EFNA5 - ephrin A5 Gene

中文名称：肾上腺素 A5

种属: Homo sapiens

同用名: AF1; EFL5; RAGS; EPLG7; GLC1M; LERK7

关于 EFNA5

功能概要

Ephrin-A5 是 ephrin 基因家族的一员，可防止皮质神经元与星形胶质细胞共培养时的轴突捆绑，星形胶质细胞是晚期神经系统发育和分化的模型。 EPH 和 EPH 相关受体包含受体蛋白-酪氨酸激酶的最大亚家族，并且与介导发育事件有关，特别是在神经系统中。 EPH 受体通常有一个激酶结构域和一个含有富含半胱氨酸结构域和 2 个纤连蛋白 III 型重复序列的胞外区。肝配蛋白配体和受体已由 Eph 命名委员会 (1997) 命名。基于它们的结构和序列关系，肝配蛋白分为肝配蛋白-A (EFNA) 类和肝配蛋白 B (EFNB) 类，前者通过糖基磷脂酰肌醇键固定在膜上，后者是跨膜蛋白。基于其细胞外结构域序列的相似性和它们对结合肝配蛋白-A 和肝配蛋白-B 配体的亲和力，Eph 受体家族同样分为 2 组。[RefSeq 提供，2008 年 7 月]

Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Eph Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]