2. Gene
  3. Tnks - tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase Gene

Tnks - tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：端锚聚合酶，TRF1 相互作用的锚蛋白相关的 ADP 核糖聚合酶

种属: Mus musculus

同用名: ARTD5; TANK1; mTNKS1; 4930554K12Rik; D130072O21Rik

基因 ID: 21951 | 基因类型: protein coding

关于 Tnks

Chromosome 8: 35,293,614-35,432,844 reverse strand.GRCm39:CM001001.3

This gene has 6 transcripts (splice variants), 279 orthologues, 2 paralogues and is associated with 58 phenotypes. Ubiquitous expression in testis adult (RPKM 23.3), whole brain E14.5 (RPKM 14.7) and 28 other tissues.

功能概要

预测该基因编码的蛋白可启动组蛋白结合活性；戊糖基转移酶活性；和锌离子结合活性。预计参与多个过程，包括维持有丝分裂姐妹染色单体内聚力、端粒的负调节；蛋白质 ADP-核糖基化；和调节含核碱基的化合物代谢过程。预计作用于肽基-丝氨酸磷酸化和肽基-苏氨酸磷酸化的上游或内部。位于胞质溶胶中。在中枢神经系统中表达；背根神经节；和神经视网膜。与人类 TNKS（端锚聚合酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Predicted to be involved in several processes, including negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric; protein ADP-ribosylation; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Located in cytosol. Is expressed in central nervous system; dorsal root ganglion; and neural retina. Orthologous to human TNKS (tankyrase). [provided by Alliance of Genome Resources, Apr 2022]

Tnks 基因产物(1)

mRNA Protein Name
NM_175091.3 NP_780300.2 poly [ADP-ribose] polymerase tankyrase-1
基因本体论
  • 细胞组分
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
23791195 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Tnks 蛋白结构

PTZ00322

PTZ00322: cl31426 (169 - 261)

ANK

ANK: sd00045 (210 - 238)

PHA02876

PHA02876: cl31517 (223 - 608)

ANK

ANK: sd00045 (240 - 271)

ANK

ANK: sd00045 (273 - 304)

ANK

ANK: sd00045 (363 - 391)

ANK

ANK: sd00045 (393 - 424)

ANK

ANK: sd00045 (426 - 457)

ANK

ANK: sd00045 (515 - 547)

ANK

ANK: sd00045 (549 - 580)

ANK

ANK: sd00045 (582 - 611)

PHA03095

PHA03095: cl33707 (644 - 968)

ANK

ANK: sd00045 (678 - 706)

ANK

ANK: sd00045 (708 - 739)

ANK

ANK: sd00045 (741 - 772)

ANK

ANK: sd00045 (828 - 859)

ANK

ANK: sd00045 (861 - 892)

ANK

ANK: sd00045 (894 - 925)

SAM_tankyrase1,2

SAM_tankyrase1,2: cd09524 (1016 - 1081)

tankyrase_like

tankyrase_like: cd01438 (1083 - 1305)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1320 a.a.
蛋白主名 其他名称

poly [ADP-ribose] polymerase tankyrase-1

ADP-ribosyltransferase diphtheria toxin-like 5

TRF1-interacting ankyrin-related ADP-ribose polymerase 1

protein poly-ADP-ribosyltransferase tankyrase-1

tankyrase I

tankyrase-1

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-108845 Tenecteplase Inhibitor ≥95.0% 否
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-12418 Stenoparib Inhibitor ≥98.0% Phase 2
HY-147245 Basroparib Inhibitor 98.49% Phase 1
Pre-clinical Phase
生物活性分子 (50)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15147 XAV-939 Inhibitor 99.91% 否
HY-13990 NVP-TNKS656 99.66% 否
HY-12438 G007-LK Inhibitor 99.24% 否
HY-14443 XMD8-92 Inhibitor 99.67% 否
HY-16910 WIKI4 Inhibitor 99.93% 否
HY-147316 TP-5801 Inhibitor 99.69% 否
HY-12975 AZ6102 Inhibitor 99.65% 否
HY-13968 JW 55 Inhibitor 98.95% 否
HY-15800A CZC-25146 Inhibitor 99.10% 否
HY-19351 MN-64 Inhibitor 99.61% 否
HY-145267 OM-153 Inhibitor 99.59% 否
HY-U00422 K-756 Inhibitor 99.25% 否
HY-148063 DB0614 98.80% 否
HY-123851 MSC2504877 Inhibitor 98.50% 否
HY-15811 XMD8-87 Inhibitor 98.15% 否
HY-101243 XMD16-5 Inhibitor 98.59% 否
HY-148061 DB1113 99.28% 否
HY-121719 TIQ-A Inhibitor 99.65% 否
HY-143338 ART-IN-1 Inhibitor 98.91% 否
HY-147316A TP-5801 TFA Inhibitor 99.34% 否
HY-126248 Tankyrase-IN-2 Inhibitor 99.06% 否
HY-147886 PARP1-IN-11 Inhibitor 98.58% 否
HY-156332 TNKS-2-IN-2 Inhibitor 99.47% 否
HY-148065 FMF-06-098-1 98.02% 否
HY-23338 TNKS-2-IN-1 Inhibitor 95.19% 否
HY-137849 RK-582 Inhibitor / 否
HY-100847 AZ0108 Inhibitor / 否
HY-108516 TC-E 5001 Inhibitor / 否
HY-117700 TNKS-IN-2 Inhibitor / 否
HY-12577 TNKS1/2-IN-1 Inhibitor / 否
HY-12601 TNKS 22 Inhibitor / 否
HY-145111 TNK2-IN-1 Inhibitor / 否
HY-146336 PARP1/2/TNKS1/2-IN-1 / 否
HY-152197 Tankyrase-IN-3 Inhibitor / 否
HY-152198 Tankyrase-IN-4 Inhibitor / 否
HY-153259 TNKS1/2-IN-2 Inhibitor / 否
HY-155246 PARP1-IN-15 / 否
HY-RS14837 TNK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14838 TNK2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14839 TNKS Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14840 Tnks Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14841 Tnks Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14842 TNKS1BP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14843 TNKS2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14844 Tnks2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14845 TNKS2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W294889 OUL245 Inhibitor / 否
HY-118731 TNK-6123 Activator / 否
HY-153332 Tankyrase-IN-5 Inhibitor / 否
HY-15800 CZC-25146 hydrochloride Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tnks NCBI NCBI:8658
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