2. Gene
  3. Pak1 - p21 (RAC1) activated kinase 1 Gene

Pak1 - p21 (RAC1) activated kinase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：p21 (RAC1) 激活激酶 1

种属: Mus musculus

同用名: Paka; PAK-1

基因 ID: 18479 | 基因类型: protein coding

关于 Pak1

Chromosome 7: 97,437,748-97,561,588 forward strand.GRCm39:CM001000.3

This gene has 6 transcripts (splice variants), 217 orthologues, 35 paralogues and is associated with 14 phenotypes. Biased expression in cortex adult (RPKM 87.8), cerebellum adult (RPKM 86.8) and 9 other tissues.

功能概要

该基因编码的蛋白可启动蛋白质丝氨酸/苏氨酸激酶活性。参与内源性大麻素的跨突触信号传导，调节突触传递。作用于多个过程的上游或内部，包括神经系统发育；神经递质分泌；和观察学习。位于多个细胞成分中，包括谷氨酸能突触；生长锥;和突触后密度。在 GABA 能突触中活跃。以多种结构表达，包括消化系统；中枢神经系统;泌尿生殖系统；呼吸系统;和感觉器官。该基因与乳腺癌相关的人类直向同源基因；肾细胞癌；和精神分裂症。与人 PAK1（p21 (RAC1) 激活激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein serine/threonine kinase activity. Involved in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Acts upstream of or within several processes, including nervous system development; neurotransmitter secretion; and observational learning. Located in several cellular components, including glutamatergic synapse; growth cone; and postsynaptic density. Is active in GABA-ergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pak1 基因产物(6)

mRNA Protein Name
NM_001403479.1 NP_001390408.1 serine/threonine-protein kinase PAK 1 isoform 2
NM_011035.3 NP_035165.2 serine/threonine-protein kinase PAK 1 isoform 1
NM_001357365.2 NP_001344294.1 serine/threonine-protein kinase PAK 1 isoform 1
NM_001357362.2 NP_001344291.1 serine/threonine-protein kinase PAK 1 isoform 2
NM_001357364.2 NP_001344293.1 serine/threonine-protein kinase PAK 1 isoform 1
NM_001357363.2 NP_001344292.1 serine/threonine-protein kinase PAK 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10967094 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
14580336 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
28408623 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within amygdala development IGI
IGI: 通过遗传相互作用推断
25242307 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: 通过直接分析推断
23509247 MGI
acts upstream of or within dendrite development IDA
IDA: 通过直接分析推断
12213441 MGI
acts upstream of or within dendritic spine development IGI
IGI: 通过遗传相互作用推断
23509247 MGI
acts upstream of or within gamma-aminobutyric acid secretion, neurotransmission IGI
IGI: 通过遗传相互作用推断
25242307 MGI
acts upstream of or within glutamate secretion, neurotransmission IGI
IGI: 通过遗传相互作用推断
25242307 MGI
acts upstream of or within neuromuscular junction development IGI
IGI: 通过遗传相互作用推断
12165471 MGI
acts upstream of or within observational learning IGI
IGI: 通过遗传相互作用推断
25242307 MGI
acts upstream of or within receptor clustering IGI
IGI: 通过遗传相互作用推断
12165471 MGI
acts upstream of or within regulation of MAPK cascade IGI
IGI: 通过遗传相互作用推断
25242307 MGI
acts upstream of or within regulation of gene expression IGI
IGI: 通过遗传相互作用推断
25242307 MGI
acts upstream of or within regulation of long-term synaptic potentiation IGI
IGI: 通过遗传相互作用推断
25242307 MGI
involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission EXP
EXP: 通过实验结果推断
27296803 MGI
involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IDA
IDA: 通过直接分析推断
27296803 MGI
involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IEP
IEP: 通过表达模式推断
27296803 MGI
involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IMP
IMP: 通过突变表型推断
27296803 MGI
acts upstream of or within transmission of nerve impulse IGI
IGI: 通过遗传相互作用推断
27583434 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse EXP
EXP: 通过实验结果推断
27296803 MGI
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
27296803 MGI
is active in GABA-ergic synapse IEP
IEP: 通过表达模式推断
27296803 MGI
is active in GABA-ergic synapse IMP
IMP: 通过突变表型推断
27296803 MGI
located in axon IDA
IDA: 通过直接分析推断
12950086 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
12213441 MGI
located in dendrite IDA
IDA: 通过直接分析推断
22022532 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
15182717 MGI
is active in glutamatergic synapse IEP
IEP: 通过表达模式推断
15182717 MGI
located in growth cone IDA
IDA: 通过直接分析推断
11604394 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12950086 MGI
is active in postsynaptic density IDA
IDA: 通过直接分析推断
15182717 MGI
located in postsynaptic density IDA
IDA: 通过直接分析推断
17114649 MGI
is active in postsynaptic density IEP
IEP: 通过表达模式推断
15182717 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pak1 蛋白结构

PBD

PBD: pfam00786 (73 - 131)

STKc_PAK1

STKc_PAK1: cd06654 (247 - 542)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 544 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase PAK 1

CDC42/RAC effector kinase PAK-A

P21 CDKN1A-activated kinase 1

activated protein kinase alpha

alpha-PAK

p21 protein (Cdc42/Rac)-activated kinase 1

p21-activated kinase 1

p65-PAK

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-12005 Fingolimod hydrochloride Activator 99.95% 是
HY-15027 5-Aminosalicylic Acid Inhibitor 99.82% 否
HY-11063 Fingolimod Activator 99.97% 是
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-13007 PF-3758309 Inhibitor 99.79% Phase 1
Pre-clinical Phase
生物活性分子 (19)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15663 IPA-3 Inhibitor 99.43% 否
HY-15542A FRAX597 Inhibitor 99.36% 否
HY-15542B FRAX486 Inhibitor 98.01% 否
HY-19635 G-5555 Inhibitor 99.88% 否
HY-120940 AZ13705339 Inhibitor 98.90% 否
HY-19538 FRAX1036 Inhibitor 99.49% 否
HY-19635A G-5555 hydrochloride Inhibitor 98.26% 否
HY-131043 NVS-PAK1-C Inhibitor 99.2% 否
HY-120940A AZ13705339 hemihydrate Inhibitor 99.77% 否
HY-13007A PF-3758309 hydrochloride Inhibitor / 否
HY-131265 Mesalamine impurity P Inhibitor / 否
HY-146681 PAK1-IN-1 Inhibitor / 否
HY-110085 2,2′-Dihydroxy-6,6′-dinaphthyl disulfide Inhibitor / 否
HY-146786 ZMF-10 Inhibitor / 否
HY-146783 ZINC194100678 Inhibitor / 否
HY-116917 G-9791 Inhibitor / 否
HY-13007B PF-3758309 dihydrochloride Inhibitor / 否
HY-159897 PAK4-IN-5 Inhibitor / 否
HY-164374 AK963/40708899 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pak1 NCBI NCBI:5058
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