Pak1 - p21 (RAC1) activated kinase 1 Gene

中文名称：p21 (RAC1) 激活激酶 1

种属: Mus musculus

同用名: Paka; PAK-1

关于 Pak1

功能概要

该基因编码的蛋白可启动蛋白质丝氨酸/苏氨酸激酶活性。参与内源性大麻素的跨突触信号传导，调节突触传递。作用于多个过程的上游或内部，包括神经系统发育；神经递质分泌；和观察学习。位于多个细胞成分中，包括谷氨酸能突触；生长锥;和突触后密度。在 GABA 能突触中活跃。以多种结构表达，包括消化系统；中枢神经系统;泌尿生殖系统；呼吸系统;和感觉器官。该基因与乳腺癌相关的人类直向同源基因；肾细胞癌；和精神分裂症。与人 PAK1（p21 (RAC1) 激活激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein serine/threonine kinase activity. Involved in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Acts upstream of or within several processes, including nervous system development; neurotransmitter secretion; and observational learning. Located in several cellular components, including glutamatergic synapse; growth cone; and postsynaptic density. Is active in GABA-ergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]