断
20435919 GOA
enables dipeptidase activity IDA
IDA: 通过直接分析推断
32325220 GOA
enables metallodipeptidase activity IDA
IDA: 通过直接分析推断
12144777 GOA
enables modified amino acid binding IDA
IDA: 通过直接分析推断
20031578 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
12144777 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antibiotic metabolic process IDA
IDA: 通过直接分析推断
6334084 GOA
involved in cellular response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
20435919 GOA
involved in homocysteine metabolic process IDA
IDA: 通过直接分析推断
20031578 GOA
involved in leukotriene D4 catabolic process IDA
IDA: 通过直接分析推断
32325220 GOA
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
20435919 GOA
involved in negative regulation of cell migration IMP
IMP: 通过突变表型推断
20824289 GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
20435919 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical part of cell IDA
IDA: 通过直接分析推断
20824289 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
12144777 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DPEP1 蛋白结构

Peptidase_M19

Peptidase_M19: Membrane dipeptidase (Peptidase family M19) (26 - 351)

  • 0
  • 100
  • 200
  • 300
  • 411 a.a.
蛋白主名 其他名称

dipeptidase 1

beta-lactamase

重组 DPEP1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70003 DPEP1 Protein, Human (HEK293, His) P16444 (D17-S385) ≥95%

关联疾病

疾病名称 别名
Blau Syndrome

Arthrocutaneouveal Granulomatosis

Jabs Syndrome

BLAUS

Sarcoidosis, Early-Onset

Acug

Granulomatous Inflammatory Arthritis, Dermatitis, And Uveitis, Familial

Eos

Granulomatosis, Familial Juvenile Systemic

Granulomatosis, Familial, Blau Type

Familial Juvenile Systemic Granulomatosis

Early Onset Sarcoidosis

Synovitis Granulomatous With Uveitis And Cranial Neuropathies

Early-Onset Sarcoidosis

Familial Granulomatosis, Blau Type

Pediatric Granulomatous Arthritis

Familial Granulomatosis Blau Type

Familial Granulomatous Inflammatory Arthritis Dermatitis And Uveitis

Synovitis, Granulomatous, With Uveitis And Cranial Neuropathies
Carbapenem Allergy
Bacterial Infectious Disease

Bacterial Infections

Bacterial Infection Nos

Disease Caused By Bacteria

Bacterial Disease Or Disorder
Crohn'S Disease

Crohn Disease

Pediatric Crohn'S Disease

Regional Enteritis

Crohn'S Disease Of Large Bowel

Granulomatous Colitis

Enteritis, Granulomatous

Enteritis

Crohn'S Disease Of Colon

Colitis, Granulomatous

Crohn'S Enteritis

Enteritis, Regional

Ileitis

Adenoviral Enteritis

Acute Gastroenteropathy Due To Norwalk Agent

Viral Gastroenteritis Due To Norwalk Agent

Winter Vomiting

Epidemic Winter Vomiting Disease

Small Round Structured Virus Enteritis

Epidemic Vomiting Syndrome

Epidemic Vomiting

Epidemic Nausea

Epidemic Viral Gastroenteritis Due To Norwalk Virus

Noroviral Enteritis

Crohn Disease Nos

Crohns

Cd - [Crohn'S Disease]

Regional Enteritis Of Bowel

Crohn'S Regional Enteritis

Cobble-Stone Appearance Of Intestine

Intestinal Ulcer And Erosion Due To Crohn Disease

Granulomatous Enteritis
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03947 DPEP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus DPEP1 VGNC VGNC:61593
Canis familiaris DPEP1 VGNC VGNC:49599
Macaca mulatta DPEP1 VGNC VGNC:71972
Mus musculus DPEP1 MGD MGI:94917
Bos taurus DPEP1 VGNC VGNC:49143
Rattus norvegicus DPEP1 RGD RGD:620324
Others DPEP1 NCBI
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